Serum Immune Mediators Independently Associate with Atherosclerosis in the Left (But Not Right) Carotid Territory of Older Individuals

Machado-Silva, Wilcelly; Henriques, Adriane Dallanora; Souza, Gleim Dias de; Gomes, Lucy; Ferreira, Aparecido Pimentel; Brito, Ciro José; Córdova, Cláudio; Moraes, Clayton Franco; Nóbrega, Otávio Tolêdo

doi:10.1016/j.jstrokecerebrovasdis.2016.07.047

Cited by 10 publications

(9 citation statements)

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“…The exact mechanisms between ACOS and neurodegenerative diseases are not clear, however it may partially be explained by coexistence of the systemic inflammation in both ACOS [ 32 ] and neurodegenertative diseases [ 33 ]. Several studies have reported an association between an increased atherosclerosis-related [ 34 ] inflammation markers [(e.g. TNF-α [ 33 ] and an increased risk of neurodegenerative diseases [ 32 ], including stroke [ 34 ], dementia and PD [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported an association between an increased atherosclerosis-related [ 34 ] inflammation markers [(e.g. TNF-α [ 33 ] and an increased risk of neurodegenerative diseases [ 32 ], including stroke [ 34 ], dementia and PD [ 35 ]. The level of TNF-α increased in the ACOS cohort [ 36 ] and its value is higher than the control groups [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, as previous mention [ 39 – 41 ], the oxidative stress of the chronic obstructive airway disease associated neurodegenerative diseases [ 39 ]. Similarly, the severe form of the ACOS with high frequency of AE and the hospitalization [ 16 ]; thus, the intermittent hypoxemia [ 42 ] and oxidative stress aggravate the exists the atherosclerosis [ 34 ] of system artery (e.g. carotid artery).…”

Section: Discussionmentioning

confidence: 99%

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Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

et al. 2017

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BackgroundTo evaluate the association of asthma–chronic obstructive pulmonary disease syndrome (ACOS) with neurodegenerative diseases (stroke, Parkinson's disease and dementia) and the role of the steroids in the neurodegenerative diseases among the ACOS cohort.Materials and MethodsComparison of the ACOS cohort (N = 10,260) with the non-ACOS cohort (n = 20,513) based on the patients aged ≧40 years in the National Health Insurance Research Database from January 1, 2000 to December 31, 2010. These patients follow up to diagnosis of neurodegenerative diseases or the December 31, 2011; using multivariable Cox proportional hazards models.ResultsAfter adjustment for potential confounders, the [adjusted hazard ratio (aHR), 95% confidence interval (CI)] in the ACOS cohort were [1.39, 1.28–1.50] [1.56, 1.34–1.81] and [1.43, 1.29–1.59] for stroke, Parkinson's disease, dementia; respectively. The [aHR, 95% CI] for ACOS cohort with (inhaler corticosteroids ≧0.13 gram/ oral steroids ≧0.08gram) were with less risk (all aHR<1, p values <0.05) for these 3 neurodegenerative diseases except Parkinson's disease with inhaler corticosteroids >0.43 gram. The risk of stroke and dementia were the lower in patients with < 250 μg/d of a fluticasone equivalent inhaler corticosteroids (aHR = 0.53, 95% CI = 0.35–0.79; aHR = 0.53, 95% CI = 0.31–0.90, respectively).ConclusionsThe ACOS cohort had a higher risk of the neurodegenerative diseases. The lower dose of the inhaler corticosteroids with cumulative dose ≧0.13 gram have the less risk of stroke and dementia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

et al. 2017

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“…Collagen deposition, arterial stiffening (Fleenor et al, 2010) Tumour necrosis factor-TNF-Endothelial, smooth muscle, circulation Human, rat, mouse Associated with CVD, impaired EDD; role in large artery stiffening (Belmin et al, 1995;Csiszar et al, 2003;Donato et al, 2008;Machado-Silva et al, 2016;Moreau et al, 2013) CC motif chemokine ligand 2; otherwise known as monocyte chemoattractant protein 1 CCL2 Endothelial, smooth muscle, perivascular adipose…”

Section: Tgf-whole Artery Mousementioning

confidence: 99%

“…Polymorphisms that promote production of IL-6 and IFN-and decrease production of IL-10 are associated with development of carotid plaques in older adults (Annoni et al, 2009;Giacconi et al, 2004). In octogenarians, high levels of TNF-, CRP, IL-1 and IL-6 and low levels of IL-10 are associated with increased coronary artery calcification and carotid artery intima-media thickness (Freitas et al, 2011;Machado-Silva et al, 2016;Quaglia et al, 2014). It should be noted that IFN-and IL-17a, pro-inflammatory cytokines for which there is evidence of participation in age-related arterial dysfunction, were not associated with carotid artery disease in older adults (Machado-Silva et al, 2016).…”

Section: Correlational Evidence Of Inflammation and Cvdmentioning

confidence: 99%

Inflammation as a mediator of arterial ageing

Trott

Fadel

2019

Experimental Physiology

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New Findings What is the topic of this review?This review summarizes and synthesizes what is known about the contribution of inflammation to age‐related arterial dysfunction. What advances does it highlight?This review details observational evidence for the relationship of age‐related inflammation and arterial dysfunction, insight from autoimmune inflammatory diseases and their effects on arterial function, interventional evidence linking inflammation and age‐related arterial dysfunction, insight into age‐related arterial inflammation from preclinical models and interventions to ameliorate age‐related inflammation and arterial dysfunction. Abstract Advanced age is a primary risk factor for cardiovascular disease, the leading cause of death in the industrialized world. Two major components of arterial ageing are stiffening of the large arteries and impaired endothelium‐dependent dilatation in multiple vascular beds. These two alterations are major contributors to the development of overt cardiovascular disease. Increasing inflammation with advanced age is likely to play a role in this arterial dysfunction. The purpose of this review is to synthesize what is known about inflammation and its relationship to age‐related arterial dysfunction. This review discusses both the initial observational evidence for the relationship of age‐related inflammation and arterial dysfunction and the evidence that inflammatory autoimmune diseases are associated with a premature arterial ageing phenotype. We next discuss interventional and mechanistic evidence linking inflammation and age‐related arterial dysfunction in older adults. We also attempt to summarize the relevant evidence from preclinical models. Lastly, we discuss interventions in both humans and animals that have been shown to ameliorate age‐related arterial inflammation and dysfunction. The available evidence provides a strong basis for the role of inflammation in both large artery stiffening and impairment of endothelium‐dependent dilatation; however, the specific inflammatory mediators, the initiating factors and the relative importance of the endothelium, smooth muscle cells, perivascular adipose tissue and immune cells in arterial inflammation are not well understood. With the expansion of the ageing population, ameliorating age‐related arterial inflammation represents an important potential strategy for preserving vascular health in the elderly.

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Best Practice Recommendations for Stroke Patients with Dysphagia: A Delphi-Based Consensus Study of Experts in Turkey-Part I: Management, Diagnosis, and Follow-up

et al. 2021

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Serum Immune Mediators Independently Associate with Atherosclerosis in the Left (But Not Right) Carotid Territory of Older Individuals

Cited by 10 publications

References 47 publications

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

Inflammation as a mediator of arterial ageing

Best Practice Recommendations for Stroke Patients with Dysphagia: A Delphi-Based Consensus Study of Experts in Turkey-Part I: Management, Diagnosis, and Follow-up

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