Serum apelin levels and metabolic risk markers in obese women

Zaki, Moushira Erfan; Kamal, Sanaa; Ezzat, Wafaa M.; Hassan, Nayera E.; Yousef, Walaa; Ryad, Hanaa; Mohamed, Ramy; Youness, Eman R.; Basha, Walaa A.; Elhosary, Yasser A.

doi:10.1016/j.jgeb.2017.05.002

Cited by 17 publications

(10 citation statements)

References 30 publications

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“…Several studies have demonstrated a potential link of apelin with obesity. In obese women the level of serum apelin was significantly increased in comparison to healthy controls and was positively correlated with abnormal metabolic parameters (30). The same result was observed in children, where serum level of apelin was higher in obese patients than in the control group (31).…”

Section: Discussionsupporting

confidence: 66%

The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells

Podgórska

Pietraszek-Gremplewicz

Olszańska

et al. 2021

Anticancer Res

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Background/Aim: Colon cancer is the second deadliest malignancy for human. Its correlation with obesity has led to an increasing number of studies focusing on the role of adipokines in colon cancer development. Apelin, which belongs to the family of adipokines, affects several pathological processes, including heart diseases, obesity and carcinogenesis. In this study, we examined the importance of apelin and apelin receptor (APJ) during motility regulation of colon cancer cells. Materials and Methods: Colon cancer cells with overexpression of apelin receptor, as well as cells with down-regulation of apelin were used in this study. Migration and invasion ability was tested using Transwell ® filters. The proteolytic activity was analyzed with fluorescentsubstrate degradation assay and gelatin zymography. We also used confocal microscopy to examine migratory protrusion formation and the localization of MT1-MMP. The levels of AKT and ERK kinases were evaluated using Western blotting assay. Results: Overexpression of APJ receptor resulted in increased migration and invasion abilities through stimulation of migratory protrusion formation and proteolytic activity. These processes were mediated by PI3K/AKT and MAPK signaling pathways. Opposite effect was obtained when the level of apelin was down-regulated. Conclusion: The level of apelin and its receptor is strictly connected with regulation of migration and invasion of colon cancer cells. Therefore, apelinergic system seems to be a promising target for anti-cancer therapy.Colorectal cancer (CRC) is the second deadliest malignancy for all the human population. The lifetime risk of developing CRC is about 1 in 23 for men and 1 in 25 women, while it has been shown that it is strongly associated with environmental and lifestyle factors, such as diet, tobacco, alcohol, androgen deprivation therapy, and obesity (1). A meta-analysis showed that elevated body mass index (BMI) is positively correlated with CRC development. There are several evidences for this association including changes in insulin-like growth factor 1 signaling, sex hormones, systemic inflammation and altered expression of adipokines (2).Adipose tissue not only regulates energy homeostasis, but is also a part of endocrine system secreting adipokines, growth factors, cytokines and chemokines. Adipokines are essential mediators of various metabolic processes, such as gluconeogenesis, glucose uptake, insulin signaling and fatty acid oxidation. During the development of obesity, the excess of adipose tissue results in increased adipokines secretion, that lead to protection against some of the adverse metabolic consequences of obesity (3). However, several studies have shown that increased level of adipokines, such as apelin, could be connected with higher probability to develop cancer, including gastroesophageal cell carcinoma (4), gastric cancer (5), non-small cell lung carcinoma (6), bladder cancer (7), prostate cancer (8), ovarian cancer (9), and breast cancer (10).The apelin-encoding gene (APLN) is located on...

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Section: Discussionsupporting

confidence: 66%

The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells

Podgórska

Pietraszek-Gremplewicz

Olszańska

et al. 2021

Anticancer Res

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“…However, some data reported in literature show that APLN level is increased in obese patients suggesting that BMI is positively correlated with APLN levels [120,121]. Moreover, some authors have suggested that in obese patients APLN expression is elevated in white adipose tissue and decreased in brown adipose tissue.…”

Section: Apelin/apj Axis: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…При дослідженні молодих пацієнтів з ожирінням рівень апеліну в плазмі був зниженим в порівнянні зі здоровими пацієнтами, що можна певною мірою пояснити ймовірним виснаженням його компенсаторних можливостей та розвитком і тяжкістю інсулінорезистентності при ожирінні. Проте, інше дослідження показало, що рівень апеліну в плазмі був значно вищим у дітей з ожирінням порівняно з дітьми без ожиріння та надлишкової маси тіла [2,22,24]. За даними деяких авторів, апелін вважається діагностичним маркером прогнозування розвитку неалкогольної жирової хвороби печінки і позитивно корелює з окружністю талії і холестерином ліпопротеїдів низької щільності [12].…”

Section: вступunclassified

“…BO = -0,875 моделі). Окрім того, такий результат можна пояснити компенсаторними можливостями апеліну, що знаходить підтвердження в деяких дослідженнях [1,2,22,24].…”

Section: обговоренняunclassified

Clinical and instrumental profile of patients with stage II essential hypertension with different forms of extrasystoles according to the level of apelin-13

Іvankova¹,

Kuzmіnova²,

Іванов³

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Essential hypertension (EH) is one of the leading causes of disability and mortality among cardiovascular diseases, so today new metabolic markers of cardiovascular risk are being actively studied. One of them is apelin-13. Objective – to evaluate the clinical and instrumental profile of patients with stage II hypertension with different forms of extrasystoles and different neurohumoral background – conditionally high/low serum apelin-13 levels. 156 patients with stage II essential hypertension were examined. 124 of them had frequent symptomatic extrasystoles, 32 patients had no arrhythmias and were considered to the comparison group. 30 practically healthy normotensive persons were considered to the control group. All patients underwent a complete clinical and anthropometric examination, blood pressure measurement, automatic daily blood pressure monitoring, daily electrocardiogram monitoring, echocardiography and the assessment of serum apelin-13 level. For statistical analysis, the procedure of non-linear data estimation was chosen, namely logistic regression or logit model. To form the basic statistical matrix of the analysis, we used clinical-instrumental and laboratory indicators, which passed a preliminary correlation analysis of Spearman with the level of apelin-13 serum and found a significant correlation (p<0.05). In the course of the logistic analysis at the final model, which allowed to predict “background of apelin” in patients with stage II EH entered 4 independent factors that revealed statistically significant (p<0.05) correlations with the initial parameter: the value of the systolic arterial pressure time index in%, the index of the left atrium in mm/m2, the average number of ventricular extrasystoles for 1 hour and the level of total cholesterol in plasma in mmol/l. The last indicator showed the least informativeness in predicting of the apelin-13 serum level. Interpreting the data of the obtained logit regression model, it should be said that in patients with EH of increasing the value of the systolic arterial pressure time index, the index of the left atrium and the average value of ventricular extrasystoles during 1 hour and decrease total cholesterol level in plasma increase the probability of determining relatively low (<920 pg/ml) and at the same time reduce the probability of determining a relatively high (≥920 pg/ml) level of apelin serum. These data also show that the highest informativeness in predicting the level of apelin-13 in patients with EH was the total number of ventricular extrasystole per hour. So, a high “apelin background” (≥920 pg/ml) in patients with EH will be accompanied by a benign course of the disease, so an increase serum apelin-13 in patients with EH should be considered as positive neurohumoral changes that promote cardioprotection, improve prognosis course of the disease and reduce cardiovascular risk.

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Serum apelin levels and metabolic risk markers in obese women

Cited by 17 publications

References 30 publications

The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells

The Role of Apelin and Apelin Receptor Expression in Migration and Invasiveness of Colon Cancer Cells

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Clinical and instrumental profile of patients with stage II essential hypertension with different forms of extrasystoles according to the level of apelin-13

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