Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5

Lu, Jing-Wun; Chi, Po-Jui; Lin, Yu‐Li; Wang, Chih‐Hsien; Hsu, Bang‐Gee

doi:10.1080/21623945.2020.1764799

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…In CKD patients, leptin levels were found to correlate positively with the circulating soluble forms of ICAM-1 and VCAM-1 [ 104 ]. In patients with stage 3–5 CKD, leptin levels also correlated positively with aortic stiffness [ 106 ], known to be connected to arterial media calcification [ 107 ].…”

Section: Leptinmentioning

confidence: 99%

New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

et al. 2022

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Chronic kidney disease (CKD) is commonly associated with a high burden of comorbidities and poor clinical outcomes. Malnutrition–inflammation–atherosclerosis syndrome is common in the more severe stages of CKD, suggesting a close interplay for these three comorbid conditions. Both malnutrition and obesity are associated with a disturbed adipokine profile and inflammation, contributing to a higher risk of cardiovascular disease (CVD) events. Adiponectin and leptin have important roles in carbohydrate and lipid metabolism, and in the inflammatory process. The effects of adiponectin and leptin alterations in CKD, which are usually increased, and their association with the different comorbidities found in CKD, will be focused on to understand their crosstalk with the risk of CVD events. Nonetheless, although adiponectin and leptin contribute to a higher risk of CVD events, further studies are warranted to fully clarify their roles, especially when different comorbidities exist.

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Section: Leptinmentioning

confidence: 99%

New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

et al. 2022

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“…Positive correlations between leptin and increased carotid–femoral PWV have also been reported in patients with hypertension [ 88 ], coronary artery disease [ 89 ], chronic kidney disease patients in predialytic stages [ 90 ] and also in hemodialysis patients [ 91 ]. In patients with type 2 diabetes mellitus, leptin independently correlated with brachial–ankle PWV [ 92 ].…”

Section: Proinflammatory Cytokines and Arterial Stiffnessmentioning

confidence: 96%

Adipokines and Arterial Stiffness in Obesity

2021

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Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent predictor of cardiovascular morbidity and mortality. The pathogenesis of arterial stiffness is complex but incompletely understood. Adipokines dysregulation may induce, by various mechanisms, vascular inflammation, endothelial dysfunction, and vascular remodeling, leading to increased arterial stiffness. This article summarizes literature data regarding adipokine-related pathogenetic mechanisms involved in the development of arterial stiffness, particularly in obesity, as well as the results of clinical and epidemiological studies which investigated the relationship between adipokines and arterial stiffness.

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“…The study was conducted among 205 patients with CKD stage 3–5 without dialysis and kidney transplantation (KT). Other risk factors of aortic stiffness were higher systolic blood pressure (SBP) and older age [ 79 ]. Similar research results were obtained in HD patients and those after KT.…”

Section: Adipokines and Their Influence On Pathogenesis Nutritional D...mentioning

confidence: 99%

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

et al. 2022

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Obesity is a disease which leads to the development of many other disorders. Excessive accumulation of lipids in adipose tissue (AT) leads to metabolic changes, including hypertrophy of adipocytes, macrophage migration, changes in the composition of immune cells, and impaired secretion of adipokines. Adipokines are cytokines produced by AT and greatly influence human health. Obesity and the pro-inflammatory profile of adipokines lead to the development of chronic kidney disease (CKD) through different mechanisms. In obesity and adipokine profile, there are gender differences that characterize the male gender as more susceptible to metabolic disorders accompanying obesity, including impaired renal function. The relationship between impaired adipokine secretion and renal disease is two-sided. In the developed CKD, the concentration of adipokines in the serum is additionally disturbed due to their insufficient excretion by the excretory system caused by renal pathology. Increased levels of adipokines affect the nutritional status and cardiovascular risk (CVR) of patients with CKD. This article aims to systematize the current knowledge on the influence of obesity, AT, and adipokine secretion disorders on the pathogenesis of CKD and their influence on nutritional status and CVR in patients with CKD.

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Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5

Cited by 10 publications

References 35 publications

New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

New Insights into Adiponectin and Leptin Roles in Chronic Kidney Disease

Adipokines and Arterial Stiffness in Obesity

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

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