Serum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes.

Berg, Tore Julsrud; Snorgaard, Ole; Faber, Jens; Torjesen, Peter A.; Hildebrandt, Per; Mehlsen, Jesper; Hanssen, Kristian F.

doi:10.2337/diacare.22.7.1186

Cited by 177 publications

(132 citation statements)

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“…16 Several investigators have speculated that the mechanism of such 'diabetic cardiomyopathy' might be collagen accumulation, which causes a decrease in myocardial compliance, calcium handling abnormality or a cardiac autonomic neuropathy. [17][18][19] …”

Section: Diabetesmentioning

confidence: 99%

Analysis of Chronic Heart Failure Registry in the Tohoku District-Third Year Follow-up-

Shiba

Watanabe

Shinozaki

et al. 2004

Circ J

101

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Section: Diabetesmentioning

confidence: 99%

Analysis of Chronic Heart Failure Registry in the Tohoku District-Third Year Follow-up-

Shiba

Watanabe

Shinozaki

et al. 2004

Circ J

101

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“…2,[4][5][6] However, previous studies on the association between circulating AGEs and LV structure and function showed mixed results. For example, some studies, [7][8][9] but not all, 10 showed that higher circulating AGEs were associated with impaired diastolic function. Such mixed results were also seen for systolic function.…”

Section: Introductionmentioning

confidence: 99%

Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study

Linssen

Henry

Schalkwijk³

et al. 2016

Diabetes and Vascular Disease Research

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Objective: To investigate whether serum advanced glycation endproducts are associated with left ventricular systolic and diastolic function in participants with normal glucose metabolism, impaired glucose metabolism and type 2 diabetes mellitus. Methods: Participants from a cross-sectional, population-based study (n = 280 with normal glucose metabolism, n = 171 with impaired glucose metabolism, n = 242 with type 2 diabetes mellitus) underwent echocardiography. Serum proteinbound advanced glycation endproducts [i.e. Nε-(carboxymethyl)lysine, pentosidine and Nε-(carboxyethyl)lysine] were measured. Linear regression analyses were used and stratified according to glucose metabolism status. Results: In normal glucose metabolism, higher Nε-(carboxymethyl)lysine and pentosidine levels were associated with worse diastolic function (left atrial volume index and left atrial volume × left ventricular mass index product term) and higher Nε-(carboxymethyl)lysine and Nε-(carboxyethyl)lysine levels with worse systolic function (ejection fraction). In impaired glucose metabolism, a similar pattern emerged, though less consistent. In type 2 diabetes mellitus, these associations were non-existent for diastolic function or even reversed for systolic function. Conclusion: This suggests that serum advanced glycation endproducts are associated with impaired left ventricular function in normal glucose metabolism, but that with deteriorating glucose metabolism status, serum advanced glycation endproducts may not mirror heart failure risk.

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“…31,32 Experimental studies suggest that increased advanced glycation end-product formation associated with hyperglycaemia may be linked with increased myocardial stiffening and dysfunction. 33,34 Increased myocardial fibrosis presumably contributes to myocardial ischaemia due to the reduction in capillary density and coronary reserve. 32 Recently, even subclinical renal damage has been associated with impaired coronary flow reserve.…”

Section: Discussionmentioning

confidence: 99%

Impact of type 2 diabetes on left ventricular geometry and diastolic function in hypertensive patients with chronic kidney disease

et al. 2010

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Left ventricular hypertrophy (LVH) and diastolic dysfunction are very common in patients with chronic kidney disease (CKD). Aim of this study was to evaluate the impact of type 2 diabetes on LV geometry and diastolic function in hypertensive patients with CKD. We enrolled 288 Caucasian subjects with hypertension and CKD; of them, 112 had diabetes. Patients with cardiovascular (CV) diseases, glomerular filtration rate (GFR) 460 ml min À1 per 1.73 m 2 , dialysis treatment and other major non-CV diseases were excluded. All patients underwent routine biochemical analyses and echocardiographic examination with tissue Doppler imaging (TDI). Patients with diabetes had significantly higher LV wall thicknesses (P ¼ 0.0001), relative wall thickness (RWT) (P ¼ 0.0001) and left atrium volume index (P ¼ 0.03), when compared with patients without diabetes. Further, diabetic patients had very high prevalence of concentric LVH. Em, evaluated by TDI, was significantly lower in patients with diabetes (P ¼ 0.005). However, the difference lost statistical significance after correction by analysis of covariance for RWT. Multiple stepwise linear regression analysis showed that the variables independently associated with Em were: age (b 0.364; P ¼ 0.0001), GFR (beta 0.101; P ¼ 0.019), and the presence of diabetes (b 0.166; P ¼ 0.002). Our study showed that in hypertensive patients with CKD the presence of diabetes is associated with increased LV-wall thicknesses and concentric geometry; further, diabetes together with renal function (GFR) is associated with worse diastolic function, independently of potential confounders, such as age, gender, body mass index and blood pressure.

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Serum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes.

Abstract: Increased serum levels of AGEs, unlike serum levels of CML, are associated with heart stiffness in patients with type 1 diabetes, possibly mediated by the cross-linking properties of AGEs.

Cited by 177 publications

References 0 publications

Analysis of Chronic Heart Failure Registry in the Tohoku District-Third Year Follow-up-

Analysis of Chronic Heart Failure Registry in the Tohoku District-Third Year Follow-up-

Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study

Impact of type 2 diabetes on left ventricular geometry and diastolic function in hypertensive patients with chronic kidney disease

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