Sertoli cell secretory function after hypophysectomy

Weddington, S. C.; Hansson, V.; Ritzén, E. M.; Hagenäs, Lars; French, Frank S.; Nayfeh, Shihadeh N.

doi:10.1038/254145a0

Cited by 49 publications

(11 citation statements)

References 10 publications

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“…6, only a few spermatocytes were observed close to atrophied Sertoli cells. Recently, it was demonstrated that FSH selectively stimulated Sertoli cells (de Kretser and Burger, 1972;Steinberger et al, 1975;Weddington et al, 1975;Ishii and Furuya, 1975;Dorrington et al, 1976;Hansson et al, 1976;Steinberger and Steinberger, 1976). The present results substantiate those reports.…”

Section: Resultssupporting

confidence: 95%

Histological Changes in the Testis of the Domestic Fowl After Partial Adenohypophysectomy

Tanaka

Fujioka

1981

Poultry Science

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The effects of partial adenohypophysectomy on comb size, testicular weight, and histology 20 or 30 days after the operation are described and discussed in relating these observed changes with the volume of remaining adenohypophyseal tissue. From the present observation, it is concluded that 1) the response of the domestic fowl to partial deficiency of adenohypophyseal tissue may be more sensitive than that of some mammals, 2) the decrease in testicular weight and tubular diameter precedes the histological change in testis and comb regression, and 3) to maintain fully active testicular function, more than 75% of the adenohypophysis is needed. About 40% of the adenohypophyseal tissue including a remnant of cephalic lobe can stimulate spermatogenesis, but the spermatozoa produced were partially abnormal. The critical amount of adenohypophyseal tissue for normal spermiogenesis may exist between 55 and 75%. All histological change is initially observed in the center of testis and then extended toward the periphery. It is suggested that the cephalic lobe contains at least a trace of ICSH in addition to FSH.

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Section: Resultssupporting

confidence: 95%

Histological Changes in the Testis of the Domestic Fowl After Partial Adenohypophysectomy

Tanaka

Fujioka

1981

Poultry Science

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“…Testosterone action on the Sertoli cell has also been shown (Means et al,1976 ;Hansson et al, 1978). Research on hypophysectomized animals (Weddington et al, 1975 ;Elkington et al, 1975Elkington et al, , 1977 suggests that FSH and testosterone effects are correlated in the production of androgen binding protein (ABP) (Means, 1977 ;Hansson et al, 1978). The culture of samples of testicular seminiferous tubules or of isolated Sertoli cells has confirmed all the results obtained so far (Hansson et al, 1978).…”

Section: Introductionsupporting

confidence: 65%

Development of Sertoli cell populations in organ culture of immature pig testis

Chevalier¹,

Dufaure²

1980

Reprod. Nutr. Dévelop.

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“…Androgen-binding protein (ABP) [4][5][6][7], plasminogen activator [8,9], transferrin [10], an oestrogen-like compound [11,12] and lactate [13,14] are all produced by Sertoli cells under the regulation of follicle-stimulating hormone (FSH). The secretion of ABP, which has become a standard index of Sertoli cell function, is also regulated by insulin [15], retinol [15], and possibly testosterone [16][17][18]. Lactate secretion is potentially of great importance to the function of the seminiferous tubule since it has been shown that germ cells prefer lactate to glucose as an energy substrate [19].…”

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confidence: 99%

Altered biochemical responses by rat Sertoli cells and peritubular cells cultured under simulated diabetic conditions

Hutson

1984

Diabetologia

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Summary.The purpose of the present study was to determine whether the secretion of androgen-binding protein and lactate by 16-day-old rat Sertoli cells is altered when these cells are cultured in simulated diabetic conditions. Incorporation of 3H-uridine into RNA by peritubular cells cultured in simulated diabetic conditions was also studied. The cells were exposed to various concentrations of glucose, r ate, sodium bicarbonate (to alter the pH of the medium), mannitol (to influence the osmolarity of the medium), or a combination of these compounds. All of the metabolic parameters when tested alone or in combination were capable of increasing lactate secretion by Sertoli cells above control values. Basal secretion of androgen-binding protein, however, was not influenced by any individual component or when all components were tested together. FSH-stimulated levels of androgen-binding protein secretion was depressed only when the Sertoli ceils were exposed to all the components simultaneously. Incorporation of uridine by peritubular cells was decreased by exposing the cells to butyrate or mannitol, while no effect was observed with glucose treatment. These results indicate that Sertoli cell and peritubular cell function can be directly altered by several specific metabolic parameters associated with diabetes.Key words: Sertoli cells, diabetes, androgen-binding protein.Reproductive dysfunction is commonly observed in long-term diabetic patients [1,2] as well as in experimentally-induced diabetic animals [3]. Since the Sertoli cells are thought to be involved in regulating spermatogenesis, it may be hypothesized that these cells are involved in this pathogenic process. Androgen-binding protein (ABP) [4][5][6][7], plasminogen activator [8,9], transferrin [10], an oestrogen-like compound [11,12] and lactate [13,14] are all produced by Sertoli cells under the regulation of follicle-stimulating hormone (FSH). The secretion of ABP, which has become a standard index of Sertoli cell function, is also regulated by insulin [15], retinol [15], and possibly testosterone [16][17][18]. Lactate secretion is potentially of great importance to the function of the seminiferous tubule since it has been shown that germ cells prefer lactate to glucose as an energy substrate [19]. However it is not known if the secretion of lactate is altered in diabetic animals.In a previous study, it was demonstrated that levels of ABP in the epididymides of streptozotocin-induced diabetic animals were significantly higher 4 weeks after treatment than in control animals [20]. Murray et al. [21] reported that the level of ABP in the epididymides of streptozotocin-induced diabetic rats was only elevated 3weeks after streptozotocin treatment; at 1, 2 and 4 weeks after treatment, the levels of ABP were normal. However it is not known whether the increased levels of ABP in the epididymides of diabetic animals are a result of increased secretion of ABP by Sertoli cells, or of decreased transport or decreased turnover of ABP in the epididymis. In addition, i...

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Sertoli cell secretory function after hypophysectomy

Cited by 49 publications

References 10 publications

Histological Changes in the Testis of the Domestic Fowl After Partial Adenohypophysectomy

Histological Changes in the Testis of the Domestic Fowl After Partial Adenohypophysectomy

Development of Sertoli cell populations in organ culture of immature pig testis

Altered biochemical responses by rat Sertoli cells and peritubular cells cultured under simulated diabetic conditions

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