Serum concentrations of acute-phase proteins in dogs with leishmaniosis during short-term treatment

Martı́nez-Subiela, Silvia; Bernal, Luis J.; Cerón, José J.

doi:10.2460/ajvr.2003.64.1021

Cited by 68 publications

(89 citation statements)

References 23 publications

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“…These results are in agreement with previous reports in which a possible stimulation in the synthesis of this protein caused by different drugs such as antihelmintics (Tosa et al, 1993), meglumine antimoniate (Martinez-Subiela et al, 2003a), glucocorticoids and cytotoxic drugs (McGrotty et al, 2003) was suggested.…”

Section: Discussionsupporting

confidence: 83%

“…Among these, the index CRP*CP/Alb was selected as the optimum since it showed a greater and faster decrease (78% decrease on day 10) compared with the others. Moreover, the magnitude of the decrease of that index on day 10 was greater than that reported for individual acute phase proteins (44% for CRP and 58% for CP) (Martinez-Subiela et al, 2003a). This finding suggest that the combination of both positive acute phase proteins (CRP and Cp) with a negative one could have a greater potential as a biomarker to evaluate the early response to therapy in canine leishmaniasis compared to the individual proteins alone.…”

Section: Discussionmentioning

confidence: 41%

“…It has been reported that although most dogs with leishmaniosis have high concentrations of the distinct acute phase proteins, sensitivities do not reach 100% (Martinez-Subiela et al, 2003a). However, the use of indexes in which different acute phase proteins are combined could provide better sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…Monitoring the plasma concentrations of acute phase proteins have been reported to be useful in the evaluation of the response to therapy in canine leishmaniasis (Martinez-Subiela et al, 2003a). Their interpretative benefit can be further enhanced by the acute phase index calculated as a ratio between positive and negative reacting acute phase proteins (Skinner, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that measurements of selected acute phase proteins such as C-reactive protein (CRP) and/or ceruloplasmin (CP) could be used to evaluate the initial response to treatment in canine leishmaniasis since these proteins significantly decreased in concentration when the treatment is successful and it has been postulated that acute phase proteins could have a greater potential as biomarkers for monitoring the response to treatment compared to the albumin-globulin ratio (Martinez-Subiela et al 2003a). The aim of this study, was the evaluation of acute phase protein indexes in dogs with leishmaniasis before, during and after short-term treatment.…”

Section: Evaluation Of Acute Phase Protein Indexes In Dogs With Leishmentioning

confidence: 99%

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Evaluation of acute phase protein indexes in dogs with leishmaniasis at diagnosis, during and after short-term treatment

Martı́nez-Subiela¹,

Cerón²

2005

Vet. Med. - Czech

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An acute phase index based on a combination of acute phase proteins which permitted monitoring the response to therapy of canine leishmaniasis was developed and evaluated in this study. Six dogs naturally infected by Leishmania infantum were treated with meglumine antimoniate (Glucantime  , Merial, Lyon, France) 100 mg/kg/day sc, given concurrently for 20 days with allopurinol (Zyloric  , Glaxo Wellcome, Madrid, Spain) 30 mg/kg/day po and then, allopurinol alone for one month at the same dosage. Blood samples for acute phase proteins were obtained on different days before and after the beginning of treatment and two groups of indexes were calculated: (1) Indexes that combined one positive and one negative acute phase protein and (2) Indexes that combined two positive and one negative acute phase proteins. All calculated indexes were significantly higher in animals with leishmaniasis compared with clinically healthy dogs (n = 8) and a decrease was observed in all dogs tested during the treatment. Indexes that combined C-reactive protein (CRP) and ceruloplasmin (CP) with other proteins showed greater percentages of decrease that were statistically significant. Among these, the index CRP*CP/Alb was selected as the optimum since it showed a larger and faster decrease compared with the others as well as with individual proteins alone. These results would support the use of selected acute phase indexes, especially the CRP*CP/Alb index, to suspect about a leishmaniotic dogs and to monitor their response to treatment.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Of Acute Phase Protein Indexes In Dogs With Leishmentioning

confidence: 99%

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