2016
DOI: 10.1186/s12879-016-1668-y
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Abstract: BackgroundDengue is caused by a RNA virus of the family Flaviviridae, which presents four serotypes (DENV-1 to DENV-4) capable of inducing hemorrhage. The purpose of this study was to evaluate the influence of serotype on the outcome of dengue.MethodsThis cross-sectional study included data from dengue cases with serotyping results that occurred between 2009 and 2013 in Vitória, Espírito Santo, Brazil. Data were accessed through the Information System for Notifiable Diseases. Chi-square test, Fisher exact test… Show more

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Cited by 88 publications
(66 citation statements)
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“…Among the patients, 30.7% showed improved management of DF diagnosis and treatment. The indings of the present study are also lower than those derived in research in Brazil (i.e., 6.5%) (Vicente et al, 2016).…”
Section: The Relationship Between Subclinical Characteristics and Dencontrasting
confidence: 83%
“…Among the patients, 30.7% showed improved management of DF diagnosis and treatment. The indings of the present study are also lower than those derived in research in Brazil (i.e., 6.5%) (Vicente et al, 2016).…”
Section: The Relationship Between Subclinical Characteristics and Dencontrasting
confidence: 83%
“…methods such as detecting SNVs in RNA or compatibility with isothermal amplification of substrate 29 . At the level of RNA, by appending a Reverse Transcription (RT) step prior to amplification, we could successfully distinguish two Dengue virus serotypes (West Pac/74 and P23085, designated 1 and 2) that lead to variable mortality rates in patients (Supplementary Figure 6) 30,31 . To circumvent the need of complex instrumentation for preamplification, we optimized Recombinase Polymerase Amplification (RPA) for generating amplicons that can contribute to a field deployable assay prototype (Supplementary Figure 7A-B) 32 .…”
Section: Feluda Detection Can Be Customized With Other Features Of Cumentioning
confidence: 99%
“…Once the biological prognostic markers for severe dengue fever are identified, their validation will require large and independent cohorts of dengue patients who differ in ages and immune status. Regarding the pathogenic properties of DENV, it has been widely reported that DENV-2 infection causes a greater number of severe cases than other serotypes [22].…”
Section: Asymptomatic and Symptomatic Cases Of Denguementioning
confidence: 99%