Serum Amyloid a Protein in Patients with Acute Myocardial Infarction

Abstract

(J Zagreb, Croatia SUMMARY. The concentrations of four acute phase proteins were measured in sera of 40 patients with acute myocardial infarction (AMI) to evaluate their behaviour from day-to-day and to find out if they can serve for early prediction of postinfarction complications and mortality rate. Peak levels of serum amyloid A protein (SAA) were increased up to 5000-fold above the normal value and those of C-reactive protein (CRP) about loo-fold, 3 days after AMI. 0/ l-antichymotrypsin (ACT) and 0/ l-acid glycoprotein (AGP) peak levels were increased up to eightfold above their normal values. Patients who developed postinfarction complications had significantly higher SAA values on admission than those without complications (mean values of 379 and 45mg/L, respectively; P<O·OOOI). Using a level of loomg/L on admission as a reference value gave a reasonable sensitivity and predictive value for complications (730/0) and a very good sensitivity (80%) for early prediction of fatal outcome. Patients with SAA values above this limit had double the risk of complications and four times the risk of a fatal outcome. The correlation with CRP values was lower than it was with SAA values (P = O'028) using a level of 15 mg/L on admission as reference value gave low sensitivity (55%) and predictive value (60%) for complications as well as low sensitivity for early prediction of fatal outcome (60%). The present study did not allow prediction of complications or mortality based on ACT or AGP values.

Serum Amyloid A Protein in the Prediction of Postburn Complications and Fatal Outcome in Patients with Severe Burns

“…arAntichymotrypsin and αϊ-acid glycoprotein peak levels were increased up to sixfold above their normal values. These findings are very similar to our previous observations with acute phase proteins in patients with acute myocardial infarction (8). On admission to hospital, the ratio between serum amyloid A protein and C-reactive protein levels was usually between 5 : 1 and 11:1, which is similar to those observed during kidney allograft rejection (10 : 1) (17-19), influenza (11:1) or pneumonia (7:1) (9).…”

“…Although some 34 known plasma proteins increase in concentration during inflammation, only two of them are suitable markers of acute phase response: serum amyloid A protein and Creactive protein (4-6). Both are quick to respond and both increase substantially in severe inflammation, but serum amyloid A protein is the more sensitive quantity (6)(7)(8)(9). It shows a more than 1000-fold increase in plasma concentration a few hours (4-6) after inflammatory stimulus (3), and has a very short half life of between 75 and 90 minutes (10,11).…”

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm1

“…inflammatory diseases and cancer [7]. Evidence has emerged indicating that increased serum level of MMP-8 is a risk for cardiovascular diseases [15,21], and it has been shown to be positively correlated with the worst cardiovascular outcome, namely death from cardiovascular causes [15] and also with acute phase proteins, e.g., CRP [22,23].…”

Current Status of Problem of Early Diagnosis of Ovarian Cancer and Its Solutions (Literature Review)

“…Концентрация A-SAA в крови при воспалении повышается до 1 мг / мл и более при норме 1-10 мкг / мл [39]. Известно, что концентрация A-SAA повышается при инфекционных заболеваниях бактериальной и ви-русной природы (Nakayama et al, 1993), остром пан-креатите [11], инфаркте миокарда [40], после ожогов [41]. В большинстве случаев повышенный уровень SAA коррелирует с тяжестью протекания и неблаго-приятным исходом заболевания [40][41][42].…”