2018
DOI: 10.18632/aging.101512
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Abstract: Since early diagnosis is very important for treating CRC, we decided to detect peripheral serum canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform 2 to verify its diagnostic value for CRC patients. Serum samples were collected from 430 CRC patients and 201 healthy controls. Enzyme-linked immunosorbent assay (ELISA) detection kits for CNPY2 isoform 2 were generated and then applied to measure serum CNPY2 isoform 2 concentrations. Serum carcinoembryonic antigen (CEA) and carbohydrate antigen 1… Show more

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Cited by 7 publications
(4 citation statements)
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References 26 publications
(31 reference statements)
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“…Several genes have been identified to be dysregulated and associated with tumor progression in CRC. For example, serum CNPY2 isoform 2 was revealed to be upregulated in tumor samples and served as a novel biomarker for early detection of CRC (29). miR-6852 was downregulated and correlated with an improved prognosis for patients with CRC (30).…”
Section: Discussionmentioning
confidence: 99%
“…Several genes have been identified to be dysregulated and associated with tumor progression in CRC. For example, serum CNPY2 isoform 2 was revealed to be upregulated in tumor samples and served as a novel biomarker for early detection of CRC (29). miR-6852 was downregulated and correlated with an improved prognosis for patients with CRC (30).…”
Section: Discussionmentioning
confidence: 99%
“…CNPY2 may represent a prognostic indicator for CRC [ 31 ]. Serum CNPY2 is considered as a valuable diagnostic biomarker in CRC screening [ 32 ]. GRB10, which encodes an adaptor protein, modulates the coupling of multiple cell surface receptor kinases involved in specific signaling pathways.…”
Section: Discussionmentioning
confidence: 99%
“…Although colonoscopy is the criterion standard for CRC screening, with a high diagnostic value, it is an invasive method that requires bowel preparation and experienced operators [3]. To date, several other biomarkers have also used to screen for CRC, including CPNE3 [4], CNPY2 isoform 2 [5], and SATB2 [6]; however, few have sufficiently satisfactory performance for clinical use. Therefore, the search for more patient-friendly and less-invasive approaches with high sensitivity and specificity is imperative to improve CRC patients’ outcome.…”
Section: Introductionmentioning
confidence: 99%