Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis

Anvari, Davood; Sharif, Mehdi; Sarvi, Shahabeddin; Aghayan, Sargis A.; Gholami, Shirzad; Pagheh, Abdol Sattar; Hosseini, Seyed Abdollah; Saberi, Reza; Nayeri, Tooran; Hosseininejad, Zahra; Daryani, Ahmad

doi:10.1016/j.micpath.2019.01.040

Cited by 36 publications

(35 citation statements)

References 65 publications

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“…Although some reports indicate a possible association between T . gondii infection and malignancies [ 9 , 15 , 16 ], the infection status of T . gondii in patients with CRC remains unclear in eastern China.…”

Section: Discussionmentioning

confidence: 99%

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Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

Guo

et al. 2020

BioMed Research International

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The aim of this study was to explore the epidemiology of Toxoplasma gondii infection in patients with colorectal cancer (CRC) in eastern China. Therefore, 287 primary CRC patients and 287 age-matched healthy control subjects were recruited to estimate the seroprevalence of T. gondii and identify the risk factors of infection. Enzyme-linked immunoassays were used to test for anti-T. gondii immunoglobulin G (IgG) and IgM antibodies. Forty-six (16%) samples were positive for anti-T. gondii IgG antibodies in patients with CRC, compared with 26 (9.1%) in the healthy controls, a significant difference ( P = 0.007 ). By contrast, eight (2.8%) patients tested positive for T. gondii IgM antibodies, compared with three (1.1%) in the controls, a difference that was not significant ( P = 0.13 ). Multivariable backward stepwise logistic regression analysis revealed that a rural residence (OR 2.83; 95% CI 1.15–7.01; P = 0.024 ) and treatment with chemotherapy (OR 2.16; 95% CI 1.02–4.57; P = 0.045 ) were risk factors for T. gondii infection in patients with CRC. Thus, T. gondii infection is serious in patients with CRC, and a rural residence and treatment with chemotherapy are independent risk factors for infection by this parasite. Therefore, medical professionals should be aware of this pathogen in patients with CRC, and the causes of T. gondii infection in these patients need to be explored further.

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Section: Discussionmentioning

confidence: 99%

“…The rate of T . gondii infection increases with age [ 24 , 25 ] and is affected by sex [ 16 ]. These associations can be explained because the possibility of infection increases with age and depends on type of occupation, often sex-related, with an opportunistic pathogen such as T .…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

Guo

et al. 2020

BioMed Research International

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“…We pooled each study estimate using a random-effects model to obtain an overall summary estimate of each Echinococcus isolate genotype (G1, G2, G3, and G6), as well as the accompanying 95% confidence intervals (CIs). Heterogeneity between the results was assessed based on the Q test and the I 2 indicator [37-39]. In addition, the Egger test was used to investigate the presence of publication bias.…”

Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

et al. 2019

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Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the World Health Organization. Due to the diversity of Echinococcus spp. hosts, as well as variation in geographical, climatic, and socio-ethnic conditions, the question of the strains or genotypes of Echinococcus spp. that are involved in human infections is important. The aim of this study was to provide a summary of the available data on genotypes of Echinococcus obtained from the Iranian population. Four international databases (PubMed, Scopus, Science Direct, and Web of Science) and 4 Persian databases (Magiran, Scientific Information Database, Iran Medex, and IranDoc) were searched for cross-sectional studies that reported the genotypes of Echinococcus spp. in human echinococcosis cases using molecular methods in Iran through July 2018. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. A total of 559 cases of human cystic echinococcosis were reported in the 21 included articles. The majority of cases belonged to genotype G1 (89.2%; 95% confidence interval [CI], 80.1 to 95.8), genotype G6 (8.2%; 95% CI, 2.8 to 15.9), and genotype G3 (2.3%; 95% CI, 1.1 to 3.9). Since genotype G1 of Echinococcus appears to be the most prevalent genotype affecting humans in Iran, disease control initiatives aimed at sheep intermediate hosts may be the most beneficial. In addition, educational programs and serological screening in individuals may help reduce the national impact of the disease.

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“…In the present review, an I 2 value of >75% was considered to be indicative of significant heterogeneity, warranting the implementation of an analysis with a random-effects model as opposed to the fixed-effects model to adjust for the observed variability. This heterogeneity was further explored through subgroup analyses (Rothstein et al, 2005;Hosseininejad et al, 2018;Saberi et al, 2018;Anvari et al, 2019Anvari et al, , 2020Chegeni et al, 2019). The subgroup analyses were performed based on the year, continent, country, gender, infected organ, fertility rate and applied diagnostic test.…”

Section: Meta-analysismentioning

confidence: 99%

The global status and genetic characterization of hydatidosis in camels (Camelus dromedarius): a systematic literature review with meta-analysis based on published papers

et al. 2020

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Hydatidosis is a potential zoonotic helminthic disease affecting a broad spectrum of mammals, including humans, worldwide. The current review was conducted to investigate the genotypic status and prevalence of hydatid disease in camels across the world. For the purpose of the study, the articles addressing the worldwide prevalence of hydatidosis in camels were searched in several English language databases. The search process resulted in the inclusion of 122 papers. Based on the data presented in the reviewed articles, the pooled prevalence of hydatid disease in camels across the world was measured at 23.75% (95% CI 20.15–27.55). Moreover, the subgroup analysis demonstrated significant differences in the overall prevalence of hydatidosis among camels based on year, geographic area, climate parameters, camel population, gender, infected organ, fertility rate of the cyst and laboratory diagnostic technique. Furthermore, the Echinococcus granulosus genotypes identified in camels with hydatidosis included G1, G2, G3, G1–G3, G5, G6, G7, G6–G7 and G6–G10, with G6 being the most common genotype throughout the world. The data obtained from the current study are central to the better conceptualization of the biological and epidemiological characteristics of E. granulosus s.l. genotypes around the world, which can be helpful in the planning and adoption of more comprehensive control strategies.

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Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis

Cited by 36 publications

References 65 publications

Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country

The global status and genetic characterization of hydatidosis in camels (Camelus dromedarius): a systematic literature review with meta-analysis based on published papers

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