Serum Copper Levels in Different Stages of Cervical Cancer in Manipur

Hijam, Davina; Dubey, Abhishek; Laishram, Victoria; Jaichand, L.; Devi, Th Ibetombi

doi:10.21276/ijmrp.2016.2.5.006

“…This result differs from a study where the authors observed that increased serum Cu levels were not modified after chemoradiotherapy in patients with CC [180]. In summary, Cu is indicated as a possible risk factor associated with CC that could be useful to monitor this type of cancer and potentially to control the progress of the disease [177][178][179].…”

Section: Uterine Diseases 221 Uterine Cervix Cancercontrasting

confidence: 82%

“…A meta-analysis recently documented the association between increased serum Cu levels and CC risk [177], and subsequently, this association was confirmed for cervical and endometrial cancers as well as OC. CC patients had the highest Cu concentrations [178], and this increase was positively correlated with the stages of the disease, while Cu decreased after different treatments (surgery, chemotherapy, radiotherapy, or a combination of both) [179]. This result differs from a study where the authors observed that increased serum Cu levels were not modified after chemoradiotherapy in patients with CC [180].…”

Section: Uterine Diseases 221 Uterine Cervix Cancermentioning

confidence: 60%

Copper in Gynecological Diseases

Conforti,

Delsouc,

Zorychta

et al. 2023

IJMS

4

0

View full text Add to dashboard Cite

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes’ and Wilson’s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.

show abstract

“…This result differs from a study where the authors observed that increased serum Cu levels were not modified after chemoradiotherapy in patients with CC [174]. In summary, Cu is indicated as a possible risk factor associated with CC that could be useful to monitor this type of cancer and potentially to control the progress of the disease [171][172][173].…”

Section: Uterine Cervix Cancercontrasting

confidence: 82%

“…A meta-analysis recently documented the association between increased serum Cu levels and CC risk [171], and subsequently, this association was confirmed for cervical and endometrial cancers as well as ovarian cancer. CC patients had the highest Cu concentrations [172], and this increase was positively correlated with the stages of the disease, while Cu decreased after different treatments (surgery, chemotherapy, radiotherapy, or a combination of both) [173]. This result differs from a study where the authors observed that increased serum Cu levels were not modified after chemoradiotherapy in patients with CC [174].…”

Section: Uterine Cervix Cancermentioning

confidence: 60%

Copper in Gynecological Diseases

Conforti,

Delsouc,

Zorychta

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes’ and Wilson’s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.

show abstract