Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates collected at a Chinese hospital from 2011 to 2013

Abstract

BackgroundStreptococcus pneumoniae infections are a major cause of global morbidity and mortality, and the emergence of antibiotic-resistant Streptococcus pneumoniae strains has been increasingly reported. This study provides up-to-date information on bacterial serotype distribution and drug resistance from S. pneumoniae clinical isolates that could guide prevention and treatment strategies for pneumococcal disease in China.MethodsA total of 94 S. pneumoniae isolates were collected from outpatients and inpatients at one Chinese hospital from 2011–2013. Drug susceptibility and resistance was determined by minimum inhibitory concentrations (MICs). Capsular serotypes were identified by the quellung reaction test and multiplex polymerase chain reaction.ResultsFifteen serotypes were identified among the 94 S. pneumoniae clinical isolates that were collected. Prevalent serotypes were 19F (42.6 %), 19A (8.5 %), 3 (8.5 %), and 6B (7.4 %). Potential immunization coverage rates for the 7-, 10- and 13-valent pneumococcal polysaccharide conjugate vaccines were 59.6, 62.6, and 79.6 %, respectively. Resistance rates to tetracycline, erythromycin, and trimethoprim/sulfamethoxazole were 91.2, 80.2 and 63.8 %, respectively. Resistance rates to penicillin, amoxicillin, ceftriaxone, and cefotaxime were 47.3, 34.1, 19.8, and 18.7 %, respectively. In almost all cases, antimicrobial resistance of the S. pneumoniae isolates in patients five years or younger was higher than isolates collected from patients aged 51 years or older.ConclusionPrevalent serotypes among the 94 S. pneumoniae clinical isolates were 19F, 19A, 3, and 6B. The 13-valent pneumococcal polysaccharide conjugate vaccine covered the majority of the serotypes identified in this sample. Drug resistance varied among different serotypes and age groups. Clinical precautions should be taken to avoid the development of multidrug resistance in this potential human pathogen.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-015-1042-5) contains supplementary material, which is available to authorized users.

Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae strains in the south of Tunisia: A five-year study (2012–2016) of pediatric and adult populations

“…Concerning the macrolides, the overall erythromycin resistance rate was 71.4%. This rate is similar to that reported in a previous Tunisian study on pneumococcal infections (64.7%), but lower than the rate reported in Chinese studies (Charfi et al, 2012;Huang et al, 2015;Pan et al, 2015). Europe and the USA have reported prevalence rates of approximately 30% .…”

Serotypes and antibiotic susceptibility profile of encapsulated <i>Streptococcus pneumoniae</i> strains isolated from under five years old children

“…It has been reported that patterns of change in serotype distribution varies among countries and regions (Hecini-Hannachi et al, 2014;Huang et al, 2015). Serotype 14 has been described as one of the most common serotype causing invasive pneumococcal disease in children less than five years old children (Imöhl et al, 2010, Hecini-Hannachi et al, 2014.…”

Prevalence and Antibiotic Resistance Pattern of Streptococcus Pneumoniae, Isolated From Invasive and Non-Invasive Infections in a Tertiary Care Hospital of Karachi.

“…Current study exhibited high resistance of Ofloxacin in adults but only 1.1 % of Ofloxacin-non-susceptible isolates are reported, although the rate of Fluoroquinolone resistance is low in this region [28]. Development of resistance to Fluoroquinolones is due to the mutations of gyrA and parC genes that further encode type II topoisomerase subunits also called quinolone-resistance determining regions [29]. Clindamycin resistance plus macrolide resistance is a suitable indicator for detection of the erm (B) resistance marker [24].…”