Serum C-reactive protein/albumin ratio and restless legs syndrome

Yazar, Hülya Olgun; Yazar, Tamer; Özdemir, Sonay İncesoy; Arıcı, Yeliz Kaşko

doi:10.1016/j.sleep.2019.02.022

Cited by 28 publications

(22 citation statements)

References 37 publications

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“…At the same time, there are studies assessing CRP concentration in RLS patients. One of them was performed to investigate CRP concentration in individuals with RLS in general and revealed its increased levels compared to controls [57]. On the other hand, we found another study that could be applicable to our findings, but it investigated possible correlation particularly between periodic leg movements (PLMs) of sleep in RLS and CRP concentration.…”

Section: Discussionmentioning

confidence: 76%

The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis—A Questionnaire-Based Cross-Sectional Analysis

Nowowiejska

Baran

Lewoc

et al. 2021

JCM

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Psoriasis is a chronic, inflammatory skin disease affecting 2–4% of the general population. Accompanying subjective symptoms (pruritus or pain) may cause decreased life quality including sleep disorders (SD). Sixty psoriatic patients fulfilled the following questionnaires: Pittsburgh Sleep Quality Index (PSQI), STOP BANG for the obstructive sleep apnea syndrome (OSAS) assessment, and Restless Legs Syndrome (RLS) Severity Scale. Patients’ laboratory and clinical data were also investigated. All data obtained were compared to 40 participants without dermatoses. Mean PSQI, risk of OSAS, and RLS severity of psoriatics were significantly higher than in controls (p < 0.0001, p < 0.05, p < 0.05 respectively). There was a positive correlation between the time of suffering from psoriasis and the risk of OSAS (R = 0.286, p < 0.05). We did not observe any significant relationship between PSQI, risk of OSAS, or RLS and psoriasis severity assessed with PASI (Psoriasis Area and Severity Index). We identified four possible predictors of RLS: glucose, CRP and total cholesterol concentrations, and PSQI. SD are significantly more frequent in psoriatics than in people without chronic dermatological diseases but surprisingly they are not correlated with psoriasis severity. SD decrease patients’ life quality and may result in serious consequences. Therefore, establishing recommendations concerning screening for SD and their predictors should be considered.

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Section: Discussionmentioning

confidence: 76%

The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis—A Questionnaire-Based Cross-Sectional Analysis

Nowowiejska

Baran

Lewoc

et al. 2021

JCM

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“…The principal findings of the present study were that CAR, NAR, NLR, PLR, MLR, RDW, and MPV were peripheral inflammatory markers that were increased in a relatively large sample of patients with schizophrenia compared with healthy controls. Despite CAR values having been recently reported in patients with Parkinson disease, 19 restless leg syndrome, 18 and migraine, 17 this is the first study to examine CAR and NAR in patients with with schizophrenia.…”

Section: Discussionmentioning

confidence: 90%

“…15,16 Previously, CAR has been studied in several neurological illnesses including Parkinson's disease, migraine, and restless leg syndrome, and these studies have suggested that CAR might reflect increased inflammatory status in such neurological conditions. [17][18][19] In a recent study, the association between depression severity and CAR has been examined in patients diagnosed lung cancer. 20 However, to date, CAR has not been studied in schizophrenia or other psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

Balcıoğlu

Kırlıoğlu

2020

Psychiatry Investig

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Objective Peripheral biomarker studies in schizophrenia are insufficient to correspond to whether inflammatory markers are trait- or state-related. The main objective of this study was to compare novel biomarkers C-reactive protein/albumin ratio (CAR), neutrophil/albumin ratio (NAR), and complete blood count-derived inflammatory markers; neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), red-cell distribution width (RDW), and mean platelet volume (MPV) between patients with acutely exacerbated and remitted schizophrenia and healthy controls.Methods Anonymous data of a total of 618 patients with schizophrenia (179 in remission, 439 with acute exacerbation) and 445 psychiatrically and medically healthy subjects admitted to outpatient units were included. One-way ANOVA with Tukey’s HSD post-hoc test, Pearson’s correlation test, receiver operating characteristic analysis, and binomial logistic regression analysis were performed.Results CAR, NAR, NLR, PLR, MLR, RDW, MPV values were found higher in patients with schizophrenia than in healthy subjects. Except for NAR (p=0.007), none of the markers differed between acute exacerbation and remission. As a cut-off value of CAR, 0.388 differentiated patients with schizophrenia from controls (sensitivity 81%, specificity 81%). CAR, NAR, and MPV significantly predicted the diagnosis of schizophrenia.Conclusion CAR and NAR are reliable biomarkers of inflammation and a combination of inflammatory markers including CAR and NAR could be used to reflect the increased inflammatory status in schizophrenia, regardless of relapse or remission.

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“…In addition, we found that patients with RLS showed lower serum protein level than the rest of IDA women, which is according to a recent study reporting lower serum albumin levels in RLS patients than in a control group. 39 A considerable body of evidence has established that appropriate levels of brain iron are necessary for optimal brain development and functioning. 40 Nonetheless, despite the high prevalence of ID in women of reproductive age, relatively few studies [41][42][43][44][45] have examined the relationship between iron status and cognition in this group, focusing instead on infants and children.…”

Section: Discussionmentioning

confidence: 99%

Iron Deficiency in Menstruating Adult Women: Much More than Anemia

Fernández-Jiménez

Moreno

Wright

et al. 2020

Women's Health Reports

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Background: Iron deficiency anemia (IDA) is highly prevalent in women of child-bearing age. However, their nonhematological symptoms have been overlooked. This study aims to analyze the nonhematological features and symptoms of IDA in a group of women of reproductive age and the changes occurred during iron therapy. Materials and Methods: IDA women underwent dietary, physical activity, menstrual blood loss, and cognitive function assessment at baseline. Hematological and biochemical parameters were analyzed. Executive attention was tested by the flanker task and working memory by the 2-back task. Oral iron therapy (ferrous sulfate) was given to 35 women for 8 weeks and the changes in iron status, biochemical markers, cognitive function, and nonhematological symptoms were evaluated. Results: Patients presented nonhematological symptoms: pica, 32.4%; cheilitis, 20.6%; restless legs syndrome (RLS), 20.6%; diffuse hair loss, 55.9%; and ungual alterations, 38.2%. Two or more symptoms were present in 58.8% of women. Serum iron and working memory were correlated at baseline. Multivariate analyses show associations (odds ratio [OR], 95% confidence interval [CI]) between pica and reaction time in the working memory test (OR 2.14, 95% CI 1.19-3.87, p = 0.012); RLS with total serum protein (OR 0.08, 95% CI 0.06-0.92, p = 0.043); and cheilitis with mean corpuscular hemoglobin (OR 0.388, 95% CI 0.189-0.799, p = 0.01). Pica, cheilitis, and RLS completely resolved with iron therapy, and ungual alterations and hair loss improved in 92.3% and 84.2% of women, respectively. Better performance in executive attention and working memory was observed after iron therapy. Conclusions: More attention should be given to the nonhematological manifestations of IDA to improve the quality of life of menstruating women.

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Serum C-reactive protein/albumin ratio and restless legs syndrome

Cited by 28 publications

References 37 publications

The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis—A Questionnaire-Based Cross-Sectional Analysis

The Assessment of Risk and Predictors of Sleep Disorders in Patients with Psoriasis—A Questionnaire-Based Cross-Sectional Analysis

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

Iron Deficiency in Menstruating Adult Women: Much More than Anemia

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