“…ET‐1 expression correlates with a poor prognosis in lung cancer (Boldrini et al., ). In HNSCC, several studies have identified the ET system as potential biomarkers of HNSCC progression and prognosis (Alaizari, Abdelbary, & Amin, ; Cheng et al., ; Hinsley, Hunt, Hunter, Whawell, & Lambert, 2012a; Hinsley, Kumar, Hunter, Whawell, & Lambert, 2012b; Hoffmann, Yurgel, & Campos, , ; Mankapure, Barpande, Bhavthankar, & Mandale, ). It has been demonstrated that overexpression of ET axis components has been found in HNSCC, ET‐1 can promote progression or invasion by stromal–epithelial interactions, and targeting the stromal ET system may be a novel therapeutic strategy (Hinsley et al., 2012b; McKenzie, Hinsley, Hunter, & Lambert, ).…”