1996
DOI: 10.1001/archderm.132.10.1201
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Serum from normal elderly individuals contains anti-basement membrane zone antibodies

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Cited by 17 publications
(24 citation statements)
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“…57 Results for IIF have generally shown o5% positivity 55,56 although this was 19% (n = 32) in another study. 58 Autoreactive T cells recognising the basement membrane protein BP 180, are also present in healthy individuals expressing the HLA-DQB*0301 gene (although not in those who did not). 59 These autoreactive T cells are thought to be prevented from developing a pathological response by the activity of both regulatory T cells (Treg) 60 and regulatory B cells (Breg).…”
Section: Pathogenesismentioning
confidence: 99%
“…57 Results for IIF have generally shown o5% positivity 55,56 although this was 19% (n = 32) in another study. 58 Autoreactive T cells recognising the basement membrane protein BP 180, are also present in healthy individuals expressing the HLA-DQB*0301 gene (although not in those who did not). 59 These autoreactive T cells are thought to be prevented from developing a pathological response by the activity of both regulatory T cells (Treg) 60 and regulatory B cells (Breg).…”
Section: Pathogenesismentioning
confidence: 99%
“…The antibodies were found to be present at low titers using indirect immunofluorescence (IF) and not present with direct IF in six of 32 elderly patients. 41 The IF findings are in contrast to nonbullous pemphigoid, where the direct IF is positive. The existence in many elderly patients of low titers of antibasement membrane antibodies could provide another theory for the pathogenesis of Willan's itch.…”
Section: Figure 2 Connections and Pathways Between The Causes And Manmentioning
confidence: 95%
“…In these individuals, tissue-bound IgG could not be detected at the epidermal basement membrane by direct immunofluorescence microscopy of perilesional skin biopsies. [89][90][91] Although some studies show a higher incidence of BP autoantibodies in the elderly, there are also conflicting reports that describe an equal distribution among the young and older populations. [89][90][91] Nevertheless, there is increasing evidence that the incidence of anti-BP230 and/or anti-BP180specific IgG autoantibodies is much higher in elderly individuals with pruritic dermatoses, which suggests a possible relationship between pruritus and antibasement membrane autoantibodies.…”
Section: Immunological Alterations In Bullous Pemphigoidmentioning
confidence: 99%
“…[89][90][91] Although some studies show a higher incidence of BP autoantibodies in the elderly, there are also conflicting reports that describe an equal distribution among the young and older populations. [89][90][91] Nevertheless, there is increasing evidence that the incidence of anti-BP230 and/or anti-BP180specific IgG autoantibodies is much higher in elderly individuals with pruritic dermatoses, which suggests a possible relationship between pruritus and antibasement membrane autoantibodies. [92][93][94][95][96] By indirect immunofluorescence microscopy of patients' sera on saline-split skin or monkey oesophagus, these IgG autoantibodies show a staining pattern identical to BP sera.…”
Section: Immunological Alterations In Bullous Pemphigoidmentioning
confidence: 99%