Arch Gen Psychiatry
 1980
DOI: 10.1001/archpsyc.1980.01780160063007
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Serum Levels of Anticholinergic Drugs in Treatment of Acute Extrapyramidal Side Effects

Larry E. Tune1
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Cited by 175 publications

(120 citation statements)
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“…41 Thus, several studies showed that an increased burden of SAA is associated with delirium. 13,42 In contrast, our own previous studies on SAA could not confirm the role of SAA as a biomarker for postoperative delirium 43 and long-term postoperative cognitive dysfunction. 7 This raised the question of whether there might be another marker characterizing cholinergic function.…”
Section: Discussioncontrasting
confidence: 81%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…41 Thus, several studies showed that an increased burden of SAA is associated with delirium. 13,42 In contrast, our own previous studies on SAA could not confirm the role of SAA as a biomarker for postoperative delirium 43 and long-term postoperative cognitive dysfunction. 7 This raised the question of whether there might be another marker characterizing cholinergic function.…”
Section: Discussioncontrasting
confidence: 81%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Since Asian patients have been reported to be more vulnerable to druginduced parkinsonism than Black or White patients [ 17], racial differences may be one of the factors that account for the differences found between our study and theirs. It has been reported that there is a significant inverse corre lation between serum concentrations of AP drugs and the presence of drug-induced extrapyramidal symptoms [18,19]. In the present study additional AP medication re sulted in improvement of RS and parkinsonian symp toms.…”
Section: Discussionsupporting
confidence: 63%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…11 In contrast, Tune and Coyle commented that SAA at 3.5 nmol and higher concentration was of benefit to schizophrenic patients in order to avoid extrapyramidal side-effects. 1 In the present study, the mean value of SAA was 4.14 nmol in SAA (+) AD patients. This was lower than the value that causes delirium in postoperative non-demented patients and somewhat higher than the value that causes clinical effects in schizophrenic patients reported by Tune and Coyle.…”
Section: Discussionsupporting
confidence: 47%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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