Serum Levels of Beta1C Globulin, a Complement Component, in the Nephritides, Lipoid Nephrosis, and Other Conditions *

West, Clark D.; Northway, James D.; Davis, Neil C.

doi:10.1172/jci105027

Cited by 128 publications

(38 citation statements)

References 13 publications

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“…Although small amounts of C'3i or betalA globulin were detected in 2 of 14 normal plasma samples by antigen-antibody crossed electrophoresis, such material represented only 3 or 4% of the total C'3-related protein. Laurell and Lundh (31) have reported this phenomenon and found the presence of apparent conversion products in fresh serum or plasma an inconstant finding, even within the same sample examined on several different occasions.…”

Section: Resultsmentioning

confidence: 89%

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Studies of the In Vivo Behavior of Human C′3 in Normal Subjects and Patients*

Alper¹,

Rosen²

1967

J. Clin. Invest.

203

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Section: Resultsmentioning

confidence: 89%

“…It is known that C'3 concentration in serum is regularly low in patients with acute and progressive glomerulonephritis and is often low in patients with systemic lupus erythematosus (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Studies of the In Vivo Behavior of Human C′3 in Normal Subjects and Patients*

Alper¹,

Rosen²

1967

J. Clin. Invest.

203

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“…Group III constitutes only a relatively small proportion of children with the nephrotic syndrome. However, since the nephrotic syndrome can occur as a manifestation of acute poststreptococal glomerulonephritis (15), and since recent studies have established that immunologic mechanisms are operative in this disease (11,16,17), patients developing the nephrotic syndrome in the course of this disease could be included in this group.…”

Section: Discussionmentioning

confidence: 99%

The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

Drummond¹,

Michael²,

Good³

et al. 1966

J. Clin. Invest.

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“…In support of this are the granular deposits of IgG and Clq which can at times be demonstrated in the glomeruli with labeled antibody and the electron-dense subendothelial deposits demonstrable by electron microscopy (4 (26). Details of the use of this method for measurement of C3 were described previously (8,27). Results are expressed as the 11A globulin content of aged serum.…”

mentioning

confidence: 99%

Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis

Vallota¹,

Forristal²,

Spitzer³

et al. 1971

J. Clin. Invest.

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A B S T R A C T Serum levels of complement components and of C3 nephritic factor (C3NeF) were measured serially in two patients with membrano-proliferative glomerulonephritis who were subjected to bilateral nephrectomy and maintained by peritoneal dialysis for 2 wk before renal transplantation. In both patients, low levels of C3 and high levels of preformed alpha 2D, a C3 breakdown product, were present before nephrectomy and remained essentially unchanged during the anephric period. With transplantation, C3 levels rose towards normal and alpha 2D disappeared from the serum. The serum of both patients contained detectable amounts of C3NeF, a factor which has been shown to react with a cofactor found in normal serum to form an enzyme, designated C3 lytic nephritic factor (C3LyNeF), which will cleave C3 to form the breakdown products, plA and alpha 2D. The level of C3NeF was high in one patient before nephrectomy, increased somewhat during the anephric period, and fell after transplantation. In the other patient, the C3NeF level was initially lower, remained relatively constant during the anephric period, and was not significantly affected by transplantation. In both patients, levels of C4 and C5 were either normal or elevated over the period of the study and bore no relationship to the C3 level. The following conclusions can be drawn from the data. The high levels of alpha 2D during the anephric period and the disappearance of this protein as C3 levels approach normal at the time of transplantation indicate that the low C3 levels were largely the result of C3 breakdown rather than diminished synthesis. The presence of C3NeF in detectable amounts in both patients suggest that C3LyNeF, formed by the reaction of C3NeF and cofactor, was responsible for the low Dr. Vallota is a Fellow of the National Kidney Foundation.

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Serum Levels of Beta1C Globulin, a Complement Component, in the Nephritides, Lipoid Nephrosis, and Other Conditions *

Cited by 128 publications

References 13 publications

Studies of the In Vivo Behavior of Human C′3 in Normal Subjects and Patients*

Studies of the In Vivo Behavior of Human C′3 in Normal Subjects and Patients*

The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis

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