Serological examination of fattening pigs reveals associations between Ascaris suum, lung pathogens and technical performance parameters

Vlaminck, Johnny; Düsseldorf, Simon; Heres, L.; Geldhof, Peter

doi:10.1016/j.vetpar.2015.04.012

Cited by 36 publications

(33 citation statements)

References 33 publications

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“…Recent studies have proven the usefulness of serological assays for Ascaris suum diagnosis in pigs. Serum antibody responses against an antigen from adult worms (A. suum haemoglobin (AsHb) and the total extract of A. suum lung stage L3 larvae (AsLungL3) showed higher sensitivity than copromicroscopy to identify exposure to both experimental and natural A. suum infections [13,14] and provided more accurate assessments of disease burden [14][15][16][17][18]. It is however difficult, if not impossible, to obtain similar high-quality data from studies in human populations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of copromicroscopy and serology to measure the exposure to Ascaris infections across age groups and to assess the impact of 3 years of biannual mass drug administration in Jimma Town, Ethiopia

et al. 2020

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Background The scientific community has recently summarized the desired characteristics for diagnostic tools across the different phases of a soil-transmitted helminth (STH) mass drug administration (MDA) program. Although serology meets some of the desired criteria, there is a scarcity of data on baseline serological profiles in human populations, both prior to and during MDA programs. Methods In this study, we compared the copromicroscopic and the serological infection profiles in 600 school-aged children (SAC) and 600 adults at the advent of the MDA program in Jimma Town, Ethiopia. The serological profiles were examined by two ELISAs that measure IgG4 responses to the Ascaris suum haemoglobin antigen (AsHb) and a somatic extract of lung stage larvae (AsLungL3). Three years into the MDA program, we sampled another group of 600 SAC from the same schools to assess the reduction in prevalence and intensity of Ascaris infections measured by copromicroscopy and serology.

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Section: Introductionmentioning

confidence: 99%

Evaluation of copromicroscopy and serology to measure the exposure to Ascaris infections across age groups and to assess the impact of 3 years of biannual mass drug administration in Jimma Town, Ethiopia

et al. 2020

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“…We then tested the anthelmintic activity of isolated PA fractions against Ascaris suum, which is a highly prevalent gastrointestinal parasite of pigs worldwide, and has been reported to significantly reduce growth and performance (Hale et al, 1985;Vlaminck et al, 2015). Table 1 The composition of proanthocyanidins (PA) in whole shea meal (in situ PA), extract (extractable PA) and residue (unextractable PA) in terms of PA content, mean degree of polymerisation (mDP), molar percentages (%) of procyanidins (PC) and prodelphinidins (PD), of cis-and trans-flavan-3-ols and of galloylated flavan-3-ols (Xg) (SD in parentheses; n = 3).…”

Section: Introductionmentioning

confidence: 99%

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

et al. 2016

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Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography-mass spectrometry. These PA were galloylated (≈40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode.

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“…It has been reported that the occurrence of a subclinical form of Ascaris suum infection in fattening pigs leads to a decrease in daily weight gain of about 80 g and increase in feed consumption of 230 g on 1 kg of body weight gain (Knecht et al, 2012), resulting in later date of slaughter weight attainment of 10-15 days (Knecht et al, 2011). Considering that milk spots can appear as early as 3 days post-infection, start to resolve after about 2-3 weeks (Vlaminck et al, 2015), and disappear in the course of 3-6 weeks post-infection (Boes et al, 2010), it can be assumed that the reduction in slaughter weight occurred during the last few weeks of fattening. In addition, pigs showing liver milk spots had a significantly higher fat thickness, but had a lower meatiness than pigs without pathological lesions in the livers (P<0.05, Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Although a number of studies have previously reported that ascariasis results in significant economic losses to the pig industry, the occurrence of this helminth infection both under conditions of intensive and extensive pig breeding remains high (Vlaminck et al, 2015). This can be ascribed to the facts that, in most cases, ascariasis occur in a subclinical form and that exposure of animals to this parasite cannot be unambiguously diagnosed (Vlaminck et al, 2015). Ascariasis can be identified in slaughtered pigs through the presence of milk spots -whitish healing foci which result from Ascaris suum larval migration through the liver stroma (Sanchez-Vazquez et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Blood parameters, carcass and meat quality of slaughter pigs with and without liver milk spots

Čobanović¹,

Василев²,

Dimitrijević³

et al. 2017

BIOTEC ANIM HUSB

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The aim of this study was to determine the influence of liver milk spots on hematological, carcass and meat quality parameters in slaughter pigs. A total of 120 pigs with a live weight of approximately 115 kg and six months old were examined. Any signs of liver milk spots were recorded as present or absent according to Welfare Quality® protocol (2009). A complete blood picture was investigated. The following carcass quality parameters were measured: live, hot and cold carcass weights, dressing percentage, backfat thickness and meatiness. pH and temperature measurements were performed 45 minutes postmortem. Pork quality classes (PSE-pale, soft and exudative, normal, DFD-dark, firm and dry meat) were determined according to Adzitey and Nurul (2011) using pH 45 value. Pigs with liver milk spots had significantly higher middle-sized cell count (monocytes, eosinophils, and basophils) and neutrophils count, but significantly lower red blood cell count, hemoglobin concentration, hematocrit and MCV than unaffected pigs. The same group of pigs had significantly lower live weight, hot carcass weight, cold carcass weight, dressing percentage and meatiness compared to the pigs free of milk spot lesions. Pigs showing liver milk spots had significantly higher pH 45 value and incidence of DFD meat than pigs without pathological lesions in the livers. In conclusion, assessment of liver milk spots at slaughter line has potential to serve not only as an indirect measure of pig health and welfare, but also for the carcass and pork quality.

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Serological examination of fattening pigs reveals associations between Ascaris suum, lung pathogens and technical performance parameters

Cited by 36 publications

References 33 publications

Evaluation of copromicroscopy and serology to measure the exposure to Ascaris infections across age groups and to assess the impact of 3 years of biannual mass drug administration in Jimma Town, Ethiopia

Evaluation of copromicroscopy and serology to measure the exposure to Ascaris infections across age groups and to assess the impact of 3 years of biannual mass drug administration in Jimma Town, Ethiopia

Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum

Blood parameters, carcass and meat quality of slaughter pigs with and without liver milk spots

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