Serotonergic function in panic disorder: Endocrine responses to d-Fenfluramine

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

“…The conclusion was drawn that these challenges stimulate different neurobiological mechanisms and that the fenfluramine-precipitated anxiety is more akin to anticipatory or generalized anxiety than to the true panic attack. Nevertheless, the results of a similar study by Judd et al (1994) have shown no significant difference between PD patients and controls in both the cortisol and prolactin responses to fenfluramine.…”

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

“…The conclusion was drawn that these challenges stimulate different neurobiological mechanisms and that the fenfluramine-precipitated anxiety is more akin to anticipatory or generalized anxiety than to the true panic attack. Nevertheless, the results of a similar study by Judd et al (1994) have shown no significant difference between PD patients and controls in both the cortisol and prolactin responses to fenfluramine.…”

L -5-Hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

“…d-Fenfluramine on the other hand, is specific for 5-HT neurons (Garattini et al 1987). Accordingly, a study using d-fenfluramine found no differences in cortisol response between PD patients and controls (Judd et al 1994). …”

In vivo Serotonin-Sensitive Binding of [ 11 C]CUMI-101: A Serotonin 1A Receptor Agonist Positron Emission Tomography Radiotracer

“…Serotonin 1A (5-hydroxytryptamine, 5-HT 1A ) receptor binding measured with in vivo imaging has been found to be altered in mood disorders (Parsey et al, 2006), anxiety disorders (Judd et al, 1994), and some (Abi-Dargham et al, 1997), but not all (Frankle et al, 2006), schizophrenia studies. All published human imaging studies to date have used an antagonist as the imaging ligand, most commonly [ 11 C]WAY100635.…”

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

“…The conclusion was drawn that these challenges stimulate different neurobiological mechanisms and that the fenfluramine-precipitated anxiety is more akin to anticipatory or generalized anxiety than to the true panic attack. Nevertheless, the results of a similar study by Judd et al (1994) have shown no significant difference between PD patients and controls in both the cortisol and prolactin responses to fenfluramine.…”

L -5-Hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

“…d-Fenfluramine on the other hand, is specific for 5-HT neurons (Garattini et al 1987). Accordingly, a study using d-fenfluramine found no differences in cortisol response between PD patients and controls (Judd et al 1994). …”

In vivo Serotonin-Sensitive Binding of [ 11 C]CUMI-101: A Serotonin 1A Receptor Agonist Positron Emission Tomography Radiotracer

“…Serotonin 1A (5-hydroxytryptamine, 5-HT 1A ) receptor binding measured with in vivo imaging has been found to be altered in mood disorders (Parsey et al, 2006), anxiety disorders (Judd et al, 1994), and some (Abi-Dargham et al, 1997), but not all (Frankle et al, 2006), schizophrenia studies. All published human imaging studies to date have used an antagonist as the imaging ligand, most commonly [ 11 C]WAY100635.…”

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

“…The conclusion was drawn that these challenges stimulate different neurobiological mechanisms and that the fenfluramine-precipitated anxiety is more akin to anticipatory or generalized anxiety than to the true panic attack. Nevertheless, the results of a similar study by Judd et al (1994) have shown no significant difference between PD patients and controls in both the cortisol and prolactin responses to fenfluramine.…”

L -5-Hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

“…d-Fenfluramine on the other hand, is specific for 5-HT neurons (Garattini et al 1987). Accordingly, a study using d-fenfluramine found no differences in cortisol response between PD patients and controls (Judd et al 1994). …”

In vivo Serotonin-Sensitive Binding of [ 11 C]CUMI-101: A Serotonin 1A Receptor Agonist Positron Emission Tomography Radiotracer

“…Serotonin 1A (5-hydroxytryptamine, 5-HT 1A ) receptor binding measured with in vivo imaging has been found to be altered in mood disorders (Parsey et al, 2006), anxiety disorders (Judd et al, 1994), and some (Abi-Dargham et al, 1997), but not all (Frankle et al, 2006), schizophrenia studies. All published human imaging studies to date have used an antagonist as the imaging ligand, most commonly [ 11 C]WAY100635.…”