Serum concentrations of insulin, insulin‐like growth factor(IGF)‐I, IGF binding protein (IGFBP)‐1 and ‐3 and growth hormone binding protein in obese children: fasting IGFBP‐1 is suppressed in normoinsulinaemic obese children

Saitoh, Hisako; Kamoda, Tomohiro; Nakahara, Satomi; Hirano, Takeshi; Nakamura, Norimasa

doi:10.1046/j.1365-2265.1998.00476.x

Cited by 52 publications

(36 citation statements)

References 43 publications

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“…A recent study has suggested that suppression of the insulin-like growth factor-binding protein-1 (IGFBP-1) level due to hyperinsulinemia increases the level of free insulin-like growth factor-I (IGF-I) and promotes IGF-I's action, resulting in normal growth despite the reduced GH secretion in obese children (7). We have also reported that the serum IGFBP-1 level is suppressed in prepubertal obese children with fasting normoinsulinemia (8).…”

Section: Introductionmentioning

confidence: 62%

The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children

Kamoda

Saitoh²,

Nakahara³

et al. 1999

European Journal of Endocrinology

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Objective: We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their relationships to the IGFBP-1 phosphorylation status in obese subjects. Subjects and methods: Nineteen prepubertal obese and 15 age-matched control children were included in the study. The serum levels of total and nonphosphorylated IGFBP-1 were determined by noncompetitive RIAs. Results: The serum levels of total and nonphosphorylated IGFBP-1 were significantly lower in the obese group (48.7 Ϯ 5.6 mg/l, P < 0.001 and 11.1 Ϯ 1.9 mg/l, P < 0.01 respectively) than in the controls (86.7 Ϯ 9.0 mg/l and 28.8 Ϯ 6.2 mg/l respectively). However, the ratio of nonphosphorylated IGFBP-1 to total IGFBP-1 did not differ significantly between the obese and control groups. The circulating free IGF-I level was significantly higher in the obese children than in the controls (P < 0.05), while the serum levels of insulin, total IGF-I and IGFBP-3 were not significantly different between the two groups. A stepwise regression analysis of the combined group revealed that only the total IGFBP-1 level was an independent predictor of the free IGF-I concentration (P < 0.001).Conclusion: The present study shows that both total and nonphosphorylated IGFBP-1 concentrations are decreased in obese children and the increased free IGF-I level in obese children is related to the reduced total IGFBP-1 level, but unrelated to the change in the IGFBP-1 phosphorylation status.

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Section: Introductionmentioning

confidence: 62%

The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children

Kamoda

Saitoh²,

Nakahara³

et al. 1999

European Journal of Endocrinology

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“…Circulating IGF-I levels in obese subjects would be expected to be low, because growth hormone (GH) stimulates the liver to produce IGF-I and because there is an inverse relationship between obesity and GH secretion. However, findings of studies on obese subjects are conflicting, with serum concentrations of total IGF-I reported to be relatively low, 13-16 unchanged 17,18 or increased. 19,20 Several crosssectional studies of adiposity and circulating IGF-I have found no relationship [21][22][23][24][25][26][27][28][29][30][31][32] while a nonlinear relationship of body mass index (BMI) with IGF-I has been observed in some large studies.…”

Section: Introductionmentioning

confidence: 99%

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

et al. 2006

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Objective: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulinlike growth factor-I (IGF-I), and its binding protein (IGFBP)-3. Design: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzymelinked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. Results: Adjusted mean serum IGF-I values were lower in women with BMIo22.5 kg/m 2 or BMI429.2 kg/m 2 compared to women with BMI within this range (P heterogeneity o0.0001, P trend ¼ 0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P trend ¼ 0.005). Conclusions: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to nonobese women and inversely related to central adiposity.

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“…Malnutrition is associated with a state of GH resistance (Soliman et al, 1986). On the other hand, obesity leads to lower GH but high to normal IGF-I levels in children (Loche et al, 1987;Argente et al, 1997;Falorni et al, 1997;Saitoh et al, 1998). In developing countries, malnutrition is more common in children from lower socioeconomic levels and the obesity is more common in children from higher socioeconomic levels (Gross et al, 1990;Peck and Lundberg, 1995;Nebigil et al, 1997;Hakeem, 2001;Ulukanligil and Seyrek, 2004a).…”

Section: Introductionmentioning

confidence: 99%

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

et al. 2006

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Objectives: The effect of economic status (ES) on growth, insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in healthy children is not well characterized. We aimed to study the interrelationship between height, weight, IGF-I, IGFBP-3, mid-parental height (MPH) and ES. Design/subjects: Eight hundred and fourteen healthy children (428 boys, 386 girls; age 3-18 years) were classified according to income of the families as low, middle and high. Standard deviation scores (SDSs) of height, weight, MPH, IGF-I and IGFBP-3 were compared between the groups. The combined effect of these parameters and ES on height SDS was investigated with complex statistical models. Results: There was a significant trend for height and weight SDSs to increase with higher income levels in boys, but not in girls. Body mass index (BMI) SDSs were similar in three groups. There was a general trend for MPH SDS to increase with income levels in both sexes. In boys, IGF-I SDS was significantly higher in high ES group than low ES. In girls, IGFBP-3 SDSs were significantly higher in high ES group than in middle ES group. For both genders, height SDS was highly correlated with weight SDS and moderately correlated with BMI SDS, MPH SDS and IGF-1 SDS. All correlations were significant and positive. Complex models showed that MPH (19%), IGF-I (13%) and ES (3%) in boys, and MPH (16%) and IGF-I (7%) in girls have significant contribution to height SDSs. Conclusions: ES per se, independent of overt malnutrition, affects height, weight, IGF-I and IGFBP-3 with some gender differences in healthy children. Influence of income on height and weight show sexual dimorphism, a slight but significant effect is observed only in boys. MPH is the most prominent variable effecting height in healthy children. Higher height and MPH SDSs observed in higher income groups suggest that secular trend in growth still exists, at least in boys, in a country of favorable economic development.

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Serum concentrations of insulin, insulin‐like growth factor(IGF)‐I, IGF binding protein (IGFBP)‐1 and ‐3 and growth hormone binding protein in obese children: fasting IGFBP‐1 is suppressed in normoinsulinaemic obese children

Cited by 52 publications

References 43 publications

The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children

The phosphorylation status of insulin-like growth factor-binding protein-1 in prepubertal obese children

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

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