Serum Cytokine and Periodontal Profiles in Relation to Disease Activity of Rheumatoid Arthritis in Japanese Adults

Kobayashi, Tetsuo; Yokoyama, Tomoko; Ishida, Kohei; Abe, Asami; Yamamoto, Kouji; Yoshie, Hiromasa

doi:10.1902/jop.2010.090688

Cited by 63 publications

(71 citation statements)

References 34 publications

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“…Regarding the role of TNF-α in RA and CP, studies have indicated a positive relationship between TNF-α and RA and CP. Similar to TNF-α levels, proinflammatory cytokine levels in GCF and serum tend to increase with periodontal inflammation (14) and decrease after periodontal treatment in both CP and RA patients (29,30). Moreover, in another study, anti-TNF-α therapy in RA patients lowered GCF TNF-α levels and caused milder periodontal disease compared with patients who had not received anti-TNF-α therapy (31).…”

Section: Discussionmentioning

confidence: 91%

“…TNF-α plays a critical role in host response against a wide range of bacterial infections and contributes to both innate and adaptive immune responses in diseases such as CP and RA (14,28). Regarding the role of TNF-α in RA and CP, studies have indicated a positive relationship between TNF-α and RA and CP.…”

Section: Discussionmentioning

confidence: 99%

“…Complete understanding of disease pathogenesis of RA is challenging owing to itsplay major roles in the pathogenesis of RA and periodontitis. Besides, both diseases are chronic inflammatory diseases sharing certain pathogenetic mechanisms such as increased proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-11, IL-17, prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-α, resulting in bone loss (11)(12)(13)(14). Among these proinflammatory cytokines, TNF-α is particularly important as it plays a crucial role in hard and soft tissue destruction in both RA and chronic periodontitis (CP) (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis

et al. 2017

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The present study aimed to evaluate proinflammatory cytokine and vitamin D levels in rheumatoid arthritis (RA) and chronic periodontitis (CP) patients and healthy individuals before and after initial periodontal treatment. Overall, 17 CP patients with RA (RA + CP), 18 systemically healthy CP patients (CP), and 18 healthy controls (C) were included. Clinical periodontal measurements were recorded and gingival crevicular fluid (GCF) and blood samples were recorded. RA + CP and CP patients received nonsurgical periodontal treatment. Vitamin D, tumor necrosis factor (TNF)-α, receptor activator of nuclear factor-KB ligand (RANKL), and OPG levels were determined in GCF and serum. Baseline clinical parameters were similar in all periodontitis groups (P > 0.05) but were higher than that in controls (P < 0.05). Periodontal treatment improved clinical parameters in all periodontitis groups (P < 0.05). GCF vitamin D levels were higher in RA + CP and CP groups than in healthy controls, but these levels decreased in the RA + CP group after periodontal treatment (P < 0.05). Serum RANKL and GCF TNF-α levels in RA patients decreased after periodontal treatment (P < 0.05). Within the limitations of this study, the results suggested that GCF vitamin D levels are increased in RA patients and decrease after periodontal treatment; therefore, local vitamin D levels might be an important indicator of periodontal bone loss.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis

et al. 2017

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“…Studies in Sweden, Brazil, USA, Turkey, and Japan, however, did not find a higher prevalence and severity of periodontitis in RA patients [10][11][12][13][14] . In other words, the prevalence and severity of periodontitis in RA patients may be influenced by genetic, dietary, cultural and other differences associated with differences in nationality and ethnicity.…”

mentioning

confidence: 76%

“…Although various studies have assessed the association between periodontitis and RA [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] , no study has yet investigated the effect of using several definitions for periodontitis prevalence and severity on the association between periodontitis and RA.…”

mentioning

confidence: 99%

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Susanto

Nesse

Kertia

et al. 2013

Journal of Periodontology

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Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full‐mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age‐, sex‐, and smoking‐matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high‐sensitivity C‐reactive protein (hsCRP), rheumatoid factor, and anti‐citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti‐inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

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Interleukin‐6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors

Kobayashi

Ito

Kobayashi

et al. 2015

Clinical & Exp Dental Res

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Interleukin‐6 (IL‐6) may play a pathological role in rheumatoid arthritis (RA) and periodontitis. Although the efficacy of medication with IL‐6 receptor inhibitor, tocilizumab (TCZ), has been demonstrated in the treatment of RA, very little is known about whether TCZ therapy affects periodontitis. The aim of the present study is to compare periodontal condition in patients with RA and periodontitis before and after TCZ therapy. The study participants consisted of 20 patients with RA and periodontitis who were treated with TCZ and 40 patients with RA and periodontitis who received medication with tumor necrosis factor inhibitor (TNFI). Clinical periodontal and rheumatologic assessments and serum biochemical measurements using enzyme‐linked immunosorbent assays were performed at baseline and 3 and 6 months later. TCZ and TNFI therapies significantly reduced periodontal inflammation that was determined by gingival index, bleeding on probing, and probing depth (p < 0.017), although plaque levels were comparable before and after the therapies. Both therapies also significantly decreased disease activity score including 28 joints using C‐reactive protein (CRP), number of tender and swollen joints, and serum levels of anti‐cyclic citrullinated peptide antibodies, rheumatoid factor, CRP, and matrix metalloproteinase‐3 (p < 0.017). Additionally, a significant decrease was observed in periodontal clinical attachment level after TCZ therapy (p < 0.017), but not after TNFI therapy. TCZ therapy significantly decreased serum levels of TNF‐α, total immunoglobulin G, and serum amyloid A (p < 0.017), although serum levels of IL‐6 and soluble IL‐6R were significantly increased (p < 0.017). These results suggest a beneficial effect of TCZ therapy on levels of periodontal inflammation in patients with RA and periodontitis, which might be related to decrease in serum inflammatory mediators.

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Serum Cytokine and Periodontal Profiles in Relation to Disease Activity of Rheumatoid Arthritis in Japanese Adults

Abstract: These results suggest that the disease activity of RA correlated with serum levels of IL-6, TNF-alpha, and CRP, and it might influence BOP in the patients with moderate to high disease activity.

Cited by 63 publications

References 34 publications

Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis

Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Interleukin‐6 receptor inhibitor tocilizumab ameliorates periodontal inflammation in patients with rheumatoid arthritis and periodontitis as well as tumor necrosis factor inhibitors

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