Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers

Chiang, Chien-Hsieh; Lai, Jin-Shin; Hung, Shou-Hung; Lee, Long‐Teng; Sheu, Jin‐Chuan; Huang, Kuo‐Chin

doi:10.1002/oby.20000

Cited by 31 publications

(36 citation statements)

References 30 publications

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“…The participants’ average age ranged 33–61 years. Ten studies [36–41, 44–47] only reported MetS components in the form of continuous variables, and they mainly affected the pooled SMD of MetS components. Consequently, we did not consider in our analysis the MetS criteria they used.…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, we did not consider in our analysis the MetS criteria they used. In other words, whether these studies [36–41, 44–47] meet the MetS criteria (Q4: The MetS and its components were defined accurately) did not affect the statistical results (SMD), so they were labeled with “UR” (unrelated) for Q4 in Table 3. The remaining 20 studies [10–17, 26–35, 42, 43] reported ORs or crude data for calculating the ORs.…”

Section: Resultsmentioning

confidence: 99%

“…The last 10 studies [36–41, 44–47] in the table reported only metabolic syndrome (MetS) components in the form of continuous variables, and they mainly affected the pooled standardized mean difference (SMD) of the MetS components. SMD was not related to the diagnostic criteria of MetS.…”

Section: Resultsmentioning

confidence: 99%

“…SMD was not related to the diagnostic criteria of MetS. Whether these studies [36–41, 44–47] meet Q4 (Q4: MetS and its components were defined accurately) did not affect the statistical results (SMD), so they were labeled “UR” for Q4. The first 20 studies in the table reported OR or crude data for calculating the OR, and the MetS criteria they used affected the statistical results (pooled ORs) directly.…”

Section: Resultsmentioning

confidence: 99%

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Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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Background and aimAs there is conflicting evidence for the relationship between hepatitis B virus surface antigen (HBsAg) positivity and the prevalence of metabolic syndrome (MetS), we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS.MethodsObservational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios (ORs) of MetS and its components (central obesity, increased fasting glucose, increased blood pressure, dyslipidemia) for subjects with or without HBsAg positivity were synthesized. The standardized mean difference of MetS components between HBsAg-positive participants and healthy controls was calculated. Heterogeneity was explored with subgroup analysis and sensitivity analysis. Publication bias was detected using Egger’s test and Begg’s test.ResultsThirty studies were eligible for meta-analysis. The MetS OR for HBsAg-positive participants was significantly decreased compared with the controls [OR = 0.80, 95% confidence interval (CI), 0.70–0.90]. The negative effect of HBsAg positivity on elevated triglycerides (OR = 0.62, 95% CI, 0.59–0.64) was strong, while that for increased fasting blood glucose was weak (OR = 0.94, 95% CI, 0.90–0.98). The pooled ORs of central obesity (OR = 0.97, 95% CI, 0.91–1.04), reduced high-density lipoprotein cholesterol (OR = 0.98, 95% CI, 0.83–1.14), and elevated blood pressure (OR = 1.00, 95% CI, 0.80–1.25) for HBsAg-positive participants were all not significantly different compared with the controls. No publication bias was detected.ConclusionsSerum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Li¹,

Zhao²,

Wu³

2017

PLoS ONE

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“…3,4 ACKNOWLEDGEMENT The authors' declarations of personal and financial interests are unchanged from those in the original article. …”

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confidence: 99%

Editorial: metabolic syndrome delays HBeAg seroclearance in Chinese patients with hepatitis B – authors' reply

Hsiang

Wong

Chan

et al. 2014

Aliment Pharmacol Ther

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They pointed out the relevance of the interaction between metabolic syndrome and chronic hepatitis B (CHB), given the prevalence of the two diseases and the confounding effect of the age of patients.Our study of 413 hepatitis B e antigen (HBeAg)-positive, treatment-na€ ıve patients were split into three groups of varying metabolic risks.2 The patients with metabolic risk factors (pre-MetS and MetS groups), despite being older compared with the normal group, had comparable baseline viral load, alanine aminotransferase level and genotype distribution which are all critical factors associated with delayed HBeAg seroconversion. To tackle the confounding effect of age, we chose age at HBeAg seroclearance as the time variable in the Cox regression analysis. This would avoid any younger patients entering the study with a longer follow-up without HBeAg seroclearance being censored and an older patient with HBeAg seroclearance within a short follow-up. We agree with the need to control key variables such as age and gender to tease out the specific interaction between obesity-related features and chronic hepatitis B. This would involve an age and gender-matched cohort with younger age patients and longer follow-up. The low prevalence of hepatitis B infection in the era of hepatitis B vaccine would make such studies difficult, and the prevalence of metabolic syndrome in younger patients would be low.Further studies should also investigate the effect of adipokines on viral clearance and validate the study findings in other populations. 3, 4ACKNOWLEDGEMENT The authors' declarations of personal and financial interests are unchanged from those in the original article.

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Opposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle-aged and elderly

et al. 2014

Self Cite

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Limited data exist regarding metabolic risk factors for deaths from hepatocellular carcinoma (HCC) in aging individuals. We investigated the association between diabetes, dyslipidemia, and HCC mortality in those aged 40 years or more (middle-aged and elderly). In this prospective cohort study based on nationwide health screening units, we consecutively followed middle-aged and elderly participants who had no chronic hepatitis B or C virus infection and received health screening from January 1 1998 to December 31 2008. There were 235 deaths from HCC among 50,080 individuals, ascertained by validated death certificates and the national death registry. Diabetes (adjusted hazard ratio [HR], 3.38; 95% confidence interval [CI], 2.35 to 4.86) was positively associated with deaths from HCC. However, hypertriglyceridemia (HR, 0.38; 95% CI, 0.26 to 0.55) and hypercholesterolemia (HR, 0.50; 95% CI, 0.37 to 0.67) were inversely associated with HCC mortality. The above significant associations remained in the lag time analyses, applied to check for reverse causation. Metabolic syndrome, as defined by the American Heart Association / National Heart Lung Blood Institute criteria (HR, 0.63; 95% CI, 0.46 to 0.86) or by the International Diabetes Federation criteria (HR, 0.62; 95% CI, 0.43 to 0.89), was inversely associated with deaths from HCC, especially in men. Conclusion: Middle-aged and elderly individuals, once having diabetes, deserve HCC surveillance to reduce HCC mortality. More research is needed to elucidate why having baseline dyslipidemia relates to lower future HCC mortality. (HEPATOLOGY 2014;59:2207-2215

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Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers

Cited by 31 publications

References 30 publications

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis

Editorial: metabolic syndrome delays HBeAg seroclearance in Chinese patients with hepatitis B – authors' reply

Opposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle-aged and elderly

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