Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan

Chan, Yu Jiun; Lee, Chia Ling; Hwang, Shinn Jang; Fung, Chang Phone; Wang, Fu Der; Yen, David Hung Tsang; Tsai, Chao-Ming; Chen, Yi Ming Arthur; Lee, Shou Dong

doi:10.1016/s1726-4901(10)70003-4

Cited by 44 publications

(42 citation statements)

References 17 publications

(18 reference statements)

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“…Information about the prevalence of H1N1 infection in Taiwan general population was also limited. 5,6 To date, only two adult patients and seven children have been reported in the literature as having acute fulminant myocarditis because of H1N1 infection. 7e9 Although influenza-associated myocarditis carries a high mortality rate in acute stage, the survivors have excellent outcome when compared to individuals who contract other types of acute viral myocarditis.…”

Section: Discussionmentioning

confidence: 99%

Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Liao

Hsieh²,

Chang³

et al. 2011

Journal of the Chinese Medical Association

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The worldwide outbreak of pandemic influenza A (H1N1 influenza) infection in 2009 caused numerous hospitalizations and deaths resulting from severe complications such as pneumonia, sepsis, and acute respiratory distress syndrome. Fulminant myocarditis caused by H1N1 infection has been reported in children but rarely in adults. We present an adult who contracted H1N1 infection followed by fulminant myocarditis. Early implementation of extra-corporeal membrane oxygenation support in conjunction with a specific anti-influenza viral medication (Oseltamivir) led to the patient's complete recovery from cardiogenic shock in 2 weeks.

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Section: Discussionmentioning

confidence: 99%

Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Liao

Hsieh²,

Chang³

et al. 2011

Journal of the Chinese Medical Association

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“…These workers were provided with personal protective equipment (surgical scrubs, disposable surgical gowns, masks, and gloves) to minimise the risk of infection, and they practised good infection control; however, they are assumed to have had greater exposure to influenza than those who did not work at the community-based assessment centres. Higher rates of seroconversion have been reported previously among frontline hospital healthcare workers compared to hospital staff working in non-front-line positions, 7 but it is not known whether primary care staff may also have been exposed to differential levels of risk.…”

Section: Introductionmentioning

confidence: 87%

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

Hudson¹,

Toop²,

Mangin³

et al. 2013

Br J Gen Pract

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“…In this study the lower seroprevalence in HCWs compared to household contacts could be due to the HCW reduced time of exposure, and to the use of personal protective equipment [21]. In a medical centre in Taiwan, 20% of HCWs had seroprotective titres compared to 3% of the control group (p < 0.001) [22]. HCW will continue to be at the top of the priority list for vaccination, as it seems that, based on seroprevalence and seroprotection data, a substantial proportion of HCWs remain susceptible even after the first waves of the pandemic.…”

Section: Discussionmentioning

confidence: 67%

Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico

Novales

Arriaga-Pizano

Herrera-Castillo

et al. 2015

J Infect Dev Ctries

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Introduction: On April 2009, the Mexican Ministry of Health received notification of cases of severe pneumonia mostly affecting young healthy people; this was the beginning of the first influenza pandemic of the 21st century. The nature of the immune response to the influenza A(H1N1)2009 pandemic strain in Mexico at the beginning of the pandemic outbreak has not been completely defined. We describe the serological response to the 2009 pandemic influenza virus in paediatric patients with influenza-like illness, their household contacts (HHCs), and exposed health-care workers (HCWs) at the beginning of the pandemic outbreak in Mexico City. Methodology: thirty pre-epidemic and 129 epidemic samples were collected and serum antibodies were measured against A(H1N1)2009 pandemic virus and two non-pandemic swine influenza viruses by an haemagglutination inhibition assay . Results: 91% (29/32) of the convalescence samples from confirmed patients had an antibody titre ≥ 10 (GMT 25), 63% (41/65) of the HHCs (GMT 12), 41% of HCWs (GMT 6) and 13% (4/30) of pre-epidemic samples (GMT 6) for the pandemic influenza virus. Of the 32 confirmed cases, 60% had an antibody titre ≥ 40 for the pandemic strain, 53% for the A/swine/Iowa(H1N1) virus (GMT 62) and 43% for the A/swine/Texas(H3N2) virus (GMT 66). Conclusion: The antibody response to 2009 pandemic influenza virus was widespread in convalescence samples from patients with confirmed pandemic influenza infection but the GMT was below the protective titre. There was no evidence that antibodies to the swine influenza viruses had cross-protective effect against the 2009 pandemic influenza virus.

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Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan

Cited by 44 publications

References 17 publications

Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Fulminant myocarditis in an adult with 2009 pandemic influenza A (H1N1 influenza) infection

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico

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