Serum immuno-biomarkers in gliomas

Buerki, Robin; Lukas, Rimas V.

doi:10.20517/2347-8659.2016.41

Cited by 1 publication

(15 citation statements)

References 19 publications

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“…Using a cutoff value of NLR<4.7, both overall survival (OS) and progression-free survival (PFS) were significantly longer. This study supports another work [2,16] which also revealed NLR as an independent prognostic marker, using a cut-off value of 4, and is consistent with other studies demonstrating the prognostic value of NLR in other tumor types [2,17,18].…”

Section: Need For Diagnostic Biomarkers For Gliomasupporting

confidence: 92%

“…This is why invasive glioma has a low cure rate and a high recurrence rate. In this direction, a promising new tool to combat GBM is immunotherapy, which has emerged from intensive research, revealing that although highly immunogenic, it actively suppresses the host anti-tumoral immune response through a number of mechanisms [2,12,13]. A deeper understanding of specific molecular markers is the core part of such immunotherapy.…”

Section: Need For Diagnostic Biomarkers For Gliomamentioning

confidence: 99%

“…Recent work by Alexiou et al contributes to the use of immune mediators as prognostic surrogates of GBM aggressiveness & survival and may be clinical indicators, of which patients are likely to benefit in current and future immunotherapeutic trials [2,14,15]. In a study, Alexiou et al [2,10,14] demonstrated a lower neutrophil-to-lymphocyte ratio (NLR) as an independent prognostic marker of survival. Using a cutoff value of NLR<4.7, both overall survival (OS) and progression-free survival (PFS) were significantly longer.…”

Section: Need For Diagnostic Biomarkers For Gliomamentioning

confidence: 99%

“…Extensive work has explored the role of tumorinfiltrating lymphocytes (TILs) in glioma, both as markers of tumor aggressiveness and with patient survival, showing that infiltration of cytotoxic CD8+ T lymphocytes are decreased and CD4+ and CD4+/CD25+/FoxP3+ (Treg) populations of T lymphocytes increased in higher grade tumors, with increased Treg infiltration indicating a worse prognosis [2,19]. Han et al [2,20] established that NLR reflects the presence of TILs within the tumor milieu.…”

Section: Need For Diagnostic Biomarkers For Gliomamentioning

confidence: 99%

“…Brain tumors are widespread with an incidence of 12.8 per 100,000 population. Glioma, a devastating condition, originating from glial cells of brain or spine, is the most common subgroup of primary malignant brain tumors in adults, constituting >40% of all primary CNS neoplasms [1][2][3][4]. Although all gliomas originate from neuroepithelial tissues, they vary considerably in morphology, location, genetic alterations and in their response to therapy.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Review on Immunological Biomarkers in Gliomas

Nagalakshmi¹,

Santhosh²

2019

Madridge J Immunol

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Gliomas are the most common subgroup of primary malignant brain tumors in adults, constituting >40% of all primary CNS neoplasms. Although all gliomas originate from neuroepithelial tissues, they vary considerably in morphology, location, genetic alterations and in their response to therapy. The most malignant of gliomas (Grade IV) is Glioblastoma Multiforme (GBM), causing over 10,000 deaths each year in the US alone. Despite robust therapeutic advances, median survival for GBM still remains 14-20 months with very high tumor recurrence rate. Various investigation modalities are available for establishing diagnosis of glioma, like: CT scan, MRI, X-ray, spinal tap, angiogram, myelogram & biopsy, though, histopathology represents the gold standard for their typing & grading. However, even this remains unsatisfactory because of the lack of reproducibility and absence of precision. Development of objective, diagnostic, prognostic & predictive markers for these lethal neoplasms is therefore a priority. Biomarkers for glioma can be identified in various biological samples like: DNA, mRNA, cell surface receptors, transcription factors, secretory proteins, metabolites or processes such as proliferation, angiogenesis or apoptosis. Tumor biomarkers help oncologists in managing gliomas at various levels, from screening till assessment of longitudinal response to therapy. Identifying the molecular & pathogenetic characteristics of glioma regulation network may increase the precision of customized medication. Further, the proteomic approach has the potential to identify novel diagnostic, prognostic and therapeutic biomarkers. In the near future, improved proteomic profiling is anticipated to bring about a merger of biology, engineering and informatics, with a profound impact on glioma research and treatment. Optimization of experimental design and validation in independent cohorts, improved multiplex proteomic methodologies and bioinformatics tools, and their integration with genetic and metabolomic profiling technologies promise to play critical roles in the post proteomics era of cancer diagnosis and treatment.

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