Serum Concentrations of DDT and DDE among Malaria Control Workers in the Amazon Region

Ferreira, Celso P.; De-Oliveira, A.C.A.X.; Paumgartten, Francisco José Roma

doi:10.1539/joh.o10026

Cited by 17 publications

(6 citation statements)

References 14 publications

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“…The median half-life of the DDT metabolite p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) among Brazilian malaria control workers was 28 months, although with large inter-individual variations (Ferreira et al 2011). Using serum from former capacitor workers, Seegal et al found that the geometrical mean halflives over a study period from 1976 to 2004 were 17.8 years for the heavy PCB congeners (i.e., PCBs eluting before DDE using gas chromatography) and 9.6 years for the light congeners (i.e., PCBs eluting after DDE using gas chromatography) (Seegal et al 2011).…”

Section: Responsible Editor: Hongwen Sunmentioning

confidence: 99%

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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The use of the lipophilic persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs) and several organochlorine pesticides (OCPs) has been prohibited for more than 30 years. In this study, we present the temporal trends of the lipophilic POP serum concentrations in Danish nulliparous pregnant women between 2011 and 2013. We randomly selected 197 pregnant women (gestational age 11-13) from the Aarhus Birth Cohort. The concentrations of the lipophilic POPs in the serum samples were analyzed using gas chromatography. The concentrations were corrected for total serum lipids. The statistical analysis was performed by regression analysis with adjustment for age, BMI, gestational age at blood draw, and smoking status. The serum concentrations of PCB 118, 138, 153, 156, 170, 180, 187, and hexachlorobenzen, trans-nonachlor, β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene were lower in 2013 than in 2011. However, the oxychlordane concentration was lowest in 2011. The serum levels of most lipophilic POPs followed downward trends during the study period, which was expected, as these compounds has been banned for many years. The upward trend of oxychlordane was unexpected and presumably a chance finding.

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Section: Responsible Editor: Hongwen Sunmentioning

confidence: 99%

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Bjerregaard-Olesen

Long

Ghisari

et al. 2017

Environ Sci Pollut Res

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“…We used PCB-153 as a biomarker of PCB exposure because concentrations of this PCB congener are relatively high and highly correlated with the total molar concentration of PCBs (Glynn et al 2000; Muckle et al 2001; Needham et al 2011). The elimination half-life of PCB-153 is > 10 years (Ritter et al 2011 and that of p , p ´-DDE, the major metabolite of DDT, is approximately 5 years (Ferreira et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts

Govarts

Nieuwenhuijsen

Schoeters

et al. 2012

Environ Health Perspect

280

187

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Objectives: Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contrasts and appropriate exposure assessment are warranted. Within the framework of the EU (European Union) ENRIECO (ENvironmental Health RIsks in European Birth Cohorts) and EU OBELIX (OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight.Methods: We used maternal and cord blood and breast milk samples of 7,990 women enrolled in 15 study populations from 12 European birth cohorts from 1990 through 2008. Using identical variable definitions, we performed for each cohort linear regression of birth weight on estimates of cord serum concentration of PCB-153 and p,p´-DDE adjusted for gestational age and a priori selected covariates. We obtained summary estimates by meta-analysis and performed analyses of interactions.Results: The median concentration of cord serum PCB-153 was 140 ng/L (range of cohort medians 20–484 ng/L) and that of p,p´-DDE was 528 ng/L (range of cohort medians 50–1,208 ng/L). Birth weight decreased with increasing cord serum concentration of PCB-153 after adjustment for potential confounders in 12 of 15 study populations. The meta-analysis including all cohorts indicated a birth weight decline of 150 g [95% confidence interval (CI): –250, –50 g] per 1-µg/L increase in PCB-153, an exposure contrast that is close to the range of exposures across the cohorts. A 1-µg/L increase in p,p´-DDE was associated with a 7-g decrease in birth weight (95% CI: –18, 4 g).Conclusions: The findings suggest that low-level exposure to PCB (or correlated exposures) impairs fetal growth, but that exposure to p,p´-DDE does not. The study adds to mounting evidence that low-level exposure to PCBs is inversely associated with fetal growth.

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“…Despite regulatory measures and due to their long half-lives, these compounds are still ubiquitous in the environment and detected in a variety of human tissues and fluids (Malisch and Kotz, 2014). The human elimination half-lives of PCB 153, p,p'-DDE, HCB, PFOS and PFOA are > 10 years (Ritter et al, 2011), 5 years (Ferreira et al, 2011),~6 years (To-Figueras et al, 2000), 5 years (Olsen et al, 2007), and 3.5 years (Olsen et al, 2007), respectively. Due to their high lipophilicity (organochlorine compounds) or amphoteric properties (perfluorinated compounds) these compounds are transported via the placenta to the fetus and can also reach the infant through maternal milk (Stefanidou et al, 2009;WHO/UNEP, 2013).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts

Govarts

Iszatt

Trnovec

et al. 2018

Environment International

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Serum Concentrations of DDT and DDE among Malaria Control Workers in the Amazon Region

Cited by 17 publications

References 14 publications

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013

Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts

Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts

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