Serum Anti-Müllerian hormone in polycystic ovary syndrome and its relationship with insulin resistance, lipid profile and adiponectin

Abstract

Objectives: This study was done to estimate serum anti-Müllerian hormone (AMH) level in polycystic ovary syndrome (PCOS) patients and to correlate serum AMH level with insulin resistance, lipid profile, and adiponectin levels. Materials and Methods: A cross-sectional study was conducted at Hospital Universiti Sains Malaysia (Hospital USM), Health Campus, Kubang Kerian, Kelantan, Malaysia. Thirty newly diagnosed patients with PCOS attending gynecology clinic between July 2016 and April 2017 were recruited. Fasting venous blood samples were collected from the subjects. Serum AMH, insulin, adiponectin, triglycerides, high-density lipoprotein cholesterol (HDL-C), and plasma glucose levels were measured, and insulin resistance was calculated based on homeostasis model of assessment-insulin resistance (HOMA-IR). The serum AMH level was estimated, and the correlation of serum AMH level with the metabolic parameters was analyzed. Results: The median of serum AMH levels in women with PCOS was 6.8 ng/mL (interquartile range: 7.38 ng/mL). There was a significant negative correlation between serum AMH and HOMA-IR or triglyceride levels ( r = −0.49, P = 0.006 and r = −0.55, P = 0.002, respectively). A significant positive correlation was observed between serum AMH and serum HDL-C or serum adiponectin levels ( r = 0.56, P = 0.001 and r = 0.44, P = 0.014, respectively) in all study subjects. Conclusion: The serum AMH level is associated with HOMA-IR, triglycerides, HDL-C, and adiponectin levels, and hence it may be used as a potential cardiometabolic risk marker in women with PCOS.

Age‐group‐specific reference intervals for anti‐Müllerian hormone and its diagnostic performance for polycystic ovary syndrome in a Korean population

“… 26 , 27 A significant negative correlation between serum AMH and insulin resistance had been observed in PCOS women. 28 , 29 Abdolhian et al 30 showed that an exercise intervention can significantly decrease AMH levels. AMH levels in PCOS cases could be regulated by a complicated mechanism, because PCOS is a complex reproductive and hormonal disorder that can derange metabolic parameters.…”

The Relationship of Anti-Mullerian Hormone in Polycystic Ovary Syndrome Patients with Different Subgroups

“…A previous study demonstrated that there was a significant negative correlation between AMH level and homeostasis model assessment of insulin resistance (HOMA-IR) or triglyceride levels, and a positive correlation between AMH and high-density lipoprotein cholesterol (HDL-C) or serum adiponectin level, so that AMH is also a potential cardiometabolic risk marker in women with PCOS. 28 Although the correlation between AMH and BMI remains unclear, the associations between AMH and metabolic syndrome were modified by BMI; hence, the women who had PCOS with normal BMI did not have an increased risk of metabolic syndrome. 29 The present study is a retrospective study, and owing to the mobility of outpatients and incomplete data, metabolic markers were not included in the clinical data and the corresponding causal analysis data could not be obtained from this study; we will confirm these data in subsequent experiments.…”

<p>Correlation Between Recovery of Menstrual Cycle and Improvement of Glucose and Lipid Metabolism in Patients with Sleeve Gastrectomy in a Small Chinese Cohort Sample</p>

“…The concentration of androgen can regulate menstrual cycle, but ovulation cannot be restored during treatment. 8 At the same time, once the drug is stopped, menstrual disorder will return, with no long-term treatment effect. Metformin, which can improve insulin resistance, has been proved to be an adjuvant therapy for ovulation induction and androgen reduction, but cannot completely regulate the menstrual cycle.…”