Seroprevalence of antibodies to Venezuelan equine encephalitis complex (subtypes IAB and VI) in humans from General Belgrano Island, Formosa, Argentina

Cámara, Alicia; Díaz, G; Vega, Víctor Rodríguez; Basualdo, María; Contigiani, Marta Silvia

doi:10.1590/s0036-46652003000400005

Cited by 11 publications

(9 citation statements)

References 11 publications

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“…In addition to providing opportunities for cross-reactivity, there is strong epidemiologic evidence linking many of these alphaviruses with human illness. [9][10][11][12][13][14][15][16][17][18][19][20] In addition, laboratory and epidemiologic observations have shown some cross-protection among alphaviruses, [21][22][23][24] although other studies contradict those find-ings. 25,26 In an attempt to resolve its role in alphaviral disease and epidemiology, we first assessed cross-protection in mice and hamsters first infected with VEEV and MAYV, the most prevalent alphaviruses infecting humans in the Amazon region of Peru, and challenged with EEEV.…”

Section: Introductionmentioning

confidence: 99%

Endemic Eastern Equine Encephalitis in the Amazon Region of Peru

Aguilar¹,

Robich²,

Turell³

et al. 2007

The American Journal of Tropical Medicine and Hygiene

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Eastern equine encephalitis virus (EEEV) causes severe neurologic disease in North America, but only two fatal human cases have been documented in South America. To test the hypothesis that alphavirus heterologous antibodies cross-protect, animals were vaccinated against other alphaviruses and challenged up to 3 months later with EEEV. Short-lived cross-protection was detected, even in the absence of cross-neutralizing antibodies. To assess exposure to EEEV in Peru, sera from acutely ill and healthy persons were tested for EEEV and other alphavirus antibodies, as well as for virus isolation. No EEEV was isolated from patients living in an EEEV-enzootic area, and only 2% of individuals with febrile illness had EEEV-reactive IgM. Only 3% of healthy persons from the enzootic region had EEEV-neutralizing antibodies. Our results suggest that humans are exposed but do not develop apparent infection with EEEV because of poor infectivity and/or avirulence of South American strains.

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Section: Introductionmentioning

confidence: 99%

Endemic Eastern Equine Encephalitis in the Amazon Region of Peru

Aguilar¹,

Robich²,

Turell³

et al. 2007

The American Journal of Tropical Medicine and Hygiene

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“…For arboviruses, PRNT is the gold standard technique due to its high sensitivity and specificity. In Argentina, there is serological evidence of the presence of VEEV since 1950's decade in humans and rodents [24], [21], [11]. Our studies detected current VEEV activity in the North part of the country.…”

Section: Discussionmentioning

confidence: 50%

“…This should be considered cautiously, since there is no evidence of epidemic/epizootic viral activity in our region, but the circulation of an enzootic variety of other subtype I might exist. This hypothesis was first proposed by Monath in 1985, and is supported by previous detections of antibodies against VEEV IAB in animals during the 80's [21] and in humans in 1991 [11], although no isolations of members of this subtype have been reported up to date. This leaves an open door to suspect that these antibodies previously detected could correspond to antibodies against PIXV captured by TC83 strain in the PRNT.…”

Section: Discussionmentioning

confidence: 59%

“…In 1989, Contigiani et al reported an outbreak of acute febrile illness in humans from General Belgrano Island (Formosa province) associated to RNV, with symptoms indistinguishable from dengue [10]. Subsequent serological studies carried out in the same area showed the presence of human antibodies not only against RNV, but also against subtype IAB (TC83 vaccine strain) [11]. Recent investigations have reported the molecular detection of RNV and Pixuna Virus (VEEV subtype IV; PIXV) in Chaco and Tucumán provinces [7], [8], demonstrating that more than one VEEV is currently active in Argentina.…”

Section: Introductionmentioning

confidence: 99%

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Venezuelan Equine Encephalitis Viruses (VEEV) in Argentina: Serological Evidence of Human Infection

et al. 2013

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Venezuelan equine encephalitis viruses (VEEV) are responsible for human diseases in the Americas, producing severe or mild illness with symptoms indistinguishable from dengue and other arboviral diseases. For this reason, many cases remain without certain diagnosis. Seroprevalence studies for VEEV subtypes IAB, ID, IF (Mosso das Pedras virus; MDPV), IV (Pixuna virus; PIXV) and VI (Rio Negro virus; RNV) were conducted in persons from Northern provinces of Argentina: Salta, Chaco and Corrientes, using plaque reduction neutralization test (PRNT). RNV was detected in all studied provinces. Chaco presented the highest prevalence of this virus (14.1%). Antibodies against VEEV IAB and -for the first time- against MDPV and PIXV were also detected in Chaco province. In Corrientes, seroprevalence against RNV was 1.3% in the pediatric population, indicating recent infections. In Salta, this was the first investigation of VEEV members, and antibodies against RNV and PIXV were detected. These results provide evidence of circulation of many VEE viruses in Northern Argentina, showing that surveillance of these infectious agents should be intensified.

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“…1999) (Figure 1). Serological studies indicate the presence of human antibodies against more than one enzootic subtype (I and VI) in subtropical regions of Argentina (Cámara et al. 2003).…”

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confidence: 99%

Cocirculation of Rio Negro Virus (RNV) and Pixuna Virus (PIXV) in Tucumán province, Argentina

Pisano

Dantur

Ré

et al. 2010

Tropical Med Int Health

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Summary Venezuelan equine encephalitis complex includes viruses considered emerging pathogens for humans and animals in the Americas. Two members of this complex have been detected previously in Argentina: Rio Negro Virus (RNV), detected in mosquitoes from Chaco province and rodents from Formosa province, and Pixuna Virus (PIXV), detected in mosquitoes from Chaco province. To carry out surveillance studies in other parts of the country, detection of a 195‐bp fragment of alphaviruses by RT‐nested PCR was performed in mosquito samples from San Miguel de Tucumán city. Four pools resulted positive and three were sequenced. Two amplicons grouped with RNV and one with PIXV. This is the first report of viral activity of members of the Venezuelan equine encephalitis complex in north‐eastern Argentina.

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Seroprevalence of antibodies to Venezuelan equine encephalitis complex (subtypes IAB and VI) in humans from General Belgrano Island, Formosa, Argentina

Cited by 11 publications

References 11 publications

Endemic Eastern Equine Encephalitis in the Amazon Region of Peru

Endemic Eastern Equine Encephalitis in the Amazon Region of Peru

Venezuelan Equine Encephalitis Viruses (VEEV) in Argentina: Serological Evidence of Human Infection

Cocirculation of Rio Negro Virus (RNV) and Pixuna Virus (PIXV) in Tucumán province, Argentina

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