Serum carcinoembryonic antigen level in non-small-cell lung cancer patients with preoperative normal serum level

Abstract

NSCLC patients with a high serum CEA level, especially adenocarcinoma patients, had poorer prognosis even if their serum CEA levels were within the normal upper limit.

CEA is an Independent Prognostic Indicator that is Associated with Reduced Survival and Liver Metastases in SCLC

“…CEA expression has been reported to be a prognostic indicator in colorectal cancer and has also been used to monitor colorectal cancer patients in remission for early signs of recurrence [14][15][16]. A recent study reported that CEA expression was correlated with prognosis in NSCLC patients, especially adenocarcinoma patients [11,12]. We found CEA expression to be a strong prognostic indicator, with P \ 0,001 in both univariate and multivariate analyses.…”

“…This marker is not specific for SCLC, and few studies link this marker to the survival of SCLC. Two recent reports suggest that NSCLC patients with a high serum CEA level, especially adenocarcinoma patients, had a poorer prognosis [11,12]. In this study, we identified CEA as a prognostic indicator independent of tumor stage and found that it was associated with reduced survival time and an increased incidence of liver metastases.…”

The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung

“…Many authors reported that NSCLC patients with a high serum CEA concentration have a poor prognosis [16][17][18][19][20], but there are few reports in N1 disease. Tomita et al reported that a serum CEA level of more than 10 ng/ml was an independent overall prognostic factor in pN1 patients and was significantly related to survival in pT1-2N1M0 NSCLC (the normal upper limit of CEA level was 5 ng/ml) [13]. In our study, serum CEA cutoff levels of both 3 ng/ml and 5 ng/ml showed prognostic significance ( p = 0.0148 and 0.0015, respectively).…”

“…It has been reported that the elevation of preoperative serum CEA levels is associated with more advanced disease and poorer prognosis even after successful surgical procedure [11][12]. However, there are few reports that focused on the serum CEA level in N1 NSCLC patients [13].…”

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

“…There is some controversy regarding the optimal prognostic cutoff point. However, the diagnostic cut off, indicating the normal upper limit for the healthy population was used as a prognostic cut off in some studies [46,47].…”