Serum DHEA-S increases in dogs naturally infected with Ehrlichia canis

Rondelli, Mariana Cristina Hoeppner; Munhoz, Thiago Demarchi; Catandi, Pâmela B.; Freschi, Carla Roberta; Palacios, Reinaldo Juan Garrido; Machado, Rosangela Zacarias; Tinucci‐Costa, Mirela

doi:10.1016/j.rvsc.2015.04.010

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Circulating DHEAS is higher in both male and female dogs infected with Ehrlichia canis compared with healthy counterparts (114). Conversely, plasma concentrations of DHEA are lower in cats infected by feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV), and animals infected by both retroviruses had significantly lower DHEA plasma values than monoinfected cats (115).…”

Section: Immuno-stressors In Domestic Animals "In Vivo"mentioning

confidence: 99%

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

et al. 2020

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In animal husbandry, stress is often associated with poor health and welfare. Stress occurs when a physiological control system detects a state of real or presumptive threat to the animal's homeostasis or a failure to control a fitness-critical variable. The definition of stress has mostly relied on glucocorticoids measurement, even though glucocorticoids represent one stress-response system, the hypothalamus-pituitary-adrenocortical axis, which is not precise enough as it is also related to metabolic regulation and activated in non-stressful situations (pleasure, excitement, and arousal). The mammal adrenal can synthesize the androgenic steroid dehydroepiandrosterone (DHEA) and its sulfate metabolite (DHEAS), which have been associated to the stress response in several studies performed mostly in humans and laboratory animals. Although the functions of these steroids are not fully understood, available data suggest their antagonistic effects on glucocorticoids and, in humans, their secretion is affected by stress. This review explores the scientific literature on DHEA and DHEAS release in domestic animals in response to stressors of different nature (inflammatory, physical, or social) and duration, and the extra-adrenal contribution to circulating DHEA. Then, the potential use of DHEA in conjunction with cortisol to improve the definition of the stress phenotype in farmed animals is discussed. Although the focus of this review is on farmed animals, examples from other species are reported when available.

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Section: Immuno-stressors In Domestic Animals "In Vivo"mentioning

confidence: 99%

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

et al. 2020

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“…*DHEA measured, not DHEAS. Circulating DHEAS shown for canine ( Schiebinger et al 1981 , Odell & Parker 1985 , Tremblay & Belanger 1985 , Ashley et al 1988 , Mialot et al 1988 , Frank et al 2003 , Mongillo et al 2014 , Rondelli et al 2015 ); boar ( Schuler et al . 2014 ); Anthropoid primates ( Cutler et al 1978 , Axelson et al 1984 , Sulcova et al 1997 , Kemnitz et al 2000 , Bjornerem et al 2006 , Bernstein et al 2012 , Blevins et al 2013 ); Strepsirrhine primates ( Perret & Aujord 2005 ); rabbit ( Alexandersen et al 1999 ); mouse and rat ( van Weerden et al 1992 ); golden hamster ( Pieper & Lobocki 2000 ); spiny mouse ( Quinn et al 2013 ); Mongolian gerbil ( Fenske 1986 ) and Guinea pig ( Belanger et al 1989 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53

Nyce¹

2018

Endocrine-Related Cancer

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The activation of TP53 is well known to exert tumor suppressive effects. We have detected a primate-specific adrenal androgen-mediated tumor suppression system in which circulating DHEAS is converted to DHEA specifically in cells in which TP53 has been inactivated. DHEA is an uncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD), an enzyme indispensable for maintaining reactive oxygen species within limits survivable by the cell. Uncompetitive inhibition is otherwise unknown in natural systems because it becomes irreversible in the presence of high concentrations of substrate and inhibitor. In addition to primate-specific circulating DHEAS, a unique, primate-specific sequence motif that disables an activating regulatory site in the glucose-6-phosphatase (G6PC) promoter was also required to enable function of this previously unrecognized tumor suppression system. In human somatic cells, loss of TP53 thus triggers activation of DHEAS transport proteins and steroid sulfatase, which converts circulating DHEAS into intracellular DHEA, and hexokinase which increases glucose-6-phosphate substrate concentration. The triggering of these enzymes in the TP53-affected cell combines with the primate-specific G6PC promoter sequence motif that enables G6P substrate accumulation, driving uncompetitive inhibition of G6PD to irreversibility and ROS-mediated cell death. By this catastrophic ‘kill switch’ mechanism, TP53 mutations are effectively prevented from initiating tumorigenesis in the somatic cells of humans, the primate with the highest peak levels of circulating DHEAS. TP53 mutations in human tumors therefore represent fossils of kill switch failure resulting from an age-related decline in circulating DHEAS, a potentially reversible artifact of hominid evolution.

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Validation of Enzyme-Linked Immunosorbent Assay Techniques to Measure Serum Dehydroepiandrosterone (Dhea) and Dhea-S in Narwhals (Monodon Monoceros)

Béland¹,

Lair²,

Guay³

et al. 2023

Journal of Zoo and Wildlife Medicine

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Serum DHEA-S increases in dogs naturally infected with Ehrlichia canis

Cited by 3 publications

References 21 publications

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

Detection of a novel, primate-specific ‘kill switch’ tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53

Validation of Enzyme-Linked Immunosorbent Assay Techniques to Measure Serum Dehydroepiandrosterone (Dhea) and Dhea-S in Narwhals (Monodon Monoceros)

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