Serum Interleukin ‐ 2 Receptor Levels and Cutaneous T‐cell Lymphoma

Gilmore, Stephen; Benson, Elizabeth M.; Kelly, John W.

doi:10.1111/j.1440-0960.1991.tb00074.x

Cited by 4 publications

(7 citation statements)

References 11 publications

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“…Serum sIL2R concentrations were determined using an enzyme‐linked immunosorbent assay (ELISA) test kit (T‐Cell Science Inc., Cambridge, MA) 5 . Values for CD4 positive and CD8 positive cells were obtained by laser flow cytometry (Ortho, NJ) using OKT4A and OKT8 monoclonal antibodies (Ortho, NJ).…”

Section: Methodsmentioning

confidence: 99%

Clinical significance of the soluble interleukin‐2 receptor as a putative systemic nutritional index in the elderly*

Kikuchi

Inagaki²,

Shinagawa³

et al. 2004

Geriatrics Gerontology Int

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Background:The clinical significance of a slight increase in serum soluble interleukin-2 receptor (sIL2R) concentration in the stable elderly was investigated. Methods:The subjects consisted of 35 residents of nursing homes with physical impairment as a sequela to cerebral infarctions, who had no inflammatory conditions, and were not receiving anodyne or immunological treatment. They were divided into two groups: 24 subjects without overt or suspected malignancy (NC) and 11 with a history of malignancy (CA). Serological screening with measurement of sIL2R concentrations was performed and numbers of lymphocytes with CD4 and CD8 markers were determined. The NC group was subdivided into control subjects ( n = 15, sIL2R < = 883 U/mL) and subjects demonstrating elevated concentrations of sIL2R ( n = 9, NH), as in a previous study. Results:Between the NH and control groups, differences were found in serum concentrations of albumin, blood urea nitrogen, total cholesterol concentration, Pettigrew's prognostic nutritional index (PNI) and activities of daily living score, but not in age or sex. Factor analysis in the NC group showed serum creatinine and blood urea nitrogen concentrations to be correlated positively, and serum albumin, total cholesterol concentrations, activities of daily living score, and PNI to be correlated negatively with sIL2R. Differences were found in sIL2R, albumin, total protein, total cholesterol, b -lipoprotein and PNI between the CA and control groups, but no correlations among these parameters were found in the CA group. There was no difference in the rate of positive test results for rheumatoid factor between the NC and CA, or control and NH groups. The survival rate of control subjects over 24 months was better than that of NH subjects, but not that of CA subjects. Conclusion:Our results suggest that a slight increase in the concentration of sIL2R is related to subclinical systemic deterioration, especially regarding nutrition, with a plausible connection to prognosis, in stable elderly patients without malignancy.

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Section: Methodsmentioning

confidence: 99%

Clinical significance of the soluble interleukin‐2 receptor as a putative systemic nutritional index in the elderly*

Kikuchi

Inagaki²,

Shinagawa³

et al. 2004

Geriatrics Gerontology Int

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“…5 For 15 subjects in the NC group sIL2R levels were within the normal range and they were assigned to a control group. 5 For 15 subjects in the NC group sIL2R levels were within the normal range and they were assigned to a control group.…”

Section: Discussionmentioning

confidence: 99%

“…The normal range of sIL2R was found to be between 61 U/mL and 883 U/mL which was determined to be within the permissible range of 95%, as mentioned in a previous study using the same method. 5 For 15 subjects in the NC group sIL2R levels were within the normal range and they were assigned to a control group. The remaining nine subjects had sIL2R levels of greater than 884 U/mL and were assigned to a group designated as NH.…”

Section: Discussionmentioning

confidence: 99%

“…5 Values for CD4 positive and CD8 positive cells were obtained by laser flow cytometry (Ortho, NJ) using OKT4A and OKT8 monoclonal antibodies (Ortho, NJ). 5 Values for CD4 positive and CD8 positive cells were obtained by laser flow cytometry (Ortho, NJ) using OKT4A and OKT8 monoclonal antibodies (Ortho, NJ).…”

Section: Measurement Of Serum Sil2r Concentrationsmentioning

confidence: 99%

“…Serum sIL2R concentrations were determined using an enzyme-linked immunosorbent assay (ELISA) test kit (T-Cell Science Inc., Cambridge, MA). 5 Values for CD4 positive and CD8 positive cells were obtained by laser flow cytometry (Ortho, NJ) using OKT4A and OKT8 monoclonal antibodies (Ortho, NJ). Total numbers of leukocytes in the peripheral blood were counted with an E-4000 automated blood cell analyzer (Sysmex, Kobe, Japan) and then the numbers of lymphocytes were determined.…”

Section: Measurement Of Serum Sil2r Concentrationsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Significance of Soluble Interleukin-2 Receptor as a Putative Systemic Nutritional Index in the Elderly.

Kikuchi

Inagaki²,

Shinagawa³

et al. 2002

Jpn. j. geriat

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Biological significance of soluble IL‐2 receptor

Caruso

Candore

Cigna

et al. 1993

Mediators of Inflammation

123

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A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC) activation and interleukin-2 receptor (IL-2R) expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R) is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. The blood sIL-2R levels depend on the number of producing cells and the number of molecules per cell, so that sIL-2R blood values may represent an index of the number and the functional state of producing cells, both normal and neoplastic. Thus, monitoring of the immune system, mostly T-cells and haematological malignancies might be targets for the measurement of sIL-2R. Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. The precise biological role of the soluble form of the IL-2R is still a matter of debate. However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. It is conceivable then that in these conditions the excess sIL-2R released in vivo by activated lymphoid cells or by neoplastic cells may somehow regulate IL-2-dependent processes. On the other hand, it cannot exclude that sIL-2R is a by-product without biological significance. Finally, it is puzzling that in many conditions in which an increase of blood sIL-2R values has been observed, MNCs display a decreased in vitro capacity to produce sIL-2R. These seemingly contrasting findings are discussed in the light of the data showing that sIL-2R production correlates with IL-2 production.

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Serum Interleukin ‐ 2 Receptor Levels and Cutaneous T‐cell Lymphoma

Cited by 4 publications

References 11 publications

Clinical significance of the soluble interleukin‐2 receptor as a putative systemic nutritional index in the elderly*

Clinical significance of the soluble interleukin‐2 receptor as a putative systemic nutritional index in the elderly*

Clinical Significance of Soluble Interleukin-2 Receptor as a Putative Systemic Nutritional Index in the Elderly.

Biological significance of soluble IL‐2 receptor

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