Serotonin receptors of lymphocytes: A radioreceptor study

Vetoshkin, A. V.; Fomenko, Andrey M.; Zozulya, A. A.

doi:10.1007/bf00830956

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Binding and pharmacological studies have shown that both human and mouse T and B possess 5-HT receptors [39][40][41][42]. Bonnet et al [40] did not detect any 5-HT receptors in mouse peritoneal macrophages by binding experiments.…”

Section: -Ht Receptorsmentioning

confidence: 98%

Serotonin as a Modulator of Immune Function: An Overview

Cloëz‐Tayarani

2006

CIR

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The CNS and immune system interact in a reciprocal manner through a wide variety of common mediators including neurotransmitters and cytokines. Among the former, serotonin (5-Hydroxytryptamine = 5-HT) plays a major role in the control of neuronal activity. It may also control the level of cytokines and lymphocyte proliferation. 5-HT is synthesized and released in the circulation by enterochromaffin cells from gastric and intestinal mucosa. Under inflammatory conditions such as thrombosis and ischemia, the activated platelets release 5-HT at the site of inflammation and lead to an increase in its local concentration. In addition to its possible interaction with blood cells, 5-HT may also interact with the inflamed tissue macrophages through its various receptors. Accordingly, 5-HT transporters and 5-HT receptor subtypes have been characterized in different blood cells. This review provides an overview of reported data on the regulatory role of 5-HT on the activity of peripheral blood cells. Such role includes both immunostimulatory and immunoinhibitory effects based on 5-HT concentration and its cellular target. In the light of recent data, this review also speculates on the intracellular processes (i.e. MAP kinases), which are activated by 5-HT suggesting neuromodulatory function.

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Section: -Ht Receptorsmentioning

confidence: 98%

Serotonin as a Modulator of Immune Function: An Overview

Cloëz‐Tayarani

2006

CIR

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“…In the blood stream, they must interact with circulating peripheral blood mononuclear cells (PBMCs), which express a wide array of nonsynaptic membrane receptors. These nonsynaptic receptors include those that have demonstrable chromatin-modifying effects, such as the dopamine D2–D5 receptors [21,22], serotonin receptors [23], adrenergic receptors [24], dopamine and serotonin transporters [25], nicotine [26] and opioid receptors [27]. It is almost certain that cellular signaling cascades triggered by these membrane receptors will contribute to the totality of changes in PBMC chromatin [28].…”

Section: Epigenetic Modifiers Are Ambient In Both Peripheral and Centramentioning

confidence: 99%

Blood Chromatin as a Biosensor of the Epigenetic Milieu: A Tool for Studies in Living Psychiatric Patients

Sharma

2012

Epigenomics

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This article constructs an argument for using blood chromatin (contained in nucleated blood cells) as a protein biosensor to integrate the ambient epigenetic influences in the internal milieu. An analogy is made to blood glycated hemoglobin (HbA1c) in diabetes as an integrated proxy for glucose levels and body-wide protein glycation. Genome-wide chromatin can serve as an organizing principle that bridges the central and peripheral compartments by entraining commensurable gene networks. Chromatin deposition along these networks will be imposed by the totality of epigenetic influences, which incorporates significant contributions from biochemicals that readily traverse the blood–brain barrier. In a clinical trial, these influences would be dominated by pharmaceuticals designed to override pathophysiological signals. In practice, mRNA readouts would be limited to nonsynaptic gene networks whose critical nodes are occupied by a site-specific chromatin modification. Finally, chromatin measurements in peripheral tissue will retain the influences of a patient’s lifestyle and unique genomic background.

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