Serum Albumin and Natural Products

Application of electronic circular dichroism in configurational and conformational analysis of organic compounds

“…Albumin has strong absorptions, associated to CD only below 300 nm, therefore complexation of achiral guests endowed with red-shifted chromophores can be very efficiently analysed by studying their ICD. 31,42 Carotenoids can be hosted in the manifold of binding sites usually occupied by fatty acids. The observed ICD for crocetin-human serum albumin complex shows a typical negative couplet with crossover around 420 nm, i.e.…”

Rheological Behavior of Plasma Polymerized Iodine-Doped Polypyrrole Particles Suspended in Solutions of Bovine Serum Albumin.

“…The protein serum albumin (SA) is a biomolecule of biotechnological interest due to its biological properties and its involvement in the transportation of nutrients and drugs, physiological regulation of pH and osmotic pressure, ability to act as a chelating agent (Di Bari et al, 2004;Peters Jr, 1995) and for its neuroprotective effect (Diaz-Ruiz et al, 2010;Gum et al, 2004), among other uses. Some of these properties have been exploited, mainly in the pharmaceutical and food sector, to obtain systems that are made of ordered multiphase structures, (Peters Jr, 1995) such as latex particles coated with polypyrrole (PPy) (Bousalem et al, 2004), which can be used as a drug delivery vehicle in a suspension of particles of PPy-alginate (Thanpitcha et al, 2011) or as a coating in metal stents and bars (Khan et al, 2007), as an example of some applications.…”

Interactions between quercetin and Warfarin for albumin binding: A new eye on food/drug interference

“…Serum albumin is a carrier protein because it plays a central role in the transportation and deposition of many endogenous and exogenous ligands present in the blood 1. Many research activities have been performed recently, which prove the involvement of albumin in making flavonoids bioavailable in animals and notably in man 2–10…”