Serum level of interleukin‐35 as a potential prognostic factor for gastric cancer

Gu, Jin-Hua; Wang, Xiaoge; Wang, Liqiang; Zhou, Lina; Tang, Min; Li, Ping; Wu, Xiaoyang; Chen, Min-Bin; Zhang, Yan

doi:10.1111/ajco.13403

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Fan et al 128 revealed IL-35 is involved in the proliferation of gastric cancer cells by upregulating the expression of Ki67 and reducing apoptosis. Similarly, Gu et al 129 observed that the enhanced serum level of IL-35 correlates with disease prognosis in gastric cancer patients. Furthermore, Chen et al demonstrated the elevated level of IL-35 in serum and tumor tissues of breast cancer patients is associated with tumor progression.…”

Section: Immune-suppressive Cytokines Il-10 Tgf-β Il-4 and Il-35 In Cancer And Immunotherapymentioning

confidence: 84%

Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy

Mirlekar

2022

SAGE Open Medicine

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Cytokines play a critical role in regulating host immune response toward cancer and determining the overall fate of tumorigenesis. The tumor microenvironment is dominated mainly by immune-suppressive cytokines that control effector antitumor immunity and promote survival and the proliferation of cancer cells, which ultimately leads to enhanced tumor growth. In addition to tumor cells, the heterogeneous immune cells present within the tumor milieu are the significant source of immune-suppressive cytokines. These cytokines are classified into a broad range; however, in most tumor types, the interleukin-10, transforming growth factor-β, interleukin-4, and interleukin-35 are consistently reported as immune-suppressive cytokines that help tumor growth and metastasis. The most emerging concern in cancer treatment is hijacking and restraining the activity of antitumor immune cells in the tumor niche due to a highly immune-suppressive environment. This review summarizes the role and precise functions of interleukin-10, transforming growth factor-β, interleukin-4, and interleukin-35 in modulating tumor immune contexture and its implication in developing effective immune-therapeutic approaches. Concise conclusion Recent effort geared toward developing novel immune-therapeutic approaches faces significant challenges due to sustained mutations in tumor cells and a highly immune-suppressive microenvironment present within the tumor milieu. The cytokines play a crucial role in developing an immune-suppressive environment that ultimately dictates the fate of tumorigenesis. This review critically covers the novel aspects of predominant immune-suppressive cytokines such as interleukin-10, transforming growth factor-β, interleukin-4, and interleukin-35 in dictating the fate of tumorigenesis and how targeting these cytokines can help the development of better immune-therapeutic drug regimens for the treatment of cancer.

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Section: Immune-suppressive Cytokines Il-10 Tgf-β Il-4 and Il-35 In Cancer And Immunotherapymentioning

confidence: 84%

Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy

Mirlekar

2022

SAGE Open Medicine

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“…Moreover, in patients with arterial hypertension, alterations in IL-12, IL-23, IL-27, IL-35, and IL-37 concentrations are connected with the development of carotid atherosclerotic plaque [157,158]. All aforementioned cytokines are also associated with H. pylori infection [159][160][161][162].…”

Section: H Pylori-related Mets Parameters and Arterial Hypertensionmentioning

confidence: 99%

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

et al. 2021

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Arterial hypertension is a risk factor for several pathologies, mainly including cardio-cerebrovascular diseases, which rank as leading causes of morbidity and mortality worldwide. Arterial hypertension also constitutes a fundamental component of the metabolic syndrome. Helicobacter pylori infection is one of the most common types of chronic infection globally and displays a plethora of both gastric and extragastric effects. Among other entities, Helicobacter pylori has been implicated in the pathogenesis of the metabolic syndrome. Within this review, we illustrate the current state-of-the-art evidence, which may link several components of the Helicobacter pylori-related metabolic syndrome, including non-alcoholic fatty liver disease and arterial hypertension. In particular, current knowledge of how Helicobacter pylori exerts its virulence through dietary, inflammatory and metabolic pathways will be discussed. Although there is still no causative link between these entities, the emerging evidence from both basic and clinical research supports the proposal that several components of the Helicobacter pylori infection-related metabolic syndrome present an important risk factor in the development of arterial hypertension. The triad of Helicobacter pylori infection, the metabolic syndrome, and hypertension represents a crucial worldwide health problem on a pandemic scale with high morbidity and mortality, like COVID-19, thereby requiring awareness and appropriate management on a global scale.

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“…The assessment of the levels of interleukins in the human body can be used as a diagnostic indicator of the development or progression of many diseases (cancers [ 16 , 17 , 18 , 19 ], heart disease [ 20 , 21 , 22 ] and neurological disorders [ 23 , 24 , 25 ]) affecting contemporary society, including kidney diseases [ 26 , 27 , 28 , 29 , 30 ]. That is why it is extremely important to conduct further extensive scientific and clinical research to assess the biological functions of interleukins and their interactions with other cells of the body, which may lead to health deterioration.…”

Section: Introductionmentioning

confidence: 99%

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

Mertowska

Mertowski

Smarz-Widelska³

et al. 2022

IJMS

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Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic susceptibility, infections, immune disorders or high blood pressure is suggested. Difficulties in making a correct and quick diagnosis are caused by the lack of research on early molecular markers, as well as educational and preventive activities among the public, which leads to the late detection of kidney diseases. An important role in the homeostasis and disease progression, including kidney diseases, is attributed to interleukins, which perform several biological functions and interact with other cells and tissues of the body. The aim of this article was to systematize the knowledge about the biological functions performed by interleukins in humans and their involvement in kidney diseases development. In our work, we took into account the role of interleukins in acute and chronic kidney disease and kidney transplantation.

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Serum level of interleukin‐35 as a potential prognostic factor for gastric cancer

Cited by 8 publications

References 32 publications

Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy

Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

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