Serum and urine zinc response in head-injured patients

McClain, Craig J.; Twyman, Diana; Ott, Linda; Rapp, Robert P.; Tibbs, Phillip A.; Norton, Jane A.; Kasarskis, Edward J.; Dempsey, Robert J.; Young, Byron

doi:10.3171/jns.1986.64.2.0224

Cited by 94 publications

(43 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Post-traumatic tissue needs a large number of zinc to participate in, which results in the redistribution and the decrease of zinc in vivo. At the same time, urinary zinc excretion in injured group increases obviously [21]. The decrease of zinc concentrations in serum was the result of SCI and in turn Zinc is a small hydrophilic charged species, which cannot cross biological membranes by passive diffusion.…”

Section: Discussionmentioning

confidence: 95%

The Correlation Among the Dynamic Change of Zn2+, ZnT-1, and Brain-Derived Neurotrophic Factor After Acute Spinal Cord Injury in Rats

Wang

Mei

Zhang

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

Zinc plays an important role in regulating the expression of brain-derived neurotrophic factor (BDNF) and its receptor in nervous system, but the correlation among Zn(2+), zinc transporter, and BDNF in spinal cord injuries (SCI) is not fully understood. The purpose of this study was to investigate the expression of Zn(2+), zinc transporter 1 (ZnT-1), and BDNF, as well as their correlation in spinal cord-injured rats. One hundred Wistar male rats were divided into two groups: sham-operated group (as control group) and model group. Spinal cord injury was induced in model groups by hemisection of T9 on the left side. Compared with the control group, the serum zinc levels in SCI model group were significantly decreased after surgery, but zinc concentrations in spinal cord were increased gradually. The mRNA levels of ZnT-1 and BDNF were significantly increased in SCI model group, and there is a positive correlation between them (Spearman rho = 0.381, P = 0.0204). The correlation found between BDNF and ZnT-1 allows us to speculate that these two factors may be physiologically co-regulated, which may provide an idea for the treatment of SCI.

show abstract

Section: Discussionmentioning

confidence: 95%

The Correlation Among the Dynamic Change of Zn2+, ZnT-1, and Brain-Derived Neurotrophic Factor After Acute Spinal Cord Injury in Rats

Wang

Mei

Zhang

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…In patients with a brain injury, there are clear acute increases in urinary zinc excretion and significant decreases in serum zinc levels that have been shown to be proportional to the severity of injury [3]. A recently published article provides insight into the mechanisms responsible for this observation.…”

Section: Traumatic Brain Injury and The Development Of Zinc Deficiencymentioning

confidence: 96%

Zinc in traumatic brain injury

Morris

Levenson²

2013

Current Opinion in Clinical Nutrition and Metabolic Care

View full text Add to dashboard Cite

show abstract

“…O comportamento da proteína-C-reativa passa a ser mais um argumento a favor de que as repercussões metabólicas e inflamatórias do TCE não persistem além de duas semanas após lesão do tecido encefálico. McClain e col. 22 , apresentaram resultados comparáveis, com pico no 4° dia e queda entre o 13° e o 16° dias.…”

Section: Proteínas De Fase Aguda E Evolução Clínica Dos Pacientesunclassified

A resposta metabólica ao trauma cranioencefálico é autolimitada? Análise das proteínas de fase aguda e glicemia

Schelp

Angeleli

Zanini

et al. 1998

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

RESUMO -Nos últimos anos tem havido referências à limitação da resposta metabólica nas duas primeiras semanas após trauma cranioencefálico (TCE). Foi feita proposta de estudo a partir de experimento clínico em pacientes com trauma encefálico grave, que foram avaliados por volta de 7 dias após a lesão (M1). A segunda avaliação ocorreu 4 dias após (M2), e a terceira 3 a 4 dias após (M3). Em um período de 2 anos, foram selecionados 28 pacientes do sexo masculino, com trauma encefálico grave, escala de gravidade de Glasgow entre 4 e 6. Dentre os 28 pacientes, 6 completaram o estudo proposto. Os pacientes foram acompanhados clinicamente durante toda a fase do experimento. Em cada um dos momentos de análise, foram feitas análises da excreção nitrogenada e proteínas de fase aguda. Da mesma forma foram feitas determinações da glicemia plasmática, N-amínico e triglicerídeos. Os resultados do estudo demonstraram não haver modificações no balanço nitrogenado, normalização da proteína-C-reativa e redução relativa da glicemia ao final do experimento. Os autores tecem considerações sobre os possíveis mecanismos envolvidos na modulação da resposta metabólica e concluem que o hipermetabolismo, a basear-se na análise da glicemia e das proteínas de fase aguda, não persiste além do 13°d ia do período de recuperação pós-trauma. São feitas sugestões de estudos futuros que possam elucidar os mecanismos envolvidos na normalização do hipercatabolismo e hipermetabolismo observados nas duas primeiras semanas após TCE. PALAVRAS-CHAVE: trauma cranioencefálico, proteínas de fase aguda, metabolismo protéico. Is the metabolic response self-limited in head trauma? Analysis of acute phase proteins and glycemiaABSTRACT -There are many reports supporting a self-limitation mechanism involved with hypermetabolic response after severe cranial injury. It was proposed a study with severe head injury patients, in three stages of the evolution. The first 7 days after admission (moment 1-M1), the second three days latter (M2) and the last 7 days after the first (M3). Among male patients with severe head injury, attended between January 1992 and December 1993 in University Hospital of Botucatu, UNESP, were selected 28 male patients, with Glasgow severity scale between 4 and 6, with pO 2 < 70 mm Hg, weighting 60 kg or more. Among these patients, 6 finished the study, including analysis of the excretion of N, acute phase proteins, glycemia, triglycerides and amine nitrogen. During the study there were no changes in nitrogen balance and there was a decrease in protein Creative. Glycemia tends to fall within two weeks after injury. The authors make some considerations about possible mechanisms involved in brain modulation associated with the period of dependence of hypermetabolism and hypercatabolism after closed brain injury. There are some evidences that the brain responds to head trauma with a gobal non specific way, which tends to be reorganized beyond the first two weeks after lesion. The study does not show any influence of the type and severity of head...

show abstract

Serum and urine zinc response in head-injured patients

Cited by 94 publications

References 52 publications

The Correlation Among the Dynamic Change of Zn2+, ZnT-1, and Brain-Derived Neurotrophic Factor After Acute Spinal Cord Injury in Rats

The Correlation Among the Dynamic Change of Zn2+, ZnT-1, and Brain-Derived Neurotrophic Factor After Acute Spinal Cord Injury in Rats

Zinc in traumatic brain injury

A resposta metabólica ao trauma cranioencefálico é autolimitada? Análise das proteínas de fase aguda e glicemia

Contact Info

Product

Resources

About