Serum concentrations of TNF-alpha as a surrogate marker for malnutrition and worse quality of life in patients with gastric cancer

Correia, Marta; Cravo, Marília; Marques‐Vidal, Pedro; Grimble, Robert F.; Pereira, António Dias; Faias, Sandra; Nobre‐Leitão, Carlos

doi:10.1016/j.clnu.2007.08.014

Cited by 50 publications

(31 citation statements)

References 26 publications

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“…Nutritional interventions should therefore be recognised as an integral part of cancer therapy to improve clinical outcomes and quality of life (van Bokhorst-de van der Schueren, 2005). Early provision of nutritional support can stop or even reverse the decline in the nutritional status, and thus prevent the development of malnutrition and slowdown the progression of cachexia (Argiles, 2005;Correia et al, 2007). This is expected to lead to a better response to therapy and fewer treatment-related complications.…”

mentioning

confidence: 99%

Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia

et al. 2008

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The majority of patients with advanced cancer are recognised by impaired immune competence influenced by several factors, including the type and stage of the tumour and the presence of cachexia. Recently, a specific nutritional combination containing fish oil, specific oligosaccharide mixture, high protein content and leucine has been developed aimed to support the immune system of cancer patients in order to reduce the frequency and severity of (infectious) complications. In a recently modified animal model cachexia is induced by inoculation of C26 tumour cells in mice. In a pre-cachectic state, no effect was observed on contact hypersensitivity, a validated in vivo method to measure Th1-mediated immune function, after adding the individual nutritional ingredients to the diet of tumour-bearing mice. However, the complete mixture resulted in significantly improved Th1 immunity. Moreover, in a cachectic state, the complete mixture reduced plasma levels of pro-inflammatory cytokines and beneficially affected ex vivo immune function. Accordingly, the combination of the nutritional ingredients is required to obtain a synergistic effect, leading to a reduced inflammatory state and improved immune competence. From this, it can be concluded that the specific nutritional combination has potential as immune-supporting nutritional intervention to reduce the risk of (infectious) complications in cancer patients.

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confidence: 99%

Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia

et al. 2008

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“…Therefore, malnutrition is common in cancer patients. Over 30-75% of patients with gastric cancer are malnourished [30]. Due to effects of gastrectomies and cancer cell energy needs, malnutrition in GCPM patients is even more common.…”

Section: Discussionmentioning

confidence: 98%

Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

Zheng

Tong

et al. 2011

Clin Exp Metastasis

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Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Interstitial cells of Cajal (ICC) are apparently pacemaker cells, and their loss could cause motor dysfunction. In this study, we developed a mouse model for GCPM, and investigated electrophysiological changes in the small intestine and attendant changes in ICC. We found decreased ICC and disrupted electrical rhythm in the model. Pathologic ICC changes were well described. Cancer peritoneal metastasis may impair intestinal myoelectrical activity by damaging ICC and ICC networks. Interstitial cells of Cajal will be a target of palliative treatment and merit further study.

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“…In TNF-α-resistant cells, As 4 O 6 in combination with TNF-α showed synergism (data not shown). TNF-α is generally increased in patients with advanced and metastatic cancer and is associated with cancer progression and patient quality of life (14,15). Furthermore, TNF-α is abundantly released in chronic inflammatory disorders including rheumatoid arthritis as well, and a TNF-α inhibitor is used to control the chronic inflammatory disorders (24).…”

Section: Discussionmentioning

confidence: 99%

“…However, most cancer cells are resistant to TNF-α-induced cell death by activation of nuclear factor-κB (NF-κB) followed by the enhanced transcription of anti-apoptotic proteins that interfere with cell death signaling (13). High serum level of TNF-α is more frequently observed in patients with advanced and metastatic cancer than in those with early stage cancer (14), and is closely related to cancer progression and patient quality of life (14,15). In addition, NF-κB is involved in drug resistance as well as metastasis (16).…”

Section: Introductionmentioning

confidence: 99%

Arsenic hexoxide enhances TNF-α-induced anticancer effects by inhibiting NF-κB activity at a safe dose in MCF-7 human breast cancer cells

et al. 2014

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Abstract. Arsenic hexoxide (As 4 O 6 ) has been used in Korean folk remedy for the treatment of cancer since the late 1980s. Evidence suggests that the anticancer effects of As 4 O 6 are different from those of As 2 O 3 . Tumor necrosis factor-α (TNF-α) is generally increased in advanced cancer and is closely related to cancer progression, although it has cancer-killing effects. The reason is that TNF-α activates nuclear factor-κB (NF-κB) that is involved in cell proliferation, invasion, drug resistance and metastasis. In the present study, we investigated the effects of As 4 O 6 on NF-κB activity, NF-κB-mediated cellular responses, and NF-κB-regulated gene expressions involved in metastasis at the concentrations of As 4 O 6 where no cytotoxicity was observed. As 4 O 6 suppressed NF-κB activation in both TNF-α-treated and control cells, and also suppressed IκB phosphorylation in a time-dependent manner, suggesting the suppression of NF-κB results, in part, from the inhibition of IκB degradation. We also confirmed the anti-NF-κB activity of As 4 O 6 with synergism with TNF-α by augmenting caspase-8 activation. As 4 O 6 also suppressed NF-κB activation induced by TNF-α, and some of the downstream NF-κB-regulated proteins involved in cancer proliferation, anti-apoptosis and metastasis. In conclusion, the present study demonstrated that As 4 O 6 has anticancer properties by inhibiting NF-κB activation and NF-κB-regulated proteins at least in part through the inhibition of IκB phosphorylation, especially in the conditions of advanced cancer where TNF-α is highly secreted.

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Serum concentrations of TNF-alpha as a surrogate marker for malnutrition and worse quality of life in patients with gastric cancer

Cited by 50 publications

References 26 publications

Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia

Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia

Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

Arsenic hexoxide enhances TNF-α-induced anticancer effects by inhibiting NF-κB activity at a safe dose in MCF-7 human breast cancer cells

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