Serum levels of 25-hydroxy vitamin D in psoriatic patients

Abstract

Studies have shown a relationship between vitamin D and psoriasis. We compared serum levels of vitamin D of 20 psoriasis patients and 20 controls. The median vitamin D level was 22.80 ± 4.60 ng/ml; the median in the cases was 23.55 ± 7.6 ng/ml, and in controls 22.35 ± 3.10 ng/ml (p = 0.73). Only 2 cases and 4 controls had sufficient levels of vitamin D, although without statistical significance between the groups (p = 0.608). Levels were lower in women with psoriasis compared with those in male patients (20.85 ± 6.70 x 25.35 ± 2.90 ng/ml, p = 0.03), a finding that was not observed among controls.

Pilot study: immunohistochemistry expressions of vitamin D receptor associated with severity of disease in psoriasis patients

“…From a total of 28 specimens in our study, the proportion of females (60.7%) was higher than males (39.3%). Only one study was consistent with our study, namely the study by Zuchi et al that reported a higher proportion of female psoriasis (60%) than male psoriasis (40%) 20 . Otherwise, the proportion of male psoriasis was higher than female, varying from 52% to 66% 10,17,21,22 .…”

Association between Vitamin D Deficiency and Psoriasis: A Case-Control Study

“…Notably, Ryan et al [21] showed that, in patients with psoriasis, mean serum levels of 25(OH) D increased from 23 to 42 ng/ml after 12 sessions of NB-UVB, increasing further to 51 ng/ml by the end of treatment; these changes were accompanied by decreases in PASI and Dermatologic Life Quality Index scores. The results of the present study showed a mean vitamin D level for the psoriasis patients of 16 ± 10 ng/ml (range 3-53 ng/ml), which was not significantly different from the level of the control group of 16 ± 9 ng/ml (range 4-58 ng/ml); this provided further support for the findings of Wilson et al [12], Zuchi et al [24], and Maleki et al [25]. However, Ricceri et al [26] found a prevalence of 68% of vitamin D deficiency and 97% of insufficiency in patients with psoriasis, compared with 10% deficiency and 53% insufficiency in their control group.…”

Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis

“…4 However, studies that have compared circulating 25 (OH)D levels between patients with psoriasis and healthy controls (HCs) and determined the relationship between 25(OH)D levels and psoriasis severity have reported inconsistent results. [5][6][7][8][9][10][11][12][13][14][15][16] To overcome the limitations of individual studies and resolve inconsistencies, we performed a metaanalysis, comparing the serum/plasma 25(OH)D levels between patients with psoriasis and HCs, and evaluated the correlation of these levels with disease severity.…”