Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population

Makita, Shinji; Nakamura, Motoyuki; Satoh, Kenyu; Tanaka, Fumitaka; Onoda, Toshiyuki; Kawamura, Kazuko; Ohsawa, Masaki; Tanno, Kozo; Itai, Kazuyoshi; Sakata, Kiyomi; Okayama, Akira; Terayama, Yasuo; Yoshida, Yuki

doi:10.1016/j.atherosclerosis.2008.07.040

Cited by 66 publications

(57 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…But inclusion of diabetes in a model that predicted all-cause mortality by elevated GGT levels did not affect the esti- mates, as well as inclusion of a summative CVD score. Despite previous studies suggesting a direct association of serum GGT with CRP, 38 and growing evidence that hs-CRP acts as an independent mortality risk factor, 44,45 our mediation analyses with the inclusion of hs-CRP only modestly changed the estimates. Sensitivity analysis considering alcohol consumption also lacked an impact on the pathway from GGT to mortality, suggesting that elevated GGT levels acts as an independent risk factor for mortality.…”

Section: Discussioncontrasting

confidence: 84%

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

et al. 2009

View full text Add to dashboard Cite

The aim of the present study was to investigate the association of serum gamma-glutamyltransferase (GGT) levels with all-cause mortality and to assess the impact of ultrasonographic findings of hepatic hyperechogenicity in that association. We used data from 4,160 subjects (2,044 men and 2,116 women) recruited for the population-based Study of Health in Pomerania (SHIP) without baseline hepatitis B and C infections or liver cirrhosis. GGT was divided into age-and sex-dependent quintiles to calculate overall and sex-specific crude incidence mortality rates. Hepatic steatosis was defined by elevated GGT levels (>80%) and the presence of hyperechogenic liver ultrasound. We used multiple-adjusted Cox proportional hazards regression models, first, to assess the direct effect of GGT on all-cause mortality, second, to stratify according to the ultrasonographic finding, and third, to investigate potential mediating effects of cardiometabolic risk factors. During 29,810 person-years (7.3 years, median) of follow-up, 307 individuals (7.5%) died, resulting in a death rate of 0.86 deaths per 1000 person-years. Elevated GGT levels were associated with increased risk of mortality in men (hazard ratio [HR] 1.49; 95% confidence interval [CI], 1.08-2.05), but not in women (HR 1.30; 95% CI, 0.80-2.12). This association was even stronger in men with hepatic steatosis (HR 1.98; 95% CI, 1.21-3.27). Cause-specific mortality analysis by cardiovascular disease deaths confirmed the sex-specific association. Adjustment for cardiometabolic risk factors did not affect the estimates. Conclusion: In the case of increased GGT levels, liver ultrasound should be performed, not only for diagnosis, but also for further risk stratification.

show abstract

Section: Discussioncontrasting

confidence: 84%

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Elevated inflammatory biomarkers, including interleukin 6 (IL-6) and TNFa, have been associated with all-cause death and cancer death in several studies (3)(4)(5)(6)(7). Elevated hs-CRP levels are also shown to be associated with increased risks of all-cause death (8)(9)(10) and cancer death in several studies (9,11). Some studies have suggested that hs-CRP acts as a survival predictor in cancer patients (6,11,12).…”

Section: Introductionmentioning

confidence: 99%

“…Most of the studies on the influence of hs-CRP on cancer mortality have originated from western countries (7)(8)(9)(10)(11)(12). The common causes of cancer mortality among Koreans, however, appear to differ from those of people in other countries.…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein Levels and Cancer Mortality

Kwon

Kim

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: High-sensitivity C-reactive protein (hs-CRP) is an important inflammatory marker, and inflammation is known to be involved in the initiation and progression of cancer. We investigated the association between serum hs-CRP levels and all-cause mortality, cancer mortality, and site-specific cancer mortality in apparently cancer-free Koreans.Methods: A total of 33,567 participants who underwent routine check-ups at a single tertiary hospital healthscreening center between May 1995 and December 2006, and whose serum hs-CRP level data were available, were included in the study. Baseline serum hs-CRP levels were obtained and subjects were followed up for mortality from baseline examination until December 31, 2008.Results: During an average follow-up of 9.4 years, 1,054 deaths, including 506 cancer deaths, were recorded. The adjusted HRs (aHR; 95% confidence interval [CI]) of subjects with hs-CRP !3 mg/L for all-cause and cancer-related mortality were 1.38 (1.15-1.66) and 1.61 (1.25-2.07) in men, and 1.29 (0.94-1.77) and 1.24 (0.75-2.06) in women, respectively, compared with subjects with hs-CRP 1 mg/L. Elevated hs-CRP was also associated with an increased risk of site-specific mortality from lung cancer for sexes combined (2.53 [1.57- 4.06]).Conclusions: This study suggests that elevated levels of hs-CRP in apparently cancer-free individuals may be associated with increased mortality from all-causes and cancer, in particular, lung cancer in men, but not in women.Impact: As a marker for chronic inflammation, hs-CRP assists in the identification of subjects with an increased risk of cancer death. Cancer Epidemiol Biomarkers Prev; 21(11); 2076-86. Ó2012 AACR.

show abstract

“…Survey methods have been described in detail previously 15,16) . The baseline survey was conducted from April 2002 to January 2005.…”

Section: Study Participantsmentioning

confidence: 99%

“…Investigators reviewed the population register of each local government and confirmed dates of death and locations to which participants had relocated. Persons known to be alive at the end of follow-up and those who had moved away from the study areas were treated as censored cases 16) . We confirmed that approximately 99.9% of participants who were registered at the baseline were alive.…”

Section: Outcome Measuresmentioning

confidence: 99%

Serum Low-Density Lipoprotein to High-Density Lipoprotein Ratio as a Predictor of Future Acute Myocardial Infarction Among Men in a 2.7-Year Cohort Study of a Japanese Northern Rural Population

Yokokawa

Yasumura

Tanno

et al. 2011

JAT

Self Cite

View full text Add to dashboard Cite

Aim: To examine and compare the predictive value of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TC/HDL-C and LDL-C/HDL-C ratios for future cardiovascular outcomes in the general Japanese population. Methods: A total of 24,566 eligible participants aged 18 years or older, without cardiovascular disease, were enrolled through multiphase health screening and divided into quartile groups based on lipoprotein levels or ratios. Primary endpoints of the study were definitive acute myocardial infarction (AMI) and ischemic stroke, and cases of sudden death with unknown causes were not included. We used Cox proportional hazard models to examine the relationships between the quartiles and incidences of AMI or ischemic stroke, adjusting for traditional risk factors. Results: Mean age was 63.7 years for males and 60.7 years for females. Mean follow-up period was 2.7 years, and 40 cases of AMI and 182 cases of ischemic stroke were recorded. The hazard ratio (HR) for AMI was significantly higher in the top quartile of the LDL-C/HDL-C ratio and LDL-C levels, and third quartile of TC among male participants. The HR of male participants with a LDL-C/HDL-C ratio of 2.6 or higher was significantly higher than other quartiles. No association between lipoprotein levels or their ratio quartiles and ischemic stroke was seen for either sex after adjusting for risk factors. Conclusions: Our results indicated that the LDL-C/HDL-C ratio is an independent predictor for AMI, and the importance of better management of cardiovascular risks among people with high LDLC/HDLC ratios for the prevention of future cardiovascular disease. J Atheroscler Thromb, 2011; 18:89-98.

show abstract

Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population

Cited by 66 publications

References 21 publications

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

High-Sensitivity C-Reactive Protein Levels and Cancer Mortality

Serum Low-Density Lipoprotein to High-Density Lipoprotein Ratio as a Predictor of Future Acute Myocardial Infarction Among Men in a 2.7-Year Cohort Study of a Japanese Northern Rural Population

Contact Info

Product

Resources

About