Seroprevalence of Hepatitis B markers in pregnant women in Kenya

Okoth, Fredrick; Mbuthia, J.; Gatheru, Zipporah; Murila, Florence; Kanyingi, F; Mugo, F.; Esamai, Fabian; Alavi, Zarrin; Otieno, Juliana A.; Kiambati, H; Wanjuki, N.

doi:10.4314/eamj.v83i09.46771

Cited by 41 publications

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“…The results of the overall and regional HBs Ag prevalence and differences between regions were presented and discussed in the first paper of this study [6]. Data for the associated factors was available for 2196 who consented and completed the study, 45 women did not complete the study.…”

Section: Resultsmentioning

confidence: 99%

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Factors Associated with Hepatitis B Surface Antigen Seroprevalence amongst Pregnant Women in Kenya

Gatheru¹,

Murila²,

Mbuthia³

et al. 2018

OJOG

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Background: Knowledge of factors associated with seroprevalence of Hepatitis B in pregnancy is important in informing policies towards prevention of vertical transmission of Hepatitis B Virus (HBV) infection, since in-utero and perinatal infection lead to chronic carrier state with severe long-term sequela. In addition, adequate and timely immunization plays a major role in the prevention of transmission. Objective: To determine the factors associated with HBs Ag seroprevalence in pregnant women from various geographical regions in Kenya. Methods and Subjects: This was a cross-sectional survey amongst all pregnant women attending antenatal clinics in Kenyatta National Hospital and 8 other hospitals from different regions of Kenya in their third trimester of pregnancy among June 2001 to June 2002. For each pregnant woman, age, history of intravenous drug use, sexually transmitted disease (STD), liver diseases, alcohol intake, blood transfusion (BT) and presence of traditional scarification were documented. HBs Ag serology was assayed at the Kenya Medical Research Institute (KEMRI) laboratory. Results: A total of 2241 pregnant women were enrolled in the study, 2196 consented, of whom 205 (9.3%) tested positive for HBs Ag. A significant association was found between HBs Ag seroprevalence and traditional scarification (p = 0.029), history of blood transfusion (p = 0.0024) and alcohol intake (p = 0.05). There was no significant association between Hbs Ag seroprevalence and sexually transmitted disease (p = 0.64). It was not possible to evaluate the association of HBs Ag seroprevalence with history of hospitalization for any liver disease including Hepatitis A, B or C, history of intravenous drug use or contact with sex partHow to cite this paper: Gatheru, Z., Murila, F., Mbuthia, J., Okoth, F., Kanyingi, F., Mugo, F., Esamai, F., Alavi, Z., Otieno, J., Kiambati, H. ners previously hospitalised for any liver disease including Hepatitis A, B or C as the numbers with these attributes were small. Conclusions: We found 9.3% of pregnant women were HBs Ag positive, significantly higher than previously observed. The high seropositivity was associated with traditional scarification, history of blood transfusion and alcohol intake. Proper screening of blood transfusion products, immunization and control of scarification and alcohol use should be considered by health policy experts.

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Section: Resultsmentioning

confidence: 99%

“…Kenya is comprised of various ethnic groups with different cultures and traditions that are practiced and carry a risk of enhancing HBV transmission [5] [6]. In this study, we aimed at highlighting possible factors responsible for horizontal transmission of HBV infection.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Hepatitis B Surface Antigen Seroprevalence amongst Pregnant Women in Kenya

Gatheru¹,

Murila²,

Mbuthia³

et al. 2018

OJOG

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“…The epidemiological data of the general population in southern Sudan revealed prevalence of 26% for HBsAg [4], indicating in general that Sudan is endemic area for HBsAg. Worldwide sero-epidemiological studies for HBV infection in pregnant women varies considerably; some countries, e.g., Italy revealed a prevalence of only 1% [5], and that was considered relatively low when compared to a much highly endemic areas like Kenya and Egypt when the prevalence was estimated to be 9.3% and 15.3% respectively [6,7]. Except for Oman which has the highest prevalence of 7.1% for HBs Ag sero-positivity, other gulf countries seem to have a low prevalence, as it is 2.4% in Saudi Arabia, 1% in Qatar and 1.5% in UAE [8,9].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B Infection among Pregnant Women at Khartoum Teaching Hospital, Sudan

Abuelgasim¹,

Baraka²

2015

UCMS

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Abstract:The aim of this study was to determine the prevalence of hepatitis B infection in pregnant women and to evaluate the risk factors of hepatitis B infection. The study was conducted during the period (March to June, 2010) in Khartoum state, Sudan. A total of 160 pregnant women who presented to the labor ward or antenatal clinic of Khartoum Teaching Hospital were enrolled. Socio-demographic characteristics were gathered, in addition to obstetric history through a structured questionnaire. Hepatitis B surface antigen was assayed using rapid test. The seropositivity among the studied population was 12 (7.5%) for HBsAg (Hepatitis B surface antigen). Some of the studied risk factors were found to be statistically significant in relation to hepatitis B virus infection among Sudanese pregnant women in Khartoum state. The study concluded that HBV infection among pregnant Sudanese women is of high endemicity in Khartoum state.

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“…Contrary, it was higher than the study conducted in India (0.9%) [26] and Tripoli, Libya (1.5%) [27]. However, other several studies have been reported higher prevalence of HBV among pregnant women, for example 9.3% in Kenya [28] [35]. Geographical differences have been identified as the main reason for the variation of seroprevalence rates of HBV infection among pregnant women in different countries [36].…”

Section: Discussionmentioning

confidence: 65%

Factors Associated with Hepatitis B Surface Antigen Seropositivity among Pregnant Women in Kigali, Rwanda: A Cross Sectional Study

Nyamusi¹,

M’Imunya²,

Muvunyi³

et al. 2017

J Comm Pub Health Nurs

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Seroprevalence of Hepatitis B markers in pregnant women in Kenya

Cited by 41 publications

References 0 publications

Factors Associated with Hepatitis B Surface Antigen Seroprevalence amongst Pregnant Women in Kenya

Factors Associated with Hepatitis B Surface Antigen Seroprevalence amongst Pregnant Women in Kenya

Prevalence of Hepatitis B Infection among Pregnant Women at Khartoum Teaching Hospital, Sudan

Factors Associated with Hepatitis B Surface Antigen Seropositivity among Pregnant Women in Kigali, Rwanda: A Cross Sectional Study

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