Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease

Horgan, Stephen; Watson, Chris; Glezeva, Nadezhda; Collier, Pat; Neary, Roisín; Tea, Isaac; Corrigan, Niamh; Ledwidge, Mark; McDonald, Ken; Baugh, John

doi:10.1007/s12265-015-9661-1

Cited by 9 publications

(9 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SAP interacts with complement factors 37 and inhibits the recruitment of profibrotic macrophages. 38 In addition, it protects from cell damage induced by histone H3, 39 a potential mechanism contributing to photoreceptor cell death. 40 …”

Section: Discussionmentioning

confidence: 99%

Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study

Kowalczuk

Matet

Dor

et al. 2018

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

PurposeTo investigate the molecular composition of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) and rhegmatogenous retinal detachment (RRD) using proteomics and metabolomics.MethodsSRF was obtained from one patient with severe nonresolving bullous CSCR requiring surgical subretinal fibrin removal, and two patients with long-standing RRD. Proteins were trypsin-digested, labeled with Tandem-Mass-Tag and fractionated according to their isoelectric point for identification and quantification by tandem mass spectrometry. Independently, metabolites were extracted on cold methanol/ethanol, and identified by untargeted ultra-high performance liquid chromatography and high-resolution mass spectrometry. Bioinformatics analyses were conducted.ResultsIn total, 291 proteins and 651 metabolites were identified in SRF samples. Compared with RRD, 128 proteins (77 downregulated; 51 upregulated) and 76 metabolites (43 downregulated; 33 upregulated) differed in the SRF from CSCR. Protein and metabolites notably deregulated in CSCR were related to glycolysis/gluconeogenesis, inflammation (including serum amyloid P component, versican), alternative complement pathway (complement factor H and complement factor H–related protein), cellular adhesion, biliary acid metabolism (farnesoid X receptor/retinoid X receptor), and gluco- and mineralocorticoid systems (aldosterone, angiotensin, and corticosteroid-binding globulin).ConclusionsProteomics and metabolomics can be performed on SRF. A unique SRF sample from CSCR exhibited a distinct molecular profile compared with RRD.Translational RelevanceThis first comparative multiomics analysis of SRF improved the understanding of CSCR and RRD pathophysiology. It identified pathways potentially involved in the better photoreceptor preservation in CSCR, suggesting neuroprotective targets that will require additional confirmation.

show abstract

Section: Discussionmentioning

confidence: 99%

Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study

Kowalczuk

Matet

Dor

et al. 2018

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

show abstract

“…Thus, PTX3 and CRP were suggested to be associated with atherosclerotic lesions 20 . Serum amyloid A (SAA) was suggested to enhance the local effect and to be a more valuable biomolecular diagnosis for acute myocardial infarctions than the other APR 18 .…”

Section: Introductionmentioning

confidence: 99%

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Temelli

Savaş

et al. 2018

J. Appl. Oral Sci.

View full text Add to dashboard Cite

ObjectivesOne of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients.Material and MethodsPatients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included. Clinical periodontal parameters (probing depth - PD, clinical attachment loss, and bleeding on probing - BOP) were previously recorded and participants were divided into four groups after coronary angiography: Group 1: CAD (+) with periodontitis (n=20); Group 2: CAD (+) without periodontitis (n=20); Group 3: CAD (-) with periodontitis (n=21); Group 4: CAD (-) without periodontitis (n = 16). Serum interleukin (IL) −1, −6, −10, tumor necrosis factor (TNF)-α, serum amyloid A (SAA), pentraxin (PTX) 3, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with ELISA.ResultsGroups 1 and 3 showed periodontal parameter values higher than Groups 2 and 4 (p<0.0125). None of the investigated serum parameters were statistically significantly different between the study groups (p>0.0125). In CAD (-) groups (Groups 3 and 4), PISA has shown positive correlations with PTX3 and SAA (p<0.05). Age was found to predict CAD significantly according to the results of the multivariate regression analysis (Odds Ratio: 1.17; 95% Confidence Interval: 1.08-1.27; p<0.001).ConclusionsAlthough age was found to predict CAD significantly, the positive correlations between PISA and APR in CAD (-) groups deserve further attention, which might depend on the higher PISA values of periodontitis patients. In further studies conducted in a larger population, the stratification of age groups would provide us more accurate results.

show abstract

“…Both acute phase proteins have not been previously studied in response to ACE.Alpha-2-macroglobulin is a protein involved in humoral defense, and has been investigated as a marker for CVD, but data are conflicting [25,27]. Elevated serum amyloid P in blood is associated with increased angina and myocardial infarction and may play a role in cardiac remodeling [26,31]. In summary, acute phase proteins remained unchanged or returned to pre-ACE values 2 h post-ACE.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, changes in expression of acute phase proteins can be used to assess tissue damage after a CVD event or physiological stress. Chronic inflammation and CVD disease risk has been associated with alteration in the production of particular acute phase proteins including C-reactive protein, ferritin, fibrinogen, procalcitonin, serum amyloid A, serum amyloid P, tissue plasminogen, α-2-macroglobin, and haptoglobin [3,19,[23][24][25][26][27][28][29][30][31]. Therefore, to fill the gap in the relevant literature, the present study aimed to examine the effects of ACE on a comprehensive panel of plasma inflammatory, lipid biomarkers and acute phase proteins related to CVD risk.…”

Section: Introductionmentioning

confidence: 99%

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Sesatty¹,

Fogt²,

Chung³

et al. 2019

Long-Term Survival of Patients With Ischemic Cardiomyopathy and Diabetes as Compared to Those Without Diabetes Undergoing Myoca

View full text Add to dashboard Cite

Acute cold exposure (ACE) stimulates metabolism but data evaluating inflammatory and lipid biomarkers related to cardiovascular disease in response to ACE are lacking. Therefore, we investigated the relationship between ACE and inflammatory and lipid biomarkers. Methods: Twenty subjects underwent 30 min of ACE with blood drawn: 1) pre-ACE (baseline), 2) at 30 min ACE, and 3) 2 h post-ACE. Plasma was analyzed for 10 cytokines (monocyte chemoattractant protein-1 (CCL2), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-α), interferon-gamma (INFγ)), 9 acute phase proteins (ferritin, fibrinogen, procalcitonin, serum amyloid A, serum amyloid P, tissue plasminogen, C-reactive protein, haptoglobin, α-2-macroglobin), and 5 lipid biomarkers (triglycerides, nonesterified fatty acids (NEFA), low-and high-density lipoprotein (LDL, HDL), and total cholesterol). Heart rate, whole body oxygen consumption (VO2), energy expenditure (EE), shivering sensations, and pain were measured prior and during ACE. Results: ACE increased heart rate by 11%, shivering sensations by 4-fold, pain by 2-fold, VO2 by 50%, and EE by 52%. IL-1β increased after 30 min ACE by 24% (p=0.048) and 2 h post ACE by 65% (p=0.01). Alpha-2-macroglobin increased after 30 min ACE by 16% (p=0.005) and returned to baseline levels 2 h post-ACE. HDL increased at 2 h post-ACE by 15% (p=0.034). Sex differences were noted between IL-2, IL-6, IL-8, ferritin, α-2-macroglobin and HDL. Conclusions: These findings indicate ACE increases EE and modifies inflammation, the acute phase response, and lipid metabolism.

show abstract

Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease

Cited by 9 publications

References 58 publications

Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study

Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study

Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Contact Info

Product

Resources

About