Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics

Mathur, M; Wanjari, K; Turbadkar, Dilip

doi:10.4103/0255-0857.40552

Cited by 7 publications

(9 citation statements)

References 1 publication

(1 reference statement)

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“…However, a similar study conducted from the same state [6] showed extremely high prevalence of hepatitis C infection. This high prevalence of hepatitis C infection is in line with similar contemporary study [7].…”

Section: To the Editorsupporting

confidence: 91%

“…Studies conducted in and around 1988 showed extremely high prevalence of HIV infection in the range of 14-18 % among multitransfused thalassemic patients [2,3] while prevalence of hepatitis B and C virus infection remained at 14 and 25-38 %, respectively [4,5]. Post 2002 studies [1,6,7] including the present one show interesting data. In the present study (1), the TTI in multitransfused thalassemics have been reduced substantially almost to the level of their prevalence in normal population.…”

Section: To the Editormentioning

confidence: 55%

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Transfusion Transmitted Infections in Indian Thalassemics: A Perspective

Gorakshakar

Ghosh

2012

Indian J Hematol Blood Transfus

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Section: To the Editorsupporting

confidence: 91%

Section: To the Editormentioning

confidence: 55%

Transfusion Transmitted Infections in Indian Thalassemics: A Perspective

Gorakshakar

Ghosh

2012

Indian J Hematol Blood Transfus

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“…Blood transfusion, a lifesaving modality, can be made safer by the introduction of the NAT for screening of blood units for HIV, hepatitis B and hepatitis C viruses and it can be made cost-effective by Analysing multiple samples together. 26 Education regarding transfusion transmitted infections, including HCV, HBV and HIV infections, is of prime importance. Further, in all the centres taking care of thalassemia management, uniform strict criteria for donor selection should be adopted.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

2017

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Background: Patients of thalassemia who are conventionally treated by a regular transfusion regimen are at a risk of developing transfusion transmissible infections, including hepatitis. The present study was conducted to assess the prevalence of hepatitis B and hepatitis C virus infections among repeatedly transfused thalassemia patients.Methods: A total of 207 patients of beta-thalassemia, who had received at least 10 transfusions were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibody using enzyme linked immunosorbant assay (ELISA).Results: The overall number of anti-hepatitis C antibody seropositive was 51 (24.6%) and that for hepatitis B surface antigen positives was 7 (3.38%). The prevalence rate for hepatitis B surface antigen was in agreement with average national values, but in case of anti-HCV antibodies the prevalence rate values were comparatively much higher.Conclusions: Stringent measures need to be taken on urgent basis while screening blood for anti-hepatitis C antibody and hepatitis B surface antigen including inclusion of other sensitive assay like nucleic acid test (NAT) as well as better donor recruitment.

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“…Of the onetime studies: in reports from Northern India 21% HCV prevalence has been indicated (Jaiswal, et al , ). With 126 patients, age group 10 months to 22 years, Mathur et al () report an average of 43% prevalence of HCV. In a further breakdown based on the number of transfusions, >50 transfusions resulted in 57% HCV prevalence.…”

Section: Tti Prevalence Studies In Thalassaemics In Indiamentioning

confidence: 99%

Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India

Shyamala

2014

Transfusion Medicine

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The aim of the study was to assess the blood safety in India through prevalence in thalassaemic population. Safety of the blood supply is a subject of great concern for all recipients. This review attempts to assess the relevance and format of tests for viruses in the context of transfusion transmitted infection (TTI) prevalence in India. Serological marker testing for human immunodeficiency virus-1/2 (HIV-1/2), hepatitis C virus (HCV) and hepatitis B virus (HBV) is mandatory in India. Numerous TTI incidents in the repeat recipients supported by results from nucleic acid technology (NAT) testing indicate the deficiencies in blood safety. The β-thalassaemic population (3-17%) in India has been used to reflect on blood safety. The prevalence of HIV-1/2, HCV and HBV in the Indian donor population, the limitations in accessing safe donors, quality of serological tests and the impact on repeat recipients is evaluated. The reports point to prevalence of ˜2% of viral diseases in the blood donor population, and the insufficiency of serology testing resulting in up to 45% TTIs in thalassaemics. The revelation by individual donation (ID) NAT testing, of 1 per 310 units being serology negative-NAT reactive is alarming. Extrapolating the serology negative NAT reactive yields, for an annual blood supply of 7.9 million units, 23,700 units or nearly 100,000 blood components are likely to be infectious. Though the cost for ID-NAT testing is considered unaffordable for a medium development country such as India, the enormity of TTIs will place an unmanageable cost burden on the society.

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Seroprevalence of HIV, hepatitis C and hepatitis B in multitransfused thalassemics

Cited by 7 publications

References 1 publication

Transfusion Transmitted Infections in Indian Thalassemics: A Perspective

Transfusion Transmitted Infections in Indian Thalassemics: A Perspective

Prevalence of hepatitis B and hepatitis C virus infection in repeatedly transfused thalassemics in a tertiary care hospital in eastern India

Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India

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