Serous Retinal Detachments in Thrombotic Thrombocytopenic Purpura

Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?

“…There are few reports on ocular involvements in adult patients with TTP [8,11]. These patients have not been investigated for complement system abnormalities or ADAMTS13 deficiency.…”

“…Other organs may Ocular involvement has never been reported in patients with factor H abnormalities. However, in the literature on adults, retinal detachment [8], choroidal hemorrhage [9], vitreous hemorrhage [10] and thrombosis of the retinal artery [11] have been reported in patients with thrombotic thrombocytopenic purpura (TTP).…”

Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?

“…There are few reports on ocular involvements in adult patients with TTP [8,11]. These patients have not been investigated for complement system abnormalities or ADAMTS13 deficiency.…”

“…Other organs may Ocular involvement has never been reported in patients with factor H abnormalities. However, in the literature on adults, retinal detachment [8], choroidal hemorrhage [9], vitreous hemorrhage [10] and thrombosis of the retinal artery [11] have been reported in patients with thrombotic thrombocytopenic purpura (TTP).…”

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship

“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”

Ocular manifestations of primary thrombotic microangiopathies : a descriptive systematic review

“…We found that retinal hemorrhages, PLR, retinal detachments, optic disc changes, isolated cotton-wool spots, and capillary non-perfusion on FFA are common ocular findings in PTMAs. While ocular manifestations in PTMAs are rarely reported, they are still important as they can also be the presenting feature of the disease, as was discussed by Ong et al [ 40 ] or they can be late manifestations, as was discussed by Lambert et al [ 42 ]. Several other rare ocular manifestations were also identified and still pose important clinical significance.…”

Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?

“…There are few reports on ocular involvements in adult patients with TTP [8,11]. These patients have not been investigated for complement system abnormalities or ADAMTS13 deficiency.…”

“…Other organs may Ocular involvement has never been reported in patients with factor H abnormalities. However, in the literature on adults, retinal detachment [8], choroidal hemorrhage [9], vitreous hemorrhage [10] and thrombosis of the retinal artery [11] have been reported in patients with thrombotic thrombocytopenic purpura (TTP).…”

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship

“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”

Ocular manifestations of primary thrombotic microangiopathies : a descriptive systematic review

“…We found that retinal hemorrhages, PLR, retinal detachments, optic disc changes, isolated cotton-wool spots, and capillary non-perfusion on FFA are common ocular findings in PTMAs. While ocular manifestations in PTMAs are rarely reported, they are still important as they can also be the presenting feature of the disease, as was discussed by Ong et al [ 40 ] or they can be late manifestations, as was discussed by Lambert et al [ 42 ]. Several other rare ocular manifestations were also identified and still pose important clinical significance.…”

Ocular involvement in hemolytic uremic syndrome due to factor H deficiency—are there therapeutic consequences?

“…There are few reports on ocular involvements in adult patients with TTP [8,11]. These patients have not been investigated for complement system abnormalities or ADAMTS13 deficiency.…”

“…Other organs may Ocular involvement has never been reported in patients with factor H abnormalities. However, in the literature on adults, retinal detachment [8], choroidal hemorrhage [9], vitreous hemorrhage [10] and thrombosis of the retinal artery [11] have been reported in patients with thrombotic thrombocytopenic purpura (TTP).…”

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship

“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”

Ocular manifestations of primary thrombotic microangiopathies : a descriptive systematic review

“…We found that retinal hemorrhages, PLR, retinal detachments, optic disc changes, isolated cotton-wool spots, and capillary non-perfusion on FFA are common ocular findings in PTMAs. While ocular manifestations in PTMAs are rarely reported, they are still important as they can also be the presenting feature of the disease, as was discussed by Ong et al [ 40 ] or they can be late manifestations, as was discussed by Lambert et al [ 42 ]. Several other rare ocular manifestations were also identified and still pose important clinical significance.…”