2013
DOI: 10.18632/aging.100584
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Abstract: Calorie restriction (CR) without malnutrition is the most robust intervention to slow aging and extend healthy lifespan in experimental model organisms. Several metabolic and molecular adaptations have been hypothesized to play a role in mediating the anti-aging effects of CR, including enhanced stress resistance, reduced oxidative stress and several neuroendocrine modifications. However, little is known about the independent effect of circulating factors in modulating key molecular pathways. In this study, we… Show more

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Cited by 18 publications
(17 citation statements)
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References 24 publications
(37 reference statements)
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“…We found that 48 h of culture with AN serum was sufficient to induce the expression of GPX3 and to downregulate NOX5, an enzyme that generates superoxide. These data are consistent with data obtained in individuals on longterm calorie restriction that have also increased levels of serum adiponectin [33,34].…”
Section: Discussionsupporting
confidence: 92%
“…We found that 48 h of culture with AN serum was sufficient to induce the expression of GPX3 and to downregulate NOX5, an enzyme that generates superoxide. These data are consistent with data obtained in individuals on longterm calorie restriction that have also increased levels of serum adiponectin [33,34].…”
Section: Discussionsupporting
confidence: 92%
“…On the other hand, clinical validations reported no adverse effects of CAE on the health status of subjects. These findings are in agreement with previous studies reporting that moderate restriction in calorie and CHO intake would have a potent beneficial effect on obesity, inflammation, hypertension, cardiovascular problems, and diabetes mellitus, could slow aging, reduce cancer incidence, delay disease onset, and extend life span, whereas most of the uncontrolled dietary restriction regimens might induce malnutrition and health problems, especially if taken for a long-term period (Cava and Fontana, 2013;Omodei et al, 2013).…”
Section: Discussionsupporting
confidence: 93%
“…More recent studies have also linked circulating components in the blood with cellular rejuvenation [16,40,41]. In keeping with these findings, ex vivo use of serum from calorie-restricted mammals reproduces many CR effects in cell cultures [14,17,28,42], demonstrating that these effects are linked to serum components, rather than the chronology of the cells themselves.…”
Section: Discussionmentioning
confidence: 65%