Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy

Doğan, Erkan; Sevinç, Eylem

doi:10.14238/pi59.3.2019.119-24

Cited by 7 publications

(11 citation statements)

References 25 publications

(22 reference statements)

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“…Vitamin D deficiency during childhood is known to cause growth retardation and nutritional rickets (2). Recently, an increasing number of studies have indicated that low levels of vitamin D may play an important role in the occurrence and development of extraskeletal diseases because of its immunoregulation and anti-inflammatory effects (3,4), such as allergic diseases (5), respiratory illnesses (6), and obesity in children (7). Although there is no consensus on the association between vitamin D and related health outcomes, most specialists believe that sufficient vitamin D is essential and protective for children's health.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou

Chen

Xi²,

Hu³

et al. 2021

Front. Public Health

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Objective: Vitamin D deficiency and insufficiency in children are global public health problems. However, few studies have focused on vitamin D status in healthy preschool children, especially in Asia. This study aimed to investigate vitamin D status and host-related factors in healthy preschool children in Hangzhou to analyze the impact of low vitamin D levels (<30 ng/mL) on health outcomes (obesity, early childhood caries, and respiratory tract infections).Methods: A total of 1,510 healthy children aged 24–72 months from 15 kindergartens in Hangzhou were included. Data on the children's gender, age, body mass index (BMI), caries, and blood samples available for vitamin D analysis were collected from June to August 2018. A total of 325 children aged 36–48 months took part in a survey on the frequency of respiratory tract infections in the last year.Results: The children's mean 25(OH)D level was 28.01 ± 7.29 ng/mL. A total of 11.4% of the children had vitamin D deficiency, and 52.6% had vitamin D insufficiency. Only 36.0% had vitamin D sufficiency. No significant difference was found by gender or BMI group. However, children in the obesity group had the highest prevalence of vitamin D deficiency and the lowest 25(OH)D levels. A significant negative correlation was found between the 25(OH)D level and child age (r = −0.144, p < 0.001). Regression analysis showed that the children’s 25(OH)D levels decreased by 0.17 ng/mL per month with age. In addition, children with low vitamin D levels might increase the risk of obesity and early childhood caries. Multiple linear regression indicated that the number of caries in children increased by 0.08 per 1-ng/mL decrease in the 25(OH)D level (β = −0.08, p < 0.001).Conclusion: Vitamin D deficiency/insufficiency is a serious problem among healthy preschool children in Hangzhou. Public health policies or interventions should be implemented to ensure that preschool children have adequate vitamin D to reduce the risk of related diseases.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou

Chen

Xi²,

Hu³

et al. 2021

Front. Public Health

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“…We found that the eosinophil count (495/mm 3 ) of the infants with a milk protein allergy was significantly lower at the first follow-up visit than before dietary intervention (655/mm 3 ) and that the number of eosinophils at the second follow-up visit (330/mm 3 ) was significantly lower than that at the first follow-up visit (495/mm 3 ). In a similar study by Dogan et al [ 43 ] found significantly higher eosinophil cationic protein levels (51.45 ng/mL) and blood eosinophil counts (475/mm 3 ) in infants with a milk protein allergy than in controls (17.55 ng/mL, 300/mm 3 ). Recently, Li et al [ 44 ] found that in 6-month-old infants with a milk protein allergy, eosinophil counts were higher than those of the nonallergic group (0.89 ± 0.45/mm 3 and 0.26 ± 0.12/mm 3 , respectively, p < 0.01).…”

Section: Discussionmentioning

confidence: 75%

“…All of the above studies have found that infants with a milk protein allergy have an increased number of eosinophils in their blood. The eosinophils formed in the bone marrow have large cytoplasmic granules, which contain eosinophil cationic protein, eosinophil protein X, and eosinophil-derived neurotoxin [ 43 ]. The eosinophil cationic protein encoded by the RNASE3 gene is a cytotoxic protein that enters the surrounding tissues when activated eosinophils degranulate and manifests as an increase in the level of eosinophils in the surrounding tissues [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophilic cationic protein is one of the four main basic proteins in specific granules in the cytoplasm of eosinophils. It can reflect the activity of eosinophils and elevated levels in body fluids such as saliva, serum and feces in the course of inflammatory processes and allergic diseases [ 43 ]. When inflammation and allergic reactions occur in the body, the level of fecal calprotectin and the number of eosinophils is increased [ 10 , 43 , 46 ], so the level of fecal calprotectin and the number of eosinophils is positively correlated.…”

Section: Discussionmentioning

confidence: 99%

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Can fecal calprotectin levels be used to monitor infant milk protein allergies?

Qiu

Wang

Ren

et al. 2021

Allergy Asthma Clin Immunol

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Background Milk protein allergy is one of the most common food allergies in infants. We aimed to test whether fecal calprotectin can be used to monitor food allergies in infants by comparing the fecal calprotectin levels in infants with a milk protein allergy before and after an intervention treatment. Methods The study was designed as a prospective case–control trial. Stool samples were collected at follow-up, and the concentration of fecal calprotectin was determined using an enzyme-linked immunosorbent assay. The infant’s weight and length were measured. Results The allergic group comprised 90 milk-allergic infants (41 boys, 49 girls), and the nonallergic group comprised 90 nonallergic infants (51 boys, 39 girls). Compared with the fecal calprotectin level in the nonallergic group (median: 141 μg/g), that in the allergic group (median: 410 μg/g) was significantly higher (z = − 9.335, p < 0.001). After two dietary interventions and treatments, the fecal calprotectin levels of the infants with a milk protein allergy at the first (median: 253 μg/g) and second follow-up visits (median: 160 μg/g) were significantly lower than those before the intervention (z = − 7.884, p < 0.001 and z = − 8.239, p < 0.001, respectively). The growth index values (LAZ and WAZ) of the infants with a milk protein allergy at the first and second follow-up visits were significantly higher than those before dietary intervention (p < 0.05). Fecal calprotectin was negatively and significantly correlated with the WLZ and WAZ at the second follow-up visit (Spearman’s rho = − 0.234, p = 0.01 and Spearman’s rho = − 0.193, p = 0.03, respectively). Conclusion The level of fecal calprotectin in infants with a milk protein allergy decreased after dietary intervention and seems to be a promising biological indicator for monitoring intestinal allergies.

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“…Investigation is needed into the characteristics and interactions among biochemical indicators of bone metabolism in children with CMPA to improve evaluation of bone metabolism status in children, reduce the incidence of metabolic bone disease, and more accurately monitor the effect of treatment. Many studies have shown that vitamin D is closely related to the occurrence and development of allergic diseases 7 ; however, the conclusions of these studies have not been consistent. Few studies have focused on the biochemical markers of bone metabolism in children with CMPA.…”

Section: Introductionmentioning

confidence: 93%

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

Che

Guo

et al. 2022

J Int Med Res

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Objective Research is limited regarding biochemical markers of bone metabolism among children with cow’s milk protein allergy (CMPA). We aimed to determine differences in vitamin D and bone metabolism markers between infants with CMPA and healthy infants and explore relationships between these in a cross-sectional study. Methods In total, we included 41 children diagnosed with CMPA and under systematic medical and nutritional care at our center, and 50 healthy children as a control group. We reviewed demographic and clinical characteristics and measured serum biomarkers. Results We found that serum 25-hydroxyvitamin D (25(OH)D) levels among infants in the CMPA group were significantly lower than those in the control group, and levels of bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin were reduced. Pearson correlation analysis showed that serum 25(OH)D concentrations in the CMPA group were negatively correlated with parathyroid hormone but not significantly correlated with calcitonin and BALP. Logistic regression showed that CMPA was a risk factor for vitamin D deficiency. Conclusions Our study indicated that CMPA was associated with disturbances in bone metabolism. Levels of vitamin D in children with CMPA were lower than those in healthy children. CMPA was a risk factor for vitamin D deficiency.

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Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy

Cited by 7 publications

References 25 publications

Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou

Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou

Can fecal calprotectin levels be used to monitor infant milk protein allergies?

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

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