Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer

Abstract

Background: Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods: We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwestern China. Univariate and multivariate Cox proportional-hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results: Controlled for possible confounding factors, serum GGT was significantly associated with OS: serum GGT >48 U/L yielded a hazard ratio of 1.53 (95%CI: 1.19-1.97) for mortality risk. A significant dose-response association between serum GGT and OS was also observed. Subgroup analysis showed a possible interaction between GGT and blood glucose level. Conclusion: Serum GGT could be a potential indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.

Diagnostic value of gamma‐glutamyl transpeptidase to alkaline phosphatase ratio combined with gamma‐glutamyl transpeptidase to aspartate aminotransferase ratio and alanine aminotransferase to aspartate aminotransferase ratio in alpha‐fetoprotein‐negative hepatocellular carcinoma

“…In other studies, the relationship between hematologic parameters (GAR and GAPR) and clinical characteristics (Child-Pugh grades and tumor size) have been demonstrated. 22,23 Study has also demonstrated that the GAPR was significant associated with BCLC stage, vascular invasion, and tumor size of HCC. 12 GAR was a superior prognostic factor for survival outcome than several potential prognostic indices.…”

“…20 Xu et al suggested that preoperative serum GGT ≥115 U/L and ALP >120 U/L in HCC patients were more invasive, and their overall survival was significantly shortened. 21 In many cancers, the increase of serum GGT is negatively correlated with survival, [22][23][24] and this inverse correlation is most obvious in HCC. 25 However, ALP is secreted in normal tissues such as the bone, liver, and small intestine and is increased when metabolic disorders, inflammation, and tumors develop.…”

Aberrant lactate dehydrogenase A signaling contributes metabolic signatures in pancreatic cancer

“…At the beginning of glycolysis, the glucose in the serum of our cancer participants was remarkably upregulated. Serum glucose concentration was positively associated with PC (34), and there were reports that high blood glucose levels of PC patients were also associated with poorer outcomes and increased mortality hazard (35,36). The ROC results using these glycolysis-related metabolites indicated that these serum metabolites could be good identifiers of PC; the combinative metabolites score was calculated using lactic acid, pyruvic acid, citric acid, and glucose, and was shown to be significantly higher in healthy cohorts, which may indicate potential as biomarkers for monitoring the curative effects of LDHA inhibitors.…”

Molecular Landscape for Malignant Transformation in Diffuse Astrocytoma

“…23 GGT1 transcribes gamma-glutamyltransferase 1 that is associated with a favorable prognosis in renal and ovarian cancers, while these were significantly associated with mortality in the metastatic pancreatic ductal adenocarcinoma. 24,25 However, those need further exploration, the association with MT in DA, from more samples because there was the limitation of a small sample size. The process of MT occurred in the range of 7 to 68 months, and the routine collection of tumor specimens in the tumor bank will increase the number of specimens for further confirmatory study in the future.…”