Serum LDH, a prognostic factor in elderly patients with acute myelogenous leukaemia

Dalley, Christopher; Lister, T. Andrew; Cavenagh, Jamie; Rohatiner, A. Z. S.

doi:10.1054/bjoc.2000.1537

Cited by 9 publications

(4 citation statements)

References 4 publications

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“…Besides age, elevated LDH levels ( P = 0.041) and low platelet count at diagnosis ( P = 0.016) proved to be independent predictors of shorter OS, as in other studies .…”

Section: Discussionmentioning

confidence: 91%

Complex karyotype, older age, and reduced first‐line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long‐term follow‐up

et al. 2015

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Approximately 40% of patients affected by core binding factor (CBF) acute myeloid leukemia (AML) ultimately die from the disease. Few prognostic markers have been identified. We reviewed 192 patients with CBF AML, treated with curative intent (age, 15-79 years) in 11 Italian institutions. Overall, 10-year overall survival (OS), disease-free survival (DFS), and event-free survival were 63.9%, 54.8%, and 49.9%, respectively; patients with the t(8;21) and inv(16) chromosomal rearrangements exhibited significant differences at diagnosis. Despite similar high complete remission (CR) rate, patients with inv(16) experienced superior DFS and a high chance of achieving a second CR, often leading to prolonged OS also after relapse. We found that a complex karyotype (i.e., 4 cytogenetic anomalies) affected survival, even if only in univariate analysis; the KIT D816 mutation predicted worse prognosis, but only in patients with the t(8;21) rearrangement, whereas FLT3 mutations had no prognostic impact. We then observed increasingly better survival with more intense first-line therapy, in some high-risk patients including autologous or allogeneic hematopoietic stem cell transplantation. In multivariate analysis, age, severe thrombocytopenia, elevated lactate dehydrogenase levels, and failure to achieve CR after induction independently predicted longer OS, whereas complex karyotype predicted shorter OS only in univariate analysis. The achievement of minimal residual disease negativity predicted better OS and DFS. Long-term survival was observed also in a minority of elderly patients who received intensive consolidation. All considered, we identified among CBF AML patients a subgroup with poorer prognosis who might benefit from more intense first-line treatment.

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“…Besides age, elevated LDH levels ( P = 0.041) and low platelet count at diagnosis ( P = 0.016) proved to be independent predictors of shorter OS, as in other studies .…”

Section: Discussionmentioning

confidence: 91%

Complex karyotype, older age, and reduced first‐line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long‐term follow‐up

et al. 2015

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“…A high-peripheral WBC count together with a raised serum LDH, the presence of hepatosplenomegaly, and EML, may reflect an increased tumor burden in AML even in the setting of "good risk" acute leukemias, such as acute promyelocytic leukemia or CBF-AML [19,[38][39][40]. In AML with inv(16), Delaunay et al [20] reported that bad prognosis factors for CR achievement were a high WBC count, with an optimal cut-off point at 120 3 10 9 /L, and lower platelet count.…”

Section: Discussionmentioning

confidence: 99%

Old and new prognostic factors in acute myeloid leukemia with deranged core‐binding factor beta

et al. 2013

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Acute myeloid leukemia (AML) with deranged core‐binding factor beta (CBFβ) is usually associated with a favorable prognosis with 50–70% of patients cured using contemporary treatments. We analyzed the prognostic significance of clinical features on 58 patients with CBFβ‐AML aged ≤60 years. Increasing age was the only predictor for survival (P <0.001), with an optimal cut‐point at 43 years. White blood cells (WBCs) at diagnosis emerged as an independent risk factor for relapse incidence (P = 0.017), with 1.1% increase of hazard for each 1.0 × 109/L WBC increment. KIT mutations lacked prognostic value for survival and showed only a trend for relapse incidence (P = 0.069). Am. J. Hematol. 88:594–600, 2013. © 2013 Wiley Periodicals, Inc.

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“…ID was associated with elevated LDH . Factors significantly affecting OS were cytogenetic risk group, AML type, WCC and LDH …”

Section: Discussionmentioning

confidence: 91%

Intensive chemotherapy and reduced‐intensity allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in elderly patients

Jackson

Kennedy

Mollee

et al. 2014

Asia-Pac J Clncl Oncology

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Serum LDH, a prognostic factor in elderly patients with acute myelogenous leukaemia

Cited by 9 publications

References 4 publications

Complex karyotype, older age, and reduced first‐line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long‐term follow‐up

Complex karyotype, older age, and reduced first‐line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long‐term follow‐up

Old and new prognostic factors in acute myeloid leukemia with deranged core‐binding factor beta

Intensive chemotherapy and reduced‐intensity allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia in elderly patients

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