Serum Adiponectin Concentration Prior to Clinical Onset of Preeclampsia

Odden, Nancy; Henriksen, Tore; Holter, Ellen; Skar, Anne Grete; Tjade, Trygve; Mørkrid, Lars

doi:10.1080/10641950600745475

Cited by 13 publications

(11 citation statements)

References 37 publications

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“…In our study, although pre-eclamptic women showed a slightly lower adiponectin than the control group, we did not observe any statistically significant difference in serum adiponectin between cases and controls both in univariate analysis and after adjustment for possible confounders. This finding is in accordance with two previous smaller studies showing no change in adiponectin values [29–30]. But controversial data exist in the literature regarding adiponectin as predictive marker of PE.…”

Section: Discussionsupporting

confidence: 93%

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

et al. 2011

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OBJECTIVE Conditions resulting in insulin resistance, as well as metabolic, immune and angiogenic perturbations, have been associated with an increased risk of preeclampsia (PE). Our purpose was to assess whether the adipose tissue secreted hormones: adiponectin, which has immune modulating, metabolic and angiogenic properties, and leptin, which reflects overall fat mass, are associated with PE risk. METHODS We performed a case-control design study within a hospital-based cohort of 368 pregnant women (106 with PE and 262 controls; mean age: 26.6 ± 6.8 years; mean gestational age at admission: 38.2 ± 2.8 weeks) between March 2005 and August 2007 at the Hospital of Pennsylvania University. Serum adiponectin and leptin were measured by radioimmunoassay. Statistical analysis of data was performed using simple and multiple regression analyses. RESULTS No significant differences in adiponectin or leptin levels between pre-eclamptic and control pregnant women emerged in univariate analyses (p=0.57 and p=0.15 respectively). Among pre-eclamptic women, there were also no differences in adipokines between those with mild and severe disease. Serum adiponectin and leptin were not associated with higher risk of PE before and after adjustment for maternal age, race, primigravida, smoking status, body mass index at screening, gestational age at admission, history of preeclampsia, chronic hypertension and gestational diabetes (OR: 0.93, 95% C.I.: 0.83–1.04 and OR: 1, 95% C.I.0.97–1.03, respectively). CONCLUSION Maternal serum adiponectin and leptin levels, drawn at the time of PE diagnosis, were not associated with PE.

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Section: Discussionsupporting

confidence: 93%

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

et al. 2011

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“…However, only one of such previous studies distinguished between early and late PE and reported that the levels of adiponectin were increased only in late PE [25] . Three previous studies examined firsttrimester maternal levels in women who subsequently developed PE and 1 reported no significant differences in adiponectin levels between cases and controls [10] , whereas 2 studies demonstrated that in the PE group the levels were decreased [9,26] . One of the studies examined differences between early and late PE and reported that significant reduction in plasma adiponectin was observed only in the cases that developed late PE [9] .…”

Section: Discussionmentioning

confidence: 99%

“…Maternal factorderived a priori risks for PE were determined as previously described and were then logarithmically transformed [17] . Logistic regression analysis was used to determine if the log-transformed maternal factor-derived a priori risks, sqrt adiponectin MoM, log 10 The statistical software package SPSS 16.0 (SPSS Inc., Chicago, Ill., USA) was used for data analyses.…”

Section: Discussionmentioning

confidence: 99%

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Maternal Serum Adiponectin at 11–13 Weeks of Gestation in Preeclampsia

Nanda

Giurcaneanu

et al. 2011

Fetal Diagn Ther

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Objective: To determine whether the maternal serum levels of adiponectin in the first trimester of pregnancy are altered in cases that develop preeclampsia (PE) and whether the levels are related to pregnancy-associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI). Methods: Serum adiponectin, PAPP-A and uterine artery PI were measured at 11–13 weeks in 90 cases that developed PE, including 30 that required delivery before 34 weeks (early PE) and 300 unaffected controls. The median adiponectin, PAPP-A and uterine artery PI multiple of the unaffected median (MoM) in the outcome groups were compared. Results: In both early PE and late PE, compared to controls, uterine artery PI MoM was increased (1.32 and 1.05 vs. 1.02) and PAPP-A MoM was decreased (0.61 and 0.84 vs. 1.00), whereas adiponectin MoM was increased in early PE but not in late PE (1.32 and 1.05 vs. 1.02). In the PE group, there was no significant association between adiponectin and PAPP-A or uterine artery PI. Serum adiponectin did not improve the performance of screening for PE provided by a combination of the maternal factors, uterine artery PI and serum PAPP-A. Conclusion: Serum adiponectin levels at 11–13 weeks are increased in women that develop early PE by a mechanism unrelated to impaired placentation.

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“…The evidence concerning maternal adiponectin concentrations in the presence of preeclampsia is inconsistent: higher [41, 58, 59, 70, 92, 112, 113, 116, 130, 159], lower [31, 33, 34, 63, 125], and similar adiponectin concentrations [119, 120, 145, 160] have been reported in patients with preeclampsia compared to normal pregnant women. This alleged inconsistency may be due to differences in the study population characteristics, definitions of preeclampsia (mild vs. severe, early vs. late onset), sample size or methods by which adiponectin concentrations were determined.…”

Section: Discussionmentioning

confidence: 99%

Maternal serum adiponectin multimers in preeclampsia

Mazaki‐Tovi¹,

Romero²,

Vaisbuch³

et al. 2009

Jpme

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Objective Obesity, insulin resistance, and dyslipidemia are associated with preeclampsia. Recently, “adipose tissue failure”, characterized by dysregulation of adipokine production, has been implicated in the pathophysiology of these metabolic complications. Adiponectin, an insulin-sensitizing, anti-atherogenic, anti-inflammatory and angiogenic adipokine, circulates in oligomeric complexes including: low-molecular-weight (LMW) trimers, medium-molecular-weight (MMW) hexamers and high-molecular-weight (HMW) isoforms. These multimers exert differential biological effects, and HMW to total adiponectin ratio (SA) has been reported to be a specific marker of adiponectin activity. The aim of this study was to determine whether preeclampsia is associated with changes in circulating adiponectin multimers. Study design This cross-sectional study included women with: 1) normal pregnancy (n=225); and 2) patients with mild preeclampsia (n=111). The study population was further stratified by first trimester BMI (normal weight <25 kg/m2 vs. overweight/obese ≥25 kg/m2). Serum adiponectin multimers (total, HMW, MMW and LMW) concentrations were determined by ELISA. Non-parametric statistics were used for analysis. Results 1) The median maternal HMW and LMW adiponectin concentrations were lower in patients with preeclampsia than in those with normal pregnancies (p<0.001 and p=0.01, respectively); 2) patients with preeclampsia had a lower HMW/Total adiponectin ratio (p<0.001) and higher MMW/Total adiponectin and LMW/Total adiponectin ratios than those with a normal pregnancy (p<0.001 and p=0.009, respectively); 3) the presence of preeclampsia was independently associated with lower maternal serum HMW adiponectin concentrations (p=0.001) and with a low HMW/Total adiponectin ratio (p<0.001) after correction for maternal age, maternal BMI, the difference in BMI between the third and the first trimester, and gestational age at sampling; and 4) overweight/obese pregnant women had a lower median total and HMW adiponectin concentration than normal weight pregnant women among women with normal pregnancies, but not among those with preeclampsia. Conclusion 1) Preeclampsia is associated with a lower median concentration of the HMW adiponectin isoform, the most active form of this adipokine, and a low HMW/Total adiponectin ratio, a specific marker of adiponectin biologic activity; 2) in contrast to normal pregnancy, preeclampsia is not associated with decreased circulating adiponectin multimers in overweight/obese individuals suggesting altered regulation of this adipokine in preeclampsia; 3) collectively, these findings suggest that preeclampsia is characterized by alterations in adiponectin multimers and their relative distribution implying a role for adiponectin multimers in the mechanism of disease in preeclampsia.

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Serum Adiponectin Concentration Prior to Clinical Onset of Preeclampsia

Abstract: Using this design, total adiponectin appeared not be a useful pre-clinical marker of PE.

Cited by 13 publications

References 37 publications

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

Maternal Serum Adiponectin at 11–13 Weeks of Gestation in Preeclampsia

Maternal serum adiponectin multimers in preeclampsia

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