Serum carbohydrate sulfotransferase 7 in lung cancer and non-malignant pulmonary inflammations

Debeljak, Željko; Dundović, Sandra; Badovinac, Sonja; Mandić, Sanja; Samaržija, Miroslav; Dmitrović, Branko; Miloš, Marija; Maričić, Lana; Šerić, Vatroslav; Buljanović, Vikica

doi:10.1515/cclm-2017-1157

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…Fewer studies has reported CHST7 was associated with carcinogenic process. A previous literature uncovered that serum CHST7 was significantly increased in all overall stages of primary lung tumors [ 37 ]. In addition, Bi et al reported that methylation level of CHST7 in white blood cells was correlated to colorectal cancer risk [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7

Wang

2022

Aging

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Chemoresistance leads the cause of poor outcome of patients with gastric cancer (GC). Long non-coding RNAs (LncRNAs) is intimately involved in the regulation of tumorigenesis and progression. Here, we demonstrated ZNF674-AS1 was down-regulated in oxaliplatin (OXA)-resistant tissues and cell lines, lower level of ZNF674-AS1 predicted poor prognosis of GC patients. Besides, forced expression of ZNF674-AS1 not only reduced cell viability, colony formation, expression of drug-resistant markers but also promoted cell apoptosis of OXA-resistant GC cells, exposed to oxaliplatin. Silence of ZNF674-AS1 exhibited an opposite effects on OXA resistance of GC cells. Further mechanistic research showed that ZNF674-AS1 interacted with EZH2, led to higher methylation level of target gene CHST7. In addition, functional experiments verified that depletion of CHST7 re-sensitized OXA-resistant GC cells to OXA. Thus, our results indicated that ZNF674-AS1 suppressed OXA resistance of GC through EZH2-mediated inhibition of CHST7, providing potential theoretic basis and therapeutic strategy for chemoresistant GC.

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7

Wang

2022

Aging

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“…Chemotherapy can also cause stomatitis, sore throat, inflammation of the gastrointestinal mucosa, and liver dysfunction, aggravating the degree of malnutrition (Miyata et al, 2017;Debeljak et al, 2018;Yu et al, 2017;Chao et al, 2017). Some patients therefore refuse treatment or are forced to terminate treatment.…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation treatment of enteral nutrition whey protein in lung cancer patients in southern China

Zhao

Zhan

2021

Food Sci. Technol

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“…The activity-dependent remodeling of CSPGs’ main extracellular matrix (ECM) could be involved in the structural plasticity of the hypothalamo-neurohypophysial system [ 6 ]. Carbohydrate sulfotransferase 7 (CHST7) transfers the sulfate to carbohydrate groups in glycoproteins and involved in carcinogenesis by controlling the biosynthesis of CSPGs [ 7 ]. The CHST7 promoter hypermethylation increased the risk of colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

“…The CHST7 promoter hypermethylation increased the risk of colorectal cancer. Serum CHST7 will be used for the differentiation between lung cancer and non-malignant pulmonary inflammation [ 7 ]. The level of CHST7 was noticeably altered in the breast epithelial cell line MCF-10F after parathion treatment, which has a synergistic effect with estrogen [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

CHST7 Methylation Status Related to the Proliferation and Differentiation of Pituitary Adenomas

Dong

Shi

Liu

et al. 2022

Cells

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Pituitary adenomas (PAs) are the second most common primary brain tumor and may develop from any of the cell lineages responsible for producing the different pituitary hormones. DNA methylation is one of the essential epigenetic mechanisms in cancers, including PAs. In this study, we measured the expression profile and promoter methylation status of carbohydrate sulfotransferase 7 (CHST7) in patients with PA; then, we investigated the effect of the CHST7 methylation status on the proliferation and differentiation of PAs. The volcano map and Metascape results showed that the levels of CHST7 were related to the lineages’ differentiation and the cell adhesion of PAs, and patients with low CHST7 had greater chances of having an SF-1 lineage (p = 0.002) and optic chiasm compression (p = 0.007). Reactome pathway analysis revealed that most of the DEGs involved in the regulation of TP53 regulated the transcription of cell cycle genes (HSA-6791312 and HSA6804116) in patients with high CHST7. Correlation analysis showed that CHST7 was significantly correlated with the eIF2/ATF4 pathway and mitochondrion-related genes. The AUC of ROC showed that CHST7 (0.288; 95% CI: 0.187–0.388) was superior to SF-1 (0.555; 95% CI: 0.440–0.671) and inferior to FSHB (0.804; 95% CI: 0.704–0.903) in forecasting the SF-1 lineage (p < 0.001). The SF-1 lineage showed a higher methylation frequency for CHST7 than the Pit-1 and TBX19 lineages (p = 0.009). Furthermore, as the key molecule of the hypothalamic–pituitary–gonadal axis, inhibin βE (INHBE) was positively correlated with the levels of CHST7 (r = 0.685, p < 0.001). In summary, CHST7 is a novel pituitary gland specific protein in SF-1 lineage adenomas with a potential role in gonadotroph cell proliferation and lineage differentiation in PAs.

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Serum carbohydrate sulfotransferase 7 in lung cancer and non-malignant pulmonary inflammations

Abstract: Serum CHST7 is a promising biomarker for the differentiation between lung cancer and non-malignant pulmonary inflammations.

Cited by 9 publications

References 28 publications

Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7

Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7

Rehabilitation treatment of enteral nutrition whey protein in lung cancer patients in southern China

CHST7 Methylation Status Related to the Proliferation and Differentiation of Pituitary Adenomas

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