2017
DOI: 10.1002/jcla.22276
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Abstract: Despite the limiting factors, anti-PGL1 IgA correlates to IgM levels and it could be considered as a possible laboratorial tool to be also used, for instance, in serological follow-up studies.

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Cited by 5 publications
(5 citation statements)
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References 32 publications
(44 reference statements)
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“…Their results demonstrated better performance of IgA than IgG isotype by comparing the correlation of both with IgM responses. In this context, serum IgG presented low diagnostic sensitivity even in MB patients while diagnosis sensitivity based upon IgA was higher, but still far from that of serum IgM in MB patients (19).…”
Section: Discussionmentioning
confidence: 80%
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“…Their results demonstrated better performance of IgA than IgG isotype by comparing the correlation of both with IgM responses. In this context, serum IgG presented low diagnostic sensitivity even in MB patients while diagnosis sensitivity based upon IgA was higher, but still far from that of serum IgM in MB patients (19).…”
Section: Discussionmentioning
confidence: 80%
“…Interestingly, our experiments show that the IgA responses did not rely on the nature of the antigen, because all the evaluated antigens led to increased IgA reactivity. In that sense, it has already been demonstrated that IgA reactivity to PGL-I correlates with IgM responses in both serum and saliva (19,28). As the nasal mucosal surfaces are the main portal of entrance for M. leprae (18), the antigen challenge induces local humoral antibody responses, mainly IgA, which appears early in saliva than in serum (18).…”
Section: Discussionmentioning
confidence: 97%
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“…IgA is an antibody associated with the mucosal response, the main gateway of the bacillus in the establishment of infection, participating in the early stages of HD and in subclinical infection ( 19 – 21 ). The importance of IgA for host mucosal immunity is well established and, although its role in the systemic circulation has not been fully elucidated ( 22 ), its usefulness as an immunological marker in laboratory tests has been confirmed.…”
Section: Discussionmentioning
confidence: 99%