Serum Levels of Angiopoietin-Related Growth Factor (AGF) are Increased in Polycystic Ovary Syndrome

Boztosun, Abdullah; Deveci, Köksal; Kilicli, Fatih; Söylemez, Melike Sinem; Muhtaroğlu, Sabahaddin; Idot,; Idot, ptisam; Müderris, pek

doi:10.2310/jim.0b013e31824e9900

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…Recently, the serum ANGPTL6 levels of healthy individuals and patients with different metabolic diseases were assessed. Intriguingly, the serum ANGPTL6 levels were high in individuals who diagnosed with preeclampsia [15], polycystic ovary syndrome [16], and type 2 diabetes mellitus [1718]. Moreover, the serum ANGPTL6 levels of patients with metabolic syndrome was high [19].…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

et al. 2019

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Background Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome. Methods In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using an enzyme-linked immunosorbent assay. Anthropometric and biochemical markers were analyzed before and after follow-up examinations. Results During an average follow-up period of 2.75 (interquartile range, 0.76) years, 82 participants (37.1%) presented new-onset metabolic syndrome and had higher ANGPTL6 levels before onset than those without metabolic syndrome (48.03±18.84 ng/mL vs. 64.75±43.35 ng/mL, P =0.001). In the multivariable adjusted models, the odds ratio for the development of metabolic syndrome in the highest quartile of ANGPTL6 levels was 3.61 (95% confidence interval, 1.27 to 10.26). The use of ANGPTL6 levels in addition to the conventional components improved the prediction of new-onset metabolic syndrome (area under the receiver operating characteristic curve: 0.775 vs. 0.807, P =0.036). Conclusion Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

et al. 2019

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“…Kadomatsu et al suggested that ANGPTL6 resistance is likely to occur in obesity or diabetes 9 . ANGPTL6 levels were high in individuals who diagnosed with preeclampsia 10 , polycystic ovary syndrome 11 , and diabetes mellitus 6,8,13 .…”

Section: Discussionmentioning

confidence: 99%

Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis

ÖZTÜRK¹,

Ataseven²

2021

Cumhuriyet Medical Journal

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Obesity is an increasing health problem all over the world. Angiopoietinrelated growth factor (AGF, ANGPTL6) is a hepatocyte that directly regulates lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we investigated circulating AGF levels in relation to kidney function, type 2 diabetes mellitus and insulin resistance. Angiopoietin-related growth factor was determined by enzyme-linked immunosorbent assay in subjects with a normal glomerular filtration rate (n = 44, 22 diabetic and 22 nondiabetic) and in patients on chronic hemodialysis (CD; n = 44, 22 diabetic and 22 nondiabetic). Median serum AGF levels were 176,6± 96,6 μg/L inpatients who underwent dialysis and 186,0±81,7 μg/L in patients not on dialysis. There was no statistically significant difference between the mean serum AGF levels of the patients who underwent dialysis and those who did not(p>0.05). AGF serum levels were significantly increased in diabetic patients (222,56±90,61 μg/L) as compared with non-diabetic patients (140,12 ± 66,06 μg/L) (P <0.05). In addition, we evaluated the relationship between biochemical parameters and anthropometric measurements of the patients and AGF in our study. BMI, HOMA, waist/hip circumference ratios positively correlated with circulating AGF in all patients. Our results suggest that T2DM is positively associated with AGF serum levels. We think that this study will be useful to explain the pathogenesis of AGF in insulin resistance. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human. Keywords: Angiopoietin-related growth factor, diabetes mellitus, insulin resistance, chronic hemodialysis olmayan) . kronik hemodializ hastalarında ortalama serum AGF düzeyleri 176,6± 96,6 μg/L ve diyaliz almayan hastalarda 186,0±81,7 μg/L idi. Diyalize giren ve girmeyen hastaların ortalama serum AGF düzeyleri arasında istatistiksel olarak anlamlı fark yoktu (p>0.05). AGF serum seviyeleri diyabetik hastalarda (222,56±90,61 μg/L) diyabetik olmayan hastalarla (140,12 ± 66,06 μg/L) karşılaştırıldığında önemli ölçüde arttı (P <0.05). Ayrıca çalışmamızda hastaların biyokimyasal parametreleri ile antropometrik ölçümleri ile AGF arasındaki ilişkiyi değerlendirdik. BMI, HOMA, bel/kalça çevresi oranları tüm hastalarda dolaşımdaki AGF ile pozitif korelasyon gösterdi. Sonuçlarımız, T2DM'nin AGF serum seviyeleri ile pozitif ilişkili olduğunu göstermektedir. Bu çalışmanın insülin direncinde AGF'nin patogenezini açıklamak için faydalı olacağını düşünüyoruz. İnsanda dolaşan AGF'nin fizyolojik önemini daha iyi aydınlatmak için daha fazla çalışmaya ihtiyaç vardır. Anahtar sözcükler: Angiopoietin-related growth faktör, diabetes mellitus, insülin direnci, kronik hemodializ.

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“…132 In addition, exogenous AGF protein inhibits hepatic glucose production and decreased body weight. 133 Despite its beneficial effects on metabolism, serum levels of AGF were elevated in polycystic ovarian syndrome, 134 diabetes, 135 and metabolic syndrome, 136 similar to FGF21 or GDF15. Kim et al 137 observed that high fat diet increased hepatic AGF expression, that was reduced by exercise training.…”

Section: Agf (Angptl6)mentioning

confidence: 99%

Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

Chang

Kong

et al. 2022

Gut and Liver

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Nonalcoholic fatty liver disease (NAFLD) is accompanied by a complex and multifactorial pathogenesis with sequential progressions from inflammation to fibrosis and then to cancer. This heterogeneity interferes with the development of precise diagnostic and prognostic strategies for NAFLD. The current approach for the diagnosis of simple steatosis, steatohepatitis, and cirrhosis mainly consists of ultrasonography, magnetic resonance imaging, elastography, and various serological analyses. However, individual dry and wet biomarkers have limitations demanding an integrative approach for the assessment of disease progression. Here, we review diagnostic strategies for simple steatosis, steatohepatitis and hepatic fibrosis, followed by potential biomarkers associated with fat accumulation and mitochondrial stress. For mitochondrial stress indicators, we focused on fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), angiopoietin-related growth factor and mitochondrial-derived peptides. Each biomarker may not strongly indicate the severity of steatosis or steatohepatitis. Instead, multidimensional analysis of different groups of biomarkers based on pathogenic mechanisms may provide decisive diagnostic/prognostic information to develop a therapeutic plan for patients with NAFLD. For this purpose, mitochondrial stress indicators, such as FGF21 or GDF15, could be an important component in the multiplexed and contextual interpretation of NAFLD. Further validation of the integrative evaluation of mitochondrial stress indicators combined with other biomarkers is needed in the diagnosis/prognosis of NAFLD.

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Serum Levels of Angiopoietin-Related Growth Factor (AGF) are Increased in Polycystic Ovary Syndrome

Abstract: Serum AGF levels were paradoxically increased in patients with PCOS in comparison with data of animal experiments. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human disease.

Cited by 9 publications

References 26 publications

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis

Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

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