Seroprevalence of Toxoplasma gondii infection among Iranian pregnant women: a systematic review and meta-analysis

Malary, Mina; Hamzehgardeshi, Zeinab; Moosazadeh, Mahmood; Afshari, Mahdi; Ahmadi, Imaneh; Moghaddasifar, Iman; Kheradmand, Motahareh

doi:10.26719/2018.24.5.488

Cited by 14 publications

(14 citation statements)

References 16 publications

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“…The results of UCB serologic testing showed a prevalence of 6% and 36% for anti‐ Toxoplasma IgM and IgG antibodies, respectively. These results are in accordance is with other reported prevalence among pregnant women from Egypt; 30.16% and 33.79% and also from other countries as 40.15% for IgG and 9% for IgM in Northern Tanzania, 41.3% for IgG in Iran, 32.5% for IgG and 6.4% for IgM in Saudi Arabia and 51% for IgG and 0% for IgM in Brazil . Results of PCR was 11% indicating active infection.…”

Section: Discussionsupporting

confidence: 92%

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

Botein

Darwish

El-Tantawy

et al. 2019

Transplant Infectious Dis

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Background: Human umbilical cord blood has proven to be a successful alternate source of hematopoietic stem cells for pediatric patients with major hematologic disorders. Toxoplasma gondii is a global opportunistic protozoan which cause fatal complications in immunocompromised individuals. Aim:Our goal is to study the prevalence of toxoplasmosis in umbilical cord blood (UCB) and to assess the sensitivity of ELISA and PCR for Toxoplasma infection screening. Material and Methods:One hundred cord blood samples were collected immediately after delivery. Anti-Toxoplasma IgG and IgM antibodies were determined using ELISA method; Toxoplasma DNA was detected using nested PCR technique. Total nucleated cells (TNC) and HB were also determined. Demographic data and risk factors data related to the transmission of toxoplasmosis, were collected from mothers. Results:Among 100 cord blood samples, 36 (36%) were positive for anti-Toxoplasma IgG antibodies and 6 (6%) were positive for anti-Toxoplasma IgM antibodies. The nested PCR showed 11 (11%) samples containing Toxoplasma DNA from which, 6 (55%) samples were IgM positive. There was no significant association between the risk of Toxoplasma transmission and cord blood positivity for toxoplasmosis. Conclusion:Owing to the prevalence of toxoplasmosis, its rapid progression and its fatal outcome in immunocompromised patients, cord blood screening for toxoplasmosis with nested PCR should be incorporated into cord blood bank screening protocols. K E Y W O R D Sbank, cord blood, diagnosis, screening, Toxoplasma

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Section: Discussionsupporting

confidence: 92%

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

Botein

Darwish

El-Tantawy

et al. 2019

Transplant Infectious Dis

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“…This is higher than the study conducted in China and Iran which showed a seroprevalence of 5.0% [54] and 38% [55] respectively among pregnant women. However, relatively similar seroprevalence (41.3%) has been reported in Iranian pregnant women [56]. The high seroprevalence of T. gondii among pregnant women could be due to decreased immunity and physiological changes during pregnancy, decreased awareness, as well as increased risk of exposure.…”

Section: Pooled Prevalencementioning

confidence: 61%

WITHDRAWN: Sero-epidemiology of Toxoplasma gondii and risk factors among pregnant women in Africa

Kajeguka

Anderson

Mawazo

et al. 2019

Preprint

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Introduction Infections caused by Toxoplasma gondii is a great public health concern worldwide. Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the fetus. Serologic studies have reported various estimates for seroprevalence of toxoplasmosis among African pregnant women. Estimation of the pooled seroprevalence of this infection is necessary for policy-making and target intervention.Methods We conducted this systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A rigorous literature selection was performed by using the databases of PubMed, Google Scholar, and ScienceDirect for the period Jan 1, 2001, to July 31, 2019. Sero-prevalence with 95% CI was presented for each study, and point estimates and their 95% CIs of pooled seroprevalence was then calculated.Findings The search process resulted in the inclusion of a total of 36 studies in the systematic review and meta-analysis. The pooled seroprevalence of Toxoplasma gondii Immunoglobulin G (IgG) in Africa was found to be 46.7% (95%CI: 37.0, 56.4). Geographical-based subgroup analysis showed that the seroprevalence of T. gondii among pregnant women was found to be 65.1% (95% CI: 44.7, 85.5), 50.2% (95% CI: 32.0, 68.3), 47.8% (95% CI: 31.7, 63.8), 38.3% (95% CI: 25.2, 51.4) and 5.8% (95% CI: 3.6, 8.1) in Central, Eastern, Northern, Western and Southern Africa respectively. The most common risk factors for T. gondii were living or contact with cat and consumption of raw vegetables or fruits.Conclusion The current systematic review and meta-analysis revealed a high seroprevalence of Toxoplasma gondii infection among pregnant women. There is a need to establish prevention and control measures that should be directed to educational programs. We recommend that periodic screenings for Toxoplasma gondii infection among pregnant women should be incorporated into routine clinical care in order to avoid serious clinical complications of mother and fetus.

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“…[ 1 ] and Malary et al . [ 39 ] reported in a systematic review and meta-analysis of pregnant women that 4.37% and 39.2% seroprevalence of IgG anti-Toxoplasma gondii antibodies in china and Iran, respectively.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses

Rahmanian

Jahromi

et al. 2020

J Family Med Prim Care

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Objectives: Toxoplasmosis is one of the neglected parasitic disease in humans and animals that produced via toxoplasma gondii. This study we implemented an umbrella review of all existing systematic reviews, meta-analyzing studies to apprise, and summarize seroprevalence of human toxoplasmosis in worldwide. Methods: The search was carried out in databases including: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Cochrane, and global health from their start dates until December 2018 in Persian and English language. A total of 21 systematics review and meta-analysis met the inclusion criteria of umbrella review. The Q test and the I 2 statistic were used to evaluate heterogeneities. Quality assessment were performed and made use of the AMSTAR tool. Results: The estimated pooled seroprevalence of T. gondii infection in blood donors, Immunocompromised patients, childbearing age women, general population, newborns and children, pregnant women and overall was 33% (95% CI, 29.0–38.0%), 42.0% (95 CI, 34.0–49.0%), 32.0% (CI, 26.0–38.0%), 42.0% (CI, 38.0–45.0%), 4.0% (CI, 2.0–5.0%), 40.0% (CI,37.0–44.0%), and 36% (CI, 24.0–48.0%), respectively. Conclusion: The results of our umbrella review show a higher seroprevalence of T. gondii infection in immunocompromised patients, general population, pregnant women, blood donors, childbearing age women, and newborn groups, respectively. Routine serologic screening test and health education by primary care physicians for Toxoplasmosis is recommended to be conducted in high-risk groups in the endemic region.

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Seroprevalence of Toxoplasma gondii infection among Iranian pregnant women: a systematic review and meta-analysis

Cited by 14 publications

References 16 publications

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

Serological and molecular screening of umbilical cord blood for Toxoplasma gondii infection

WITHDRAWN: Sero-epidemiology of Toxoplasma gondii and risk factors among pregnant women in Africa

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses

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